Likelihood of prior exposure to circulating influenza viruses resulting in cross-protection by CD8+ T cells against emergent H3N2v swine viruses infecting humans.
Adolescent
Adult
Aged
Animals
B-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Child
Child, Preschool
Cross Protection
Disease Outbreaks
Female
Humans
Infant
Influenza A Virus, H3N2 Subtype
/ genetics
Influenza, Human
/ immunology
Male
Middle Aged
Orthomyxoviridae Infections
/ immunology
Retrospective Studies
Swine
T-Lymphocytes, Cytotoxic
/ immunology
Young Adult
H3N2v
cross-protection
immunogenic
influenza
peptides
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
01
07
2021
accepted:
25
08
2021
pubmed:
28
8
2021
medline:
10
2
2022
entrez:
27
8
2021
Statut:
ppublish
Résumé
Outbreaks of influenza in swine can result in potential threats to human public health. A notable occurrence was the emergence of swine-origin H1N1 influenza viruses in 2009. Since then, there have been several documented outbreaks of swine-origin influenza infecting humans in several countries. Sustained events have occurred when H1N1v, H1N2v, and H3N2v swine-origin viruses have infected humans visiting agricultural shows in the US. The predominant H3N2v viruses gained the matrix protein from the A(H1N1)pdm09 viruses, with reported human-to-human transmission raising fears of another pandemic. Current vaccines do not induce secondary cell-mediated immune responses, which may provide cross-protection against novel influenza A subtypes, however, population susceptibility to infection with seasonal influenza is likely to be influenced by cross-reactive CD8+ T-cells directed towards immunogenic peptides derived from viral proteins. This study involved a retrospective review of historical influenza viruses circulating in human populations from 1918 to 2020 to identify evidence of prior circulation of H3N3v immunogenic CD8+ T-cells peptides found in the NP and M1 proteins. We found evidence of prior circulation of H3N2v NP and M1 immunogenic peptides in historical influenza viruses. This provides insight into the population context in which influenza viruses emerge and may help inform immunogenic peptide selection for cytotoxic T-cell lymphocytes (CTL)-inducing influenza vaccines. Next-generation vaccines capable of eliciting CD8+ T-cell-mediated cross-protective immunity may offer a long-term alternative strategy for influenza vaccines.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
567-574Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Lee VJ, Ho ZJM, Goh EH, et al. Advances in measuring influenza burden of disease. Influenza Other Respir Viruses. 2018;12(1):3-9.
Rajao DS, Vincent AL, Perez DR. Adaptation of human influenza viruses to swine. Front Vet Sci. 2019;5:347.
Gaydos JC, Top FH, Hodder RA, Russell PK. Swine influenza a outbreak, Fort Dix, New Jersey, 1976. Emerging Infect Dis. 2006;12(1):23-28.
Gabriele N, Takeshi N, Yoshihiro K. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature. 2009;459(7249):931-939.
Komadina N, McVernon J, Hall R, Leder K. A historical perspective of influenza A(H1N2) virus. Emerging Infect Dis. 2014;20(1):6-12.
Centers for Disease Control. Update: influenza activity-United States and worldwide, May 20-September 22, 201. Morb Mortal Wkly Rep. 2012;61(39):785-789.
Houser KV, Katz JM, Tumpey TM. Seasonal trivalent inactivated influenza vaccine does not protect against newly emerging variants of influenza A (H3N2v) virus in ferrets. J Virol. 2013;87(2):1261-1263.
Biggerstaff M, Reed C, Epperson S, et al. Estimates of the number of human infections with influenza A (H3N2) variant virus, United States, August 2011-April 2012. Clin Infect Dis. 2013;57(suppl 1):S12-S15.
Stewart RJ, Rossow J, Conover JT, et al. Do animal exhibitors support and follow recommendations to prevent transmission of variant influenza at agricultural fairs? A survey of animal exhibitor households after a variant influenza virus outbreak in Michigan. Zoonoses Public Health. 2018;65(1):195-201.
Richard JW, Sabrina LS, Scott LK, Philip JG, Sagar MG, Robert GW. Evolution of swine H3N2 influenza viruses in the United States. J Virol. 2000;74(18):8243-8251.
Chou Y-y, Albrecht RA, Pica N, et al. The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model. J Virol. 2011;85(21):11235-11241.
Lindstrom S, Garten R, Balish A, et al. Human infections with novel reassortant influenza A(H3N2)v viruses, United States. Emerging Infect Dis. 2011;18(5):834-837.
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF. Evasion of influenza A viruses from innate and adaptive immune responses. Viruses. 2012;4(9):1438-1476.
Nüssing S, Sant S, Koutsakos M, Subbarao K, Nguyen THO, Kedzierska K. Innate and adaptive T cells in influenza disease. Front Med. 2018;12(1):34-47.
Krammer F, Smith GJD, Fouchier RAM, et al. Influenza. Nature Rev Dis Primers. 2018;4(1):3.
Kelso A. CD4+ T cells limit the damage in influenza. Nature Med. 2012;18(2):200-202.
Hayward AC, Wang L, Goonetilleke N, et al. Natural T cell-mediated protection against seasonal and pandemic influenza. Results of the Flu Watch Cohort Study. Am J Respir Crit Care Med. 2015;191(12):1422-1431.
Sridhar S, Begom S, Bermingham A, et al. Cellular immune correlates of protection against symptomatic pandemic influenza. Nature Med. 2013;19(10):1305-1312.
Shu Y, McCauley J. GISAID: Global initiative on sharing all influenza data-from vision to reality. Euro Surveill. 2017;22(13):30494.
Quiñones-Parra S, Grant E, Loh L, et al. Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities. Proc Natl Acad Sci U S A. 2014;111(3):1049-1054.
R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria. 2018. https://www.R-project.org
Jhung MA, Epperson S, Biggerstaff M, et al. Outbreak of variant influenza A(H3N2) virus in the United States. Clin Infect Dis. 2013;57(12):1703-1712.
Influenza A (H3N2) variant virus-related hospitalizations: Ohio, 2012. Morb Mortal Wkly Rep. 2012;61:764-767.
Centers for Disease Control. Update: influenza activity-worldwide and recommendations for influenza vaccine composition for the 1990-91 influenza season. Morb Mortal Wkly Rep. 1990;39(17):293-296.
Brammer TL, Izurieta HS, Fukuda K, et al. Surveillance for influenza-United States, 1994-95, 1995-96, and 1996-97 seasons. Morb Mortal Wkly Rep. 2000;49(SS-3):13-28.
Influenza activity-worldwide and recommendations for influenza vaccine composition for the 1990-1991 influenza season. JAMA. 1990;263(22):3002-3006.
Brammer TL, Izurieta HS, Fukuda K, et al. Surveillance for influenza-United States, 1994-95, 1995-96, and 1996-97 seasons. MMWR CDC surveillance summaries. Morb Mortal Wkly Rep. 2000;49(3):13-28.
Mao H, Yen HL, Liu Y, Lau YL, Malik Peiris JS, Tu W. Conservation of T cell epitopes between seasonal influenza viruses and the novel influenza A H7N9 virus. Virologica Sinica. 2014;29(3):170-175.
Hancock K, Veguilla V, Lu X, et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med. 2009;361(20):1945-1952.
Verma N, Dimitrova M, Carter DM, et al. Influenza virus H1N1pdm09 infections in the young and old: evidence of greater antibody diversity and affinity for the hemagglutinin globular head domain (HA1 Domain) in the elderly than in young adults and children. J Virol. 2012;86(10):5515-5522.
Dowdle WR. Influenza A virus recycling revisited. Bull World Health Organ. 1999;77(10):820-828.
Ma W, Vincent AL, Gramer MR, et al. Identification of H2N3 influenza A viruses from swine in the United States. Proc Natl Acad Sci U S A. 2007;104(52):20949-20954.
Joseph U, Linster M, Suzuki Y, et al. Adaptation of pandemic H2N2 influenza A viruses in humans. J Virol. 2015;89(4):2442-2447.
Komadina N, Quiñones-Parra SM, Kedzierska K, et al. High conservation level of CD8 T cell immunogenic regions within an unusual H1N2 human influenza variant. J Med Virol. 2016;88:1725-1732.
Sridhar S, Begom S, Bermingham A, et al. Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults. Eur J Immunol. 2012;42(11):2913-2924.
Sridhar S. Heterosubtypic T-Cell immunity to influenza in humans: challenges for universal T-cell influenza vaccines. Front Immunol. 2016;7:195.
Rimmelzwaan GF, Kreijtz JH, Bodewes R, Fouchier RA, Osterhaus AD. Influenza virus CTL epitopes, remarkably conserved and remarkably variable. Vaccine. 2009;27(45):6363-6365.
Agrati C, Castilletti C, Cimini E, et al. Cellular and humoral cross-immunity against two H3N2v influenza strains in presumably unexposed healthy and HIV-infected subjects. PLoS One. 2014;9(8):e105651-e.