Initial antimicrobial management of sepsis.
Antibiotic therapy
Antimicrobial therapy
Bacteremia
Biomarkers
Fungal infection
Intra-abdominal infection
Pharmacokinetics
Pneumonia
Sepsis
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
26 08 2021
26 08 2021
Historique:
received:
16
08
2021
accepted:
18
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Sepsis is a common consequence of infection, associated with a mortality rate > 25%. Although community-acquired sepsis is more common, hospital-acquired infection is more lethal. The most common site of infection is the lung, followed by abdominal infection, catheter-associated blood steam infection and urinary tract infection. Gram-negative sepsis is more common than gram-positive infection, but sepsis can also be due to fungal and viral pathogens. To reduce mortality, it is necessary to give immediate, empiric, broad-spectrum therapy to those with severe sepsis and/or shock, but this approach can drive antimicrobial overuse and resistance and should be accompanied by a commitment to de-escalation and antimicrobial stewardship. Biomarkers such a procalcitonin can provide decision support for antibiotic use, and may identify patients with a low likelihood of infection, and in some settings, can guide duration of antibiotic therapy. Sepsis can involve drug-resistant pathogens, and this often necessitates consideration of newer antimicrobial agents.
Identifiants
pubmed: 34446092
doi: 10.1186/s13054-021-03736-w
pii: 10.1186/s13054-021-03736-w
pmc: PMC8390082
doi:
Substances chimiques
Anti-Infective Agents
0
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
307Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. The Author(s).
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