Osteoinductive potential of recombinant BMP-9 in bone defects of mice treated with antiresorptive agents.

Animals Bone Density Conservation Agents / pharmacology Bone Morphogenetic Protein 2 / pharmacology Bone Regeneration Growth Differentiation Factor 2 / pharmacology Mice Recombinant Proteins / pharmacology Transforming Growth Factor beta / pharmacology X-Ray Microtomography
BMP-9 antiresorptive agents bone morphogenetic proteins bone regeneration denosumab

Journal

International journal of oral and maxillofacial surgery
ISSN: 1399-0020
Titre abrégé: Int J Oral Maxillofac Surg
Pays: Denmark
ID NLM: 8605826

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 12 02 2021
revised: 19 05 2021
accepted: 12 08 2021
pubmed: 30 8 2021
medline: 15 3 2022
entrez: 29 8 2021
Statut: ppublish

Résumé

The aim of the present study was to investigate the effects of recombinant human (rh)BMP-9 on bone regenerative potential in a mouse model of antibody-mediated antiresorptive therapy (AMART). A monoclonal anti-murine receptor activator of nuclear factor-kappa B ligand (RANKL) antibody (mAb) was used to create an AMART model in mice. rhBMP-9 combined with collagen membrane was implanted in calvarial defects in mAb-treated mice. After 4 weeks, the bone formative potential in the defects was evaluated by micro-computed tomography and histological approaches. The groups implanted with rhBMP-9-containing collagen membranes demonstrated substantial osteopromotive potential, with significantly greater new bone volume (Sham + BMP-9 group; 0.86 ± 0.29 mm

Identifiants

DOI: 10.1016/j.ijom.2021.08.014 PMID: 34454793
pubmed: 34454793
pii: S0901-5027(21)00289-7
doi: 10.1016/j.ijom.2021.08.014
pii:
doi:

Substances chimiques

Bone Density Conservation Agents 0
Bone Morphogenetic Protein 2 0
Growth Differentiation Factor 2 0
Recombinant Proteins 0
Transforming Growth Factor beta 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

566-575

Informations de copyright

Copyright © 2021 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Auteurs

M Fujioka-Kobayashi (M)

Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Oral and Maxillofacial Surgery, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan. Electronic address: masako.kobayashi@tky.ndu.ac.jp.

S D Marjanowski (SD)

Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

M Kono (M)

Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.

S Hino (S)

Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

N Saulacic (N)

Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

B Schaller (B)

Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Osteoinductive potential of recombinant BMP-9...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents de maintien de la densité osseuse › Osteoinductive potential of recombinant BMP-9...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › Protéine morphogénétique osseuse de type 2 › Osteoinductive potential of recombinant BMP-9...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Régénération osseuse › Osteoinductive potential of recombinant BMP-9...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteurs de croissance et de différenciation › Facteur-2 de croissance et de différenciation › Osteoinductive potential of recombinant BMP-9...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Osteoinductive potential of recombinant BMP-9...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Osteoinductive potential of recombinant BMP-9...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Osteoinductive potential of recombinant BMP-9...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Microtomographie aux rayons X › Osteoinductive potential of recombinant BMP-9...