Characterization of ACE Inhibitors and AT
ACE inhibitor
AT1 receptor antagonist
SARS-CoV-2
cell barrier integrity
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
10 Aug 2021
10 Aug 2021
Historique:
received:
06
07
2021
revised:
29
07
2021
accepted:
06
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Blood-pressure-lowering drugs are proposed to foster SARS-CoV-2 infection by pharmacological upregulation of angiotensin-converting enzyme 2 (ACE2), the binding partner of the virus spike (S) protein, located on the surface of the host cells. Conversely, it is postulated that angiotensin-renin system antagonists may prevent lung damage caused by SARS-CoV-2 infection, by reducing angiotensin II levels, which can induce permeability of lung endothelial barrier via its interaction with the AT We have investigated the influence of the ACE inhibitors (lisinopril, captopril) and the AT The drugs revealed no effect on ACE2 mRNA and protein expression. ACE inhibitors and AT ACE inhibitors and AT
Identifiants
pubmed: 34440554
pii: life11080810
doi: 10.3390/life11080810
pmc: PMC8399150
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : project CARS; funding code 01KI20179
Organisme : Landesoffensive zur Entwicklung wissenschaftlich-ökonomischer Exzellenz
ID : DRUID, TBG, TMP
Organisme : Fraunhofer Internal Program
ID : Grant No. Anti-Corona 840260 (DRECOR) and CIMD
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