Loosening ER-Mitochondria Coupling by the Expression of the Presenilin 2 Loop Domain.
Alzheimer’s disease
Ca2+ signaling
ER
MAM
Presenilin 2
mitochondria
organelle contacts
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
03 08 2021
03 08 2021
Historique:
received:
01
07
2021
revised:
27
07
2021
accepted:
29
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
18
11
2021
Statut:
epublish
Résumé
Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer's disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid peptide formation. In particular, its enrichment in endoplasmic reticulum (ER) membrane domains close to mitochondria (i.e., mitochondria-associated membranes, MAM) enables PS2 to modulate multiple processes taking place on these signaling hubs, such as Ca
Identifiants
pubmed: 34440738
pii: cells10081968
doi: 10.3390/cells10081968
pmc: PMC8394530
pii:
doi:
Substances chimiques
Presenilin-1
0
Presenilin-2
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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