Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1.

Adipocytes / metabolism Animals Carcinoembryonic Antigen / genetics Endothelial Cells / metabolism Endothelium, Vascular / metabolism Fats / metabolism Glucose / metabolism Inflammation Insulin / metabolism Insulin Resistance / genetics Liver / cytology Mice Mice, Knockout NF-kappa B / metabolism Nitric Oxide / metabolism Signal Transduction
carcinoembryonic antigen-related cell adhesion molecule-1 insulin clearance insulin resistance insulin transport normo-insulinemia

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
14 08 2021
Historique:
received: 26 07 2021
revised: 10 08 2021
accepted: 11 08 2021
entrez: 27 8 2021
pubmed: 28 8 2021
medline: 16 11 2021
Statut: epublish

Résumé

CEACAM1 regulates endothelial barrier integrity. Because insulin signaling in extrahepatic target tissues is regulated by insulin transport through the endothelium, we aimed at investigating the metabolic role of endothelial CEACAM1. To this end, we generated endothelial cell-specific

Identifiants

DOI: 10.3390/cells10082093 PMID: 34440862 PMC: PMC8394790
pubmed: 34440862
pii: cells10082093
doi: 10.3390/cells10082093
pmc: PMC8394790
pii:
doi:

Substances chimiques

Carcinoembryonic Antigen 0
Ceacam1 protein, mouse 0
Fats 0
Insulin 0
NF-kappa B 0
Nitric Oxide 31C4KY9ESH
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK083850
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL112248
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK054254
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124126
Pays : United States

Références

Circ Res. 2008 May 23;102(10):1192-201
pubmed: 18420943
J Biol Chem. 2001 Jun 29;276(26):24331-40
pubmed: 11306560
Thromb Haemost. 2014 Dec;112(6):1088-102
pubmed: 25078148
J Clin Invest. 2006 Jun;116(6):1596-605
pubmed: 16680193
Nat Genet. 2002 Mar;30(3):270-6
pubmed: 11850617
Oncogene. 2011 Oct 13;30(41):4275-88
pubmed: 21532628
Cell Metab. 2021 Apr 6;33(4):758-780
pubmed: 33826918
Diabetologia. 2017 Dec;60(12):2463-2474
pubmed: 28913658
Diabetes. 2016 Jun;65(6):1452-61
pubmed: 27222389
J Cell Biochem. 2008 Jun 1;104(3):733-44
pubmed: 18253935
Physiology (Bethesda). 2012 Aug;27(4):237-47
pubmed: 22875454
J Biol Chem. 2002 Jan 11;277(2):1076-84
pubmed: 11694516
J Anat. 2002 Jun;200(6):561-74
pubmed: 12162724
Nat Protoc. 2015 Feb;10(2):305-15
pubmed: 25612230
J Cell Sci. 2010 Dec 15;123(Pt 24):4221-30
pubmed: 21081647
Mol Cancer. 2014 Mar 21;13:64
pubmed: 24650050
J Biol Chem. 2016 Nov 11;291(46):23915-23924
pubmed: 27662905
J Clin Invest. 2017 Jan 3;127(1):1-4
pubmed: 28045402
Front Endocrinol (Lausanne). 2015 Aug 03;6:116
pubmed: 26284027
PLoS One. 2011 Jan 14;6(1):e14525
pubmed: 21264293
Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E34-46
pubmed: 24824652
Hepatol Commun. 2020 Sep 03;4(11):1591-1609
pubmed: 33163831
Diabetes. 2013 Dec;62(12):4030-42
pubmed: 23863813
Traffic. 2019 Jun;20(6):390-403
pubmed: 30950163
J Biol Chem. 1995 Sep 29;270(39):23077-83
pubmed: 7559449
Diabetes. 2015 Aug;64(8):2780-90
pubmed: 25972571
Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E134-44
pubmed: 20959538
Histochem Cell Biol. 2016 Dec;146(6):657-671
pubmed: 27695943
Diabetes. 2008 Sep;57(9):2296-303
pubmed: 18544705
Mol Metab. 2018 Mar;9:98-113
pubmed: 29396368
J Clin Invest. 2003 May;111(9):1373-80
pubmed: 12727929
Trends Endocrinol Metab. 2002 Aug;13(6):240-5
pubmed: 12128284
J Cell Mol Med. 2007 Jan-Feb;11(1):139-47
pubmed: 17367508
Atherosclerosis. 2021 Jul;329:1-8
pubmed: 34130222
FASEB J. 2018 Oct;32(10):5612-5625
pubmed: 29746166
Semin Immunol. 2019 Apr;42:101296
pubmed: 31604530
Biochemistry. 1995 Jul 25;34(29):9341-9
pubmed: 7626603
J Clin Endocrinol Metab. 2004 Sep;89(9):4649-55
pubmed: 15356076
J Biol Chem. 1993 Jan 15;268(2):1201-6
pubmed: 8380406
Oncotarget. 2016 Oct 11;7(41):66468-66479
pubmed: 27634893
Metabolism. 2019 Apr;93:33-43
pubmed: 30664851
Physiology (Bethesda). 2019 May 1;34(3):198-215
pubmed: 30968756
Mol Cell Biol. 2000 Jun;20(11):3896-905
pubmed: 10805733
Cancer Res. 2003 Jun 15;63(12):3145-53
pubmed: 12810642
Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E519-29
pubmed: 23800882
FASEB J. 2019 Nov;33(11):11993-12007
pubmed: 31393790
Mol Biol Cell. 2015 Feb 15;26(4):740-50
pubmed: 25540431

Auteurs

Harrison T Muturi (HT)

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.

Saja S Khuder (SS)

Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606, USA.

Hilda E Ghadieh (HE)

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.

Emily L Esakov (EL)

Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606, USA.
Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH 43606, USA.
ORCID: 0000-0002-5049-2096

Hyelim Noh (H)

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
ORCID: 0000-0001-9284-0557

Heejoon Kang (H)

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Department of Breast-Endocrine Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Korea.

Marcia F McInerney (MF)

Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606, USA.
Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH 43606, USA.
ORCID: 0000-0001-9348-2480

Jason K Kim (JK)

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Division of Endocrinology, Metabolism and Diabetes, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abraham D Lee (AD)

Department of Rehabilitation Sciences, Judith Herb College of Education, Human Science and Human Service, The University of Toledo, Toledo, OH 43606, USA.

Sonia M Najjar (SM)

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606, USA.
Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Eucaryotes › Animaux › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène carcinoembryonnaire › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Lipides › Matières grasses › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Système digestif › Foie › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Insulin Sensitivity Is Retained in Mice with...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Insulin Sensitivity Is Retained in Mice with...
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