Leydig Cell and Spermatogenesis.
Androgen receptor
Leydig cells
Sertoli cells
Spermatogenesis
Synthetic enzymes
Testosterone
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
1
9
2021
Statut:
ppublish
Résumé
Leydig cells of the testis have the capacity to synthesize androgen (mainly testosterone) from cholesterol. Adult Leydig cells are the cell type for the synthesis of testosterone, which is critical for spermatogenesis. At least four steroidogenic enzymes take part in testosterone synthesis: cytochrome P450 cholesterol side chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase, cytochrome P450 17α-hydroxylase/17,20-lyase and 17β-hydroxysteroid dehydrogenase isoform 3. Testosterone metabolic enzyme steroid 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase are expressed in some precursor Leydig cells. Androgen is transported by androgen-binding protein to Sertoli cells, where it binds to androgen receptor to regulate spermatogenesis.
Identifiants
pubmed: 34453734
doi: 10.1007/978-3-030-77779-1_6
doi:
Substances chimiques
Androgens
0
Testosterone
3XMK78S47O
Steroid 17-alpha-Hydroxylase
EC 1.14.14.19
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111-129Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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