A Comprehensive Review of the Genomics of Multiple Myeloma: Evolutionary Trajectories, Gene Expression Profiling, and Emerging Therapeutics.
Ataxia Telangiectasia Mutated Proteins
/ genetics
Gene Expression
Humans
Monoclonal Gammopathy of Undetermined Significance
/ genetics
Multiple Myeloma
/ drug therapy
Poly(ADP-ribose) Polymerase Inhibitors
/ therapeutic use
Polymorphism, Single Nucleotide
Prognosis
Tumor Suppressor Protein p53
/ genetics
ras Proteins
/ genetics
genomics
multiple myeloma
plasma cell dyscrasia
prognosis
risk stratification
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 08 2021
02 08 2021
Historique:
received:
28
06
2021
revised:
21
07
2021
accepted:
30
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
12
11
2021
Statut:
epublish
Résumé
Multiple myeloma (MM) is a blood cancer characterized by the accumulation of malignant monoclonal plasma cells in the bone marrow. It develops through a series of premalignant plasma cell dyscrasia stages, most notable of which is the Monoclonal Gammopathy of Undetermined Significance (MGUS). Significant advances have been achieved in uncovering the genomic aberrancies underlying the pathogenesis of MGUS-MM. In this review, we discuss in-depth the genomic evolution of MM and focus on the prognostic implications of the accompanied molecular and cytogenetic aberrations. We also dive into the latest investigatory techniques used for the diagnoses and risk stratification of MM patients.
Identifiants
pubmed: 34440730
pii: cells10081961
doi: 10.3390/cells10081961
pmc: PMC8391934
pii:
doi:
Substances chimiques
Poly(ADP-ribose) Polymerase Inhibitors
0
Tumor Suppressor Protein p53
0
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
ras Proteins
EC 3.6.5.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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