Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study.
biomarkers
dairy products
dietary biomarkers
food frequency questionnaire
iodine intake
iodine status
nutritional exposure
serum iodine
thyroglobulin
urinary iodine concentration
validation
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
23 Jul 2021
23 Jul 2021
Historique:
received:
02
07
2021
revised:
18
07
2021
accepted:
18
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
23
9
2021
Statut:
epublish
Résumé
The iodine status of the US population is considered adequate, but subpopulations remain at risk for iodine deficiency and a biomarker of individual iodine status has yet to be determined. The purpose of this study was to determine whether a 3 day titration diet, providing known quantities of iodized salt, is reflected in 24 h urinary iodine concentration (UIC), serum iodine, and thyroglobulin (Tg). A total of 10 participants (31.3 ± 4.0 years, 76.1 ± 6.3 kg) completed three, 3 day iodine titration diets (minimal iodine, US RDA, (United States Recommended Daily Allowance), and 3× RDA). The 24 h UIC, serum iodine, and Tg were measured following each diet. The 24 h UIC and an iodine-specific food frequency questionnaire (FFQ) were completed at baseline. UIC increased an average of 19.3 μg/L for every gram of iodized salt consumed and was different from minimal to RDA ( These results suggest that 24 h UIC and serum iodine may be reflective of individual iodine status and may serve as biomarkers of iodine status.
Sections du résumé
BACKGROUND
BACKGROUND
The iodine status of the US population is considered adequate, but subpopulations remain at risk for iodine deficiency and a biomarker of individual iodine status has yet to be determined. The purpose of this study was to determine whether a 3 day titration diet, providing known quantities of iodized salt, is reflected in 24 h urinary iodine concentration (UIC), serum iodine, and thyroglobulin (Tg).
METHODS
METHODS
A total of 10 participants (31.3 ± 4.0 years, 76.1 ± 6.3 kg) completed three, 3 day iodine titration diets (minimal iodine, US RDA, (United States Recommended Daily Allowance), and 3× RDA). The 24 h UIC, serum iodine, and Tg were measured following each diet. The 24 h UIC and an iodine-specific food frequency questionnaire (FFQ) were completed at baseline.
RESULTS
RESULTS
UIC increased an average of 19.3 μg/L for every gram of iodized salt consumed and was different from minimal to RDA (
CONCLUSION
CONCLUSIONS
These results suggest that 24 h UIC and serum iodine may be reflective of individual iodine status and may serve as biomarkers of iodine status.
Identifiants
pubmed: 34444680
pii: nu13082520
doi: 10.3390/nu13082520
pmc: PMC8398459
pii:
doi:
Substances chimiques
Biomarkers
0
Sodium Chloride, Dietary
0
iodized salt
0
Thyroglobulin
9010-34-8
Iodine
9679TC07X4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : T34 GM122835
Pays : United States
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