Macrophage Motility in Wound Healing Is Regulated by HIF-1α via S1P Signaling.
Animals
Cell Differentiation
/ genetics
Cell Movement
/ physiology
Cytokines
/ metabolism
Gene Expression
/ genetics
Gene Expression Regulation
/ genetics
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Inflammation
/ metabolism
Lysophospholipids
/ metabolism
Macrophage Activation
/ physiology
Macrophages
/ metabolism
Phosphatidylinositol 3-Kinases
/ metabolism
Signal Transduction
/ physiology
Sphingosine
/ analogs & derivatives
Wound Healing
/ physiology
HIF1
M1/M2 macrophage
S1P
wound healing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Aug 2021
20 Aug 2021
Historique:
received:
22
07
2021
revised:
14
08
2021
accepted:
18
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
30
9
2021
Statut:
epublish
Résumé
Accumulating evidence indicates that the molecular pathways mediating wound healing induce cell migration and localization of cytokines to sites of injury. Macrophages are immune cells that sense and actively respond to disturbances in tissue homeostasis by initiating, and subsequently resolving, inflammation. Hypoxic conditions generated at a wound site also strongly recruit macrophages and affect their function. Hypoxia inducible factor (HIF)-1α is a transcription factor that contributes to both glycolysis and the induction of inflammatory genes, while also being critical for macrophage activation. For the latter, HIF-1α regulates sphingosine 1-phosphate (S1P) to affect the migration, activation, differentiation, and polarization of macrophages. Recently, S1P and HIF-1α have received much attention, and various studies have been performed to investigate their roles in initiating and resolving inflammation via macrophages. It is hypothesized that the HIF-1α/S1P/S1P receptor axis is an important determinant of macrophage function under inflammatory conditions and during disease pathogenesis. Therefore, in this review, biological regulation of monocytes/macrophages in response to circulating HIF-1α is summarized, including signaling by S1P/S1P receptors, which have essential roles in wound healing.
Identifiants
pubmed: 34445695
pii: ijms22168992
doi: 10.3390/ijms22168992
pmc: PMC8396560
pii:
doi:
Substances chimiques
Cytokines
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Lysophospholipids
0
sphingosine 1-phosphate
26993-30-6
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18H03011
Références
J Oral Maxillofac Surg. 2005 Oct;63(10):1426-35
pubmed: 16182909
Clin Exp Immunol. 2011 May;164(2):248-55
pubmed: 21352201
Int J Mol Sci. 2016 Jun 03;17(6):
pubmed: 27271610
J Cell Physiol. 2018 Jan;234(1):550-560
pubmed: 30071127
Anesthesiology. 2018 Aug;129(2):311-320
pubmed: 29620575
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11715-20
pubmed: 9751731
Genes Dev. 2000 Jan 1;14(1):34-44
pubmed: 10640274
Front Immunol. 2014 Oct 07;5:491
pubmed: 25339958
J Biol Chem. 2002 Aug 30;277(35):31963-71
pubmed: 12070140
Biomol Ther (Seoul). 2019 Jul 1;27(4):373-380
pubmed: 30917625
Cancer Lett. 2008 Jul 18;266(1):12-20
pubmed: 18378391
Mol Cell Biol. 1996 Sep;16(9):4604-13
pubmed: 8756616
Nature. 1999 May 20;399(6733):271-5
pubmed: 10353251
Immunity. 2014 Oct 16;41(4):518-28
pubmed: 25367569
Sci Transl Med. 2018 Jul 25;10(451):
pubmed: 30045979
Cancer Res. 2000 Mar 15;60(6):1541-5
pubmed: 10749120
J Orthop Res. 2013 Nov;31(11):1845-50
pubmed: 23818033
J Immunol. 2006 Feb 1;176(3):1321-5
pubmed: 16424157
EMBO J. 2000 Aug 15;19(16):4298-309
pubmed: 10944113
EMBO J. 1999 Apr 1;18(7):1905-14
pubmed: 10202154
J Neuroinflammation. 2018 Oct 10;15(1):284
pubmed: 30305119
Annu Rev Biochem. 2013;82:637-62
pubmed: 23527695
Carcinogenesis. 2008 Apr;29(4):713-21
pubmed: 18258605
Traffic. 2007 Apr;8(4):311-30
pubmed: 17274798
Am J Pathol. 2011 Jan;178(1):19-25
pubmed: 21224038
Cell Death Differ. 2008 Apr;15(4):621-7
pubmed: 18259201
Am J Respir Crit Care Med. 2017 Dec 15;196(12):1559-1570
pubmed: 28850247
Front Immunol. 2020 Jun 26;11:1149
pubmed: 32695095
Wound Repair Regen. 2009 Sep-Oct;17(5):717-29
pubmed: 19769724
Eur Surg Res. 2012;49(1):35-43
pubmed: 22797712
Nat Immunol. 2013 Oct;14(10):986-95
pubmed: 24048120
Oral Dis. 2021 Mar 23;:
pubmed: 33759275
Nat Rev Immunol. 2018 Feb;18(2):85-86
pubmed: 29292392
Mol Immunol. 2013 Dec;56(4):347-53
pubmed: 23911389
Eur J Immunol. 2013 Jun;43(6):1667-75
pubmed: 23519784
J Immunol. 2005 Nov 15;175(10):6257-63
pubmed: 16272275
J Physiol. 2013 May 1;591(9):2245-57
pubmed: 23459758
Trends Pharmacol Sci. 2008 Nov;29(11):582-9
pubmed: 18814923
J Dent Res. 2009 Aug;88(8):757-61
pubmed: 19734465
Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12
pubmed: 23640484
J Biol Chem. 2000 Aug 18;275(33):25733-41
pubmed: 10823831
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4
pubmed: 7539918
J Leukoc Biol. 2007 Jul;82(1):16-32
pubmed: 17456803
Immunity. 2014 Jul 17;41(1):21-35
pubmed: 25035951
Biochem J. 2002 Feb 15;362(Pt 1):71-9
pubmed: 11829741
Front Physiol. 2018 May 01;9:419
pubmed: 29765329
IUBMB Life. 2008 Sep;60(9):591-7
pubmed: 18506846
Nature. 2009 Mar 26;458(7237):524-8
pubmed: 19204730
J Clin Invest. 2011 Mar;121(3):985-97
pubmed: 21317534
Nat Rev Immunol. 2011 Jun;11(6):403-15
pubmed: 21546914
Pharmacol Res. 2008 Aug;58(2):112-6
pubmed: 18723091
Nature. 2013 Apr 11;496(7444):238-42
pubmed: 23535595
Science. 2009 Jan 23;323(5913):524-7
pubmed: 19074308
FASEB J. 2008 Aug;22(8):2629-38
pubmed: 18362204
FASEB J. 2001 May;15(7):1312-4
pubmed: 11344124
Mol Cell Biol. 2007 May;27(9):3253-65
pubmed: 17325032
Mol Cells. 2010 May;29(5):435-42
pubmed: 20396958
Mol Cell. 2008 May 23;30(4):393-402
pubmed: 18498744
Microbiol Spectr. 2016 Jun;4(3):
pubmed: 27337444
Cell. 2007 Apr 6;129(1):111-22
pubmed: 17418790
Br J Pharmacol. 2009 Sep;158(1):41-9
pubmed: 19226283
Int J Mol Sci. 2020 Aug 05;21(16):
pubmed: 32764403
Nat Cell Biol. 2000 Jul;2(7):423-7
pubmed: 10878807
J Physiol. 2013 Apr 15;591(8):2027-42
pubmed: 23401619
J Dent Res. 2013 Aug;92(8):716-20
pubmed: 23694929
J Biol Chem. 2007 Sep 14;282(37):27171-27180
pubmed: 17631504
Science. 2007 Apr 13;316(5822):295-8
pubmed: 17363629
Front Immunol. 2019 Jul 19;10:1706
pubmed: 31379883
Mol Med Rep. 2016 Aug;14(2):1841-8
pubmed: 27357063
J Cell Mol Med. 2012 Sep;16(9):2049-59
pubmed: 22128786
Biochimie. 2010 May;92(5):538-44
pubmed: 20144679
Blood. 2009 Jul 23;114(4):844-59
pubmed: 19454749
J Immunol. 2013 May 1;190(9):4812-20
pubmed: 23547114
Biochim Biophys Acta. 2014 May;1841(5):759-65
pubmed: 23921254
Curr Biol. 2008 Dec 9;18(23):1882-8
pubmed: 19062281
Cell Signal. 2016 Sep;28(9):1349-63
pubmed: 27297359
PLoS One. 2012;7(8):e42964
pubmed: 22880134
Am J Physiol. 1996 Oct;271(4 Pt 1):C1172-80
pubmed: 8897823
J Periodontal Res. 2016 Feb;51(1):38-49
pubmed: 25900155
J Immunol. 2010 Apr 1;184(7):3964-77
pubmed: 20176743
Exp Mol Med. 2004 Feb 29;36(1):1-12
pubmed: 15031665
Biochem Biophys Res Commun. 1995 Nov 13;216(2):669-75
pubmed: 7488163
J Biol Chem. 2000 Aug 18;275(33):25130-8
pubmed: 10833514
Microsc Res Tech. 2002 Jun 15;57(6):421-31
pubmed: 12112425
Semin Cell Dev Biol. 2017 Jan;61:3-11
pubmed: 27521521
J Dent Res. 2005 Apr;84(4):309-14
pubmed: 15790734
Nat Rev Mol Cell Biol. 2008 Feb;9(2):139-50
pubmed: 18216770
Cancer Res. 2003 Dec 15;63(24):8700-7
pubmed: 14695184
J Biol Chem. 2003 Jul 18;278(29):26597-603
pubmed: 12734177
Ann Neurol. 2011 Jan;69(1):119-29
pubmed: 21280082
FASEB J. 2003 Feb;17(2):271-3
pubmed: 12490539
J Biol Chem. 2010 May 21;285(21):15848-57
pubmed: 20299461
Cell. 2007 Sep 21;130(6):1083-94
pubmed: 17825402
Jpn Dent Sci Rev. 2019 Nov;55(1):12-19
pubmed: 30733840
Brain Res. 2008 Mar 4;1197:152-8
pubmed: 18241842
J Dent Res. 1995 Dec;74(12):1826-32
pubmed: 8600176
Science. 2001 Apr 20;292(5516):464-8
pubmed: 11292862
Nature. 2021 Apr;592(7853):290-295
pubmed: 33658712
Cell Metab. 2006 Jul;4(1):13-24
pubmed: 16814729
Immunology. 2000 Sep;101(1):83-9
pubmed: 11012757
Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1873-9
pubmed: 19098317
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1782-90
pubmed: 27444197
Trends Immunol. 2004 Dec;25(12):677-86
pubmed: 15530839
Nat Rev Mol Cell Biol. 2003 May;4(5):397-407
pubmed: 12728273
Mitochondrion. 2010 Aug;10(5):516-27
pubmed: 20561910
J Clin Invest. 2016 Oct 3;126(10):3661-3671
pubmed: 27599290
Trends Mol Med. 2019 Jan;25(1):33-46
pubmed: 30442494
Kidney Int. 2008 Nov;74(10):1319-26
pubmed: 18769369
Biomaterials. 2013 Dec;34(38):9853-62
pubmed: 24064148
FASEB J. 2010 Dec;24(12):4701-10
pubmed: 20686109
Acta Pharmacol Sin. 2014 Dec;35(12):1537-45
pubmed: 25399649
Mol Cell Biol. 2005 Jun;25(12):4853-62
pubmed: 15923604
J Allergy Clin Immunol. 2015 Apr;135(4):1008-1018.e1
pubmed: 25512083
J Clin Invest. 2005 Jul;115(7):1806-15
pubmed: 16007254
J Lipid Res. 2014 Aug;55(8):1596-608
pubmed: 24459205
Oxid Med Cell Longev. 2016;2016:5679040
pubmed: 26798423
Nat Rev Immunol. 2011 Oct 14;11(11):723-37
pubmed: 21997792
J Neurochem. 2012 Dec;123(6):954-62
pubmed: 23043544
Nat Rev Immunol. 2019 Sep;19(9):539-549
pubmed: 31019284
J Biol Chem. 2000 Mar 10;275(10):6922-7
pubmed: 10702253
J Cell Sci. 2001 Nov;114(Pt 22):4051-61
pubmed: 11739637
J Biol Chem. 2003 Aug 15;278(33):31277-85
pubmed: 12764143
Cell Death Differ. 2008 Apr;15(4):660-6
pubmed: 18219320
Cancer Res. 2008 Oct 15;68(20):8635-42
pubmed: 18922940
Am J Pathol. 2015 Oct;185(10):2742-56
pubmed: 26272361
Immunol Rev. 2015 Mar;264(1):182-203
pubmed: 25703560
J Biol Chem. 2007 Jan 26;282(4):2125-9
pubmed: 17135245
Annu Rev Physiol. 2017 Feb 10;79:593-617
pubmed: 27959618
Science. 2009 Sep 4;325(5945):1254-7
pubmed: 19729656
Genes Dev. 2010 Mar 1;24(5):491-501
pubmed: 20194441
Kidney Int. 1997 Feb;51(2):553-5
pubmed: 9027737
Cell Metab. 2006 Mar;3(3):187-97
pubmed: 16517406
Arthritis Res Ther. 2009;11(1):215
pubmed: 19291263
J Mol Med (Berl). 2021 Feb;99(2):273-288
pubmed: 33388881
J Neurosci. 2005 Feb 9;25(6):1459-69
pubmed: 15703400
J Biol Chem. 1998 Mar 13;273(11):6417-23
pubmed: 9497373
J Pineal Res. 2011 Aug;51(1):87-93
pubmed: 21392092
Biochem Biophys Res Commun. 2017 Sep 2;490(4):1274-1281
pubmed: 28687489
Nat Immunol. 2010 Oct;11(10):936-44
pubmed: 20729857
Nat Commun. 2016 May 18;7:11635
pubmed: 27189088
J Exp Med. 2012 Jun 4;209(6):1167-81
pubmed: 22565823
FASEB J. 2005 Oct;19(12):1731-3
pubmed: 16046470
Biomed Res Int. 2017;2017:7584621
pubmed: 28367448
J Immunol. 2010 Feb 1;184(3):1475-83
pubmed: 20042570
Blood. 2004 Feb 1;103(3):1124-30
pubmed: 14525767
J Dermatol Sci. 2009 Dec;56(3):168-80
pubmed: 19854029
Circ Res. 2011 Feb 4;108(3):314-23
pubmed: 21164103
Adv Wound Care (New Rochelle). 2012 Feb;1(1):10-16
pubmed: 24527272
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Mol Med. 2012 Jul 18;18:753-61
pubmed: 22426954
Biochim Biophys Acta. 2015 Oct;1847(10):1254-66
pubmed: 26143176
J Dent Res. 2003 Aug;82(8):621-6
pubmed: 12885847
Biochem Biophys Res Commun. 2001 Sep 14;287(1):292-300
pubmed: 11549290
PLoS One. 2013 Dec 20;8(12):e82834
pubmed: 24376587
J Leukoc Biol. 2007 Aug;82(2):392-402
pubmed: 17505024
Mol Med Rep. 2020 Jul;22(1):310-316
pubmed: 32377729
J Biol Chem. 1997 Feb 28;272(9):5375-81
pubmed: 9038135
J Physiol. 2006 Jul 1;574(Pt 1):33-9
pubmed: 16709637
Eur J Immunol. 2020 Jun;50(6):839-845
pubmed: 32017036
Trends Cell Biol. 2002 May;12(5):236-42
pubmed: 12062172
PLoS One. 2016 May 25;11(5):e0156303
pubmed: 27224249
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10430-5
pubmed: 10973499
Diabetes. 2012 Dec;61(12):3148-55
pubmed: 22961081
Mediators Inflamm. 2017;2017:9029327
pubmed: 29386753
Mol Cell Biol. 2008 Sep;28(18):5687-97
pubmed: 18644866
Stroke. 2009 Oct;40(10):3342-8
pubmed: 19644058
Integr Biol (Camb). 2013 Dec;5(12):1474-84
pubmed: 24190477
J Immunol. 2004 Jul 1;173(1):123-35
pubmed: 15210766
J Biol Chem. 1996 Aug 30;271(35):21262-7
pubmed: 8702901
Int J Mol Sci. 2020 Oct 13;21(20):
pubmed: 33066042
Cell. 2003 Mar 7;112(5):645-57
pubmed: 12628185
J Thromb Haemost. 2009 Jul;7 Suppl 1:118-21
pubmed: 19630782
Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):37-48
pubmed: 26603156
J Cell Biol. 2007 Jun 18;177(6):1029-36
pubmed: 17562787
Mol Med Rep. 2018 Oct;18(4):3547-3554
pubmed: 30106145
Shock. 1995 Oct;4(4):233-40
pubmed: 8564549
J Lipid Res. 2009 Apr;50 Suppl:S97-102
pubmed: 19029065
Int J Mol Sci. 2017 Jul 17;18(7):
pubmed: 28714933
Cell Physiol Biochem. 2018;49(5):1677-1693
pubmed: 30231248
Stroke. 2012 Jan;43(1):199-204
pubmed: 21980199
Int J Mol Sci. 2020 Sep 29;21(19):
pubmed: 33003377
Nature. 2010 Jun 24;465(7301):1084-8
pubmed: 20577214
Science. 2001 Apr 20;292(5516):468-72
pubmed: 11292861
J Biomed Mater Res A. 2021 May;109(5):695-712
pubmed: 32608188
Dev Biol. 2004 Apr 15;268(2):441-7
pubmed: 15063179
Front Pharmacol. 2019 Jul 23;10:807
pubmed: 31427962
Antioxidants (Basel). 2021 Feb 19;10(2):
pubmed: 33669824
Biochim Biophys Acta. 2008 Sep;1781(9):435-41
pubmed: 18675379
Cancer Cell Int. 2013 Apr 16;13:36
pubmed: 23590596
Biochem Biophys Res Commun. 2012 Mar 16;419(3):466-71
pubmed: 22424098
FASEB J. 2011 Feb;25(2):600-12
pubmed: 20959514
Int J Biochem Cell Biol. 1997 Jan;29(1):63-78
pubmed: 9076942
FASEB J. 2011 Jul;25(7):2408-17
pubmed: 21450910
Antioxid Redox Signal. 2005 May-Jun;7(5-6):560-77
pubmed: 15890001
Cell Metab. 2006 Mar;3(3):177-85
pubmed: 16517405
J Biol Chem. 2003 Aug 8;278(32):30125-35
pubmed: 12761217
Cell Microbiol. 2018 May;20(5):e12836
pubmed: 29498184
Semin Cancer Biol. 2009 Feb;19(1):12-6
pubmed: 19114105
Pharmacol Ther. 2016 Dec;168:143-157
pubmed: 27621206
PLoS One. 2011;6(9):e25213
pubmed: 21980400
Cancer Biol Ther. 2012 Sep;13(11):1102-11
pubmed: 22895065
Trends Cell Biol. 2005 Nov;15(11):599-607
pubmed: 16202600
J Biol Chem. 2009 Nov 27;284(48):33185-94
pubmed: 19801684
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22
pubmed: 17609368
N Engl J Med. 2016 May 5;374(18):1754-62
pubmed: 27144850
Curr Pharm Des. 2009;15(33):3867-77
pubmed: 19671044
Free Radic Biol Med. 2020 Nov 1;159:136-149
pubmed: 32738398
PLoS One. 2013 Jun 18;8(6):e66189
pubmed: 23824493
Cancer Res. 2007 Nov 15;67(22):10823-30
pubmed: 18006827
Mol Cell Biochem. 2016 Mar;414(1-2):57-66
pubmed: 26899709
Nat Rev Immunol. 2017 Dec;17(12):774-785
pubmed: 28972206
Cancer Cell. 2004 Nov;6(5):485-95
pubmed: 15542432
Biochim Biophys Acta. 2004 Jun 1;1682(1-3):112-9
pubmed: 15158762
Annu Rev Immunol. 2012;30:69-94
pubmed: 22149932
Genes Dev. 1997 Jan 1;11(1):72-82
pubmed: 9000051
PLoS One. 2015 Oct 20;10(10):e0122771
pubmed: 26485657
Trends Biochem Sci. 2016 May;41(5):395-409
pubmed: 27021309
Nature. 2001 Nov 29;414(6863):550-4
pubmed: 11734856
J Dent Res. 2012 Sep;91(9):871-6
pubmed: 22821237
Mol Biol Cell. 2003 Aug;14(8):3470-81
pubmed: 12925778
Nat Med. 2000 Oct;6(10):1147-53
pubmed: 11017147
J Photochem Photobiol B. 2018 Sep;186:31-40
pubmed: 30005204
J Biol Chem. 2006 Nov 3;281(44):33095-106
pubmed: 16954218
Arch Oral Biol. 2015 Feb;60(2):272-81
pubmed: 25463905
PLoS One. 2014 Sep 04;9(9):e106487
pubmed: 25188469
Oncotarget. 2015 Jan 1;6(1):130-43
pubmed: 25426557
J Autoimmun. 2019 Dec;105:102290
pubmed: 31202617
Nat Rev Immunol. 2009 Sep;9(9):609-17
pubmed: 19704417