Heat Shock Proteins: Connectors between Heart and Kidney.
cardiac diseases
cardiorenal syndrome
heat shock proteins
immune system
renal diseases
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
30 07 2021
30 07 2021
Historique:
received:
29
06
2021
revised:
26
07
2021
accepted:
27
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Over the development of eukaryotic cells, intrinsic mechanisms have been developed in order to provide the ability to defend against aggressive agents. In this sense, a group of proteins plays a crucial role in controlling the production of several proteins, guaranteeing cell survival. The heat shock proteins (HSPs), are a family of proteins that have been linked to different cellular functions, being activated under conditions of cellular stress, not only imposed by thermal variation but also toxins, radiation, infectious agents, hypoxia, etc. Regarding pathological situations as seen in cardiorenal syndrome (CRS), HSPs have been shown to be important mediators involved in the control of gene transcription and intracellular signaling, in addition to be an important connector with the immune system. CRS is classified as acute or chronic and according to the first organ to suffer the injury, which can be the heart (CRS type 1 and type 2), kidneys (CRS type 3 and 4) or both (CRS type 5). In all types of CRS, the immune system, redox balance, mitochondrial dysfunction, and tissue remodeling have been the subject of numerous studies in the literature in order to elucidate mechanisms and propose new therapeutic strategies. In this sense, HSPs have been targeted by researchers as important connectors between kidney and heart. Thus, the present review has a focus to present the state of the art regarding the role of HSPs in the pathophysiology of cardiac and renal alterations, as well their role in the kidney-heart axis.
Identifiants
pubmed: 34440708
pii: cells10081939
doi: 10.3390/cells10081939
pmc: PMC8391307
pii:
doi:
Substances chimiques
Heat-Shock Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2008/10175-4
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2015/19107-5
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2018/03089-6
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2019/11077-0
Organisme : Universidade Federal do Paraná
ID : 02/2019
Organisme : Universidade Federal do Paraná
ID : 2020
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 001
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 310681/2018-9
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : 232734
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