Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine
Animals
Antiviral Agents
/ analysis
Chlorocebus aethiops
Culture Techniques
Drug Screening Assays, Antitumor
Esters
/ metabolism
Genome, Bacterial
Glycolipids
/ chemistry
Humans
Metabolome
Microbial Sensitivity Tests
Molecular Structure
PC-3 Cells
Rhodococcus
/ chemistry
Succinates
/ metabolism
Surface-Active Agents
/ chemistry
Vero Cells
OSMAC approach
antiproliferative
antiviral
biosurfactant
glycolipids
marine bacteria
mass spectrometry
metabolomics
microbial natural products
trehalolipids
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Aug 2021
22 Aug 2021
Historique:
received:
19
07
2021
revised:
13
08
2021
accepted:
19
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
30
9
2021
Statut:
epublish
Résumé
Natural products of microbial origin have inspired most of the commercial pharmaceuticals, especially those from Actinobacteria. However, the redundancy of molecules in the discovery process represents a serious issue. The untargeted approach, One Strain Many Compounds (OSMAC), is one of the most promising strategies to induce the expression of silent genes, especially when combined with genome mining and advanced metabolomics analysis. In this work, the whole genome of the marine isolate
Identifiants
pubmed: 34445761
pii: ijms22169055
doi: 10.3390/ijms22169055
pmc: PMC8396431
pii:
doi:
Substances chimiques
Antiviral Agents
0
Esters
0
Glycolipids
0
Succinates
0
Surface-Active Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : H2020 Societal Challenges
ID : 101000794
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