An Epitope Platform for Safe and Effective HTLV-1-Immunization: Potential Applications for mRNA and Peptide-Based Vaccines.
Amino Acid Sequence
Databases, Genetic
Epitope Mapping
Epitopes
/ chemistry
HTLV-I Infections
/ immunology
Human T-lymphotropic virus 1
/ chemistry
Humans
Immunization
RNA, Messenger
/ chemistry
Vaccines, Subunit
/ chemistry
Vaccines, Synthetic
/ chemistry
Viral Vaccines
/ chemistry
mRNA Vaccines
/ chemistry
HTLV-1
adjuvant
autoimmunity
peptide
similarity
vaccine
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
27 07 2021
27 07 2021
Historique:
received:
20
06
2021
revised:
12
07
2021
accepted:
21
07
2021
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
3
2
2022
Statut:
epublish
Résumé
Human T-cell lymphotropic virus type 1 (HTLV-1) infection affects millions of individuals worldwide and can lead to severe leukemia, myelopathy/tropical spastic paraparesis, and numerous other disorders. Pursuing a safe and effective immunotherapeutic approach, we compared the viral polyprotein and the human proteome with a sliding window approach in order to identify oligopeptide sequences unique to the virus. The immunological relevance of the viral unique oligopeptides was assessed by searching them in the immune epitope database (IEDB). We found that HTLV-1 has 15 peptide stretches each consisting of uniquely viral non-human pentapeptides which are ideal candidate for a safe and effective anti-HTLV-1 vaccine. Indeed, experimentally validated HTLV-1 epitopes, as retrieved from the IEDB, contain peptide sequences also present in a vast number of human proteins, thus potentially instituting the basis for cross-reactions. We found a potential for cross-reactivity between the virus and the human proteome and described an epitope platform to be used in order to avoid it, thus obtaining effective, specific, and safe immunization. Potential advantages for mRNA and peptide-based vaccine formulations are discussed.
Identifiants
pubmed: 34452327
pii: v13081461
doi: 10.3390/v13081461
pmc: PMC8402675
pii:
doi:
Substances chimiques
Epitopes
0
RNA, Messenger
0
Vaccines, Subunit
0
Vaccines, Synthetic
0
Viral Vaccines
0
mRNA Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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