The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
17 08 2021
Historique:
received: 20 07 2021
revised: 11 08 2021
accepted: 14 08 2021
entrez: 28 8 2021
pubmed: 29 8 2021
medline: 28 1 2022
Statut: epublish

Résumé

Cytoplasmic aggregation of the primarily nuclear TAR DNA-binding protein 43 (TDP-43) affects neurons in most amyotrophic lateral sclerosis (ALS) and approximately half of frontotemporal lobar degeneration (FTLD) cases. The cellular prion protein, PrP

Identifiants

pubmed: 34452489
pii: v13081625
doi: 10.3390/v13081625
pmc: PMC8402629
pii:
doi:

Substances chimiques

DNA-Binding Proteins 0
PrPC Proteins 0
Prion Proteins 0
Prnp protein, mouse 0
TARDBP protein, human 0
TDP-43 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Carlo Scialò (C)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), 34136 Trieste, Italy.

Luigi Celauro (L)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), 34136 Trieste, Italy.

Marco Zattoni (M)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), 34136 Trieste, Italy.

Thanh Hoa Tran (TH)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), 34136 Trieste, Italy.

Edoardo Bistaffa (E)

Unit of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.

Fabio Moda (F)

Unit of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.

Robert Kammerer (R)

Institute of Immunology, Friedrich-Loeffler Institute, 17493 Riems, Germany.

Emanuele Buratti (E)

Molecular Pathology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy.

Giuseppe Legname (G)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), 34136 Trieste, Italy.

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Classifications MeSH