The Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review with a Pooled Analysis of Only Surgery versus Combined Protocols.

Bisphosphonate-Associated Osteonecrosis of the Jaw / surgery Bone Density Conservation Agents / adverse effects Diphosphonates Humans
ONJ osteonecrosis staging surgery therapy treatment

Journal

International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455

Informations de publication

Date de publication:
10 08 2021
Historique:
received: 29 06 2021
revised: 30 07 2021
accepted: 03 08 2021
entrez: 27 8 2021
pubmed: 28 8 2021
medline: 4 9 2021
Statut: epublish

Résumé

Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents, and it is also a potentially painful and debilitating condition. To date, no specific studies have prospectively evaluated the efficacy of its treatment and no robust standard of care has been established. Therefore, a systematic review (2007-2020) with a pooled analysis was performed in order to compare MRONJ surgical techniques (conservative or aggressive) versus combined surgical procedures (surgery plus a non-invasive procedure), where 1137 patients were included in the pooled analysis. A statistically significant difference in the 6-month improvement rate, comparing combined conservative surgery versus only aggressive (91% versus 72%,

Identifiants

DOI: 10.3390/ijerph18168432 PMID: 34444181 PMC: PMC8392050
pubmed: 34444181
pii: ijerph18168432
doi: 10.3390/ijerph18168432
pmc: PMC8392050
pii:
doi:

Substances chimiques

Bone Density Conservation Agents 0
Diphosphonates 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Olga Di Fede (O)

Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, 90127 Palermo, Italy.
ORCID: 0000-0002-5562-7420

Federica Canepa (F)

Operative Unit of Dentistry and Stomatology, Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, 90146 Palermo, Italy.
ORCID: 0000-0001-9113-0182

Vera Panzarella (V)

Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, 90127 Palermo, Italy.
ORCID: 0000-0001-6339-6020

Rodolfo Mauceri (R)

Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, 90127 Palermo, Italy.
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, MSD 2090 Msida, Malta.
ORCID: 0000-0002-4008-6502

Carmine Del Gaizo (C)

Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, 90127 Palermo, Italy.

Alberto Bedogni (A)

Regional Center for Prevention, Diagnosis and Treatment of Medication and Radiation-Related Bone Diseases of the Head and Neck, University of Padova, 35128 Padova, Italy.

Vittorio Fusco (V)

Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.

Pietro Tozzo (P)

Operative Unit of Dentistry and Stomatology, Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, 90146 Palermo, Italy.

Giuseppe Pizzo (G)

Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, 90127 Palermo, Italy.
ORCID: 0000-0001-8119-4924

Giuseppina Campisi (G)

Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, 90127 Palermo, Italy.
ORCID: 0000-0002-9443-0495

Antonio Galvano (A)

Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, 90127 Palermo, Italy.
ORCID: 0000-0003-4365-5683

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Ostéonécrose › Ostéonécrose de la mâchoire associée aux biphosphonates › The Treatment of Medication-Related...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents de maintien de la densité osseuse › The Treatment of Medication-Related...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › The Treatment of Medication-Related...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Treatment of Medication-Related...