Team Evans and Watkins: Excitatory Amino Acid research at Bristol University 1973-1981.
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
pubmed:
30
8
2021
medline:
5
2
2022
entrez:
29
8
2021
Statut:
ppublish
Résumé
A series of Special Issues of Neuropharmacology celebrates the 40th anniversary of a seminal review on excitatory amino acid (EAA) receptors by two pioneers of the field - Dick Evans and Jeff Watkins. Brought together in the Department of Pharmacology at the University of Bristol in the 1970s, they forged a partnership that, through the synthetic chemistry prowess of Jeff Watkins, which provided novel agonists and antagonists for EAA receptors for Dick Evans's deft experimental studies, generated enormous insight into the multitude of actions of EAAs in the nervous system. Among many achievements from this time was not just the naming of the N-methyl-d-aspartate (NMDA) receptor, but also the demonstration of its antagonism by magnesium ions. Here, Dick and Jeff reflect upon those early halcyon days of EAA research, which, as these six
Identifiants
pubmed: 34454911
pii: S0028-3908(21)00323-3
doi: 10.1016/j.neuropharm.2021.108768
pii:
doi:
Substances chimiques
Excitatory Amino Acid Antagonists
0
Excitatory Amino Acids
0
Receptors, Glutamate
0
Types de publication
Editorial
Historical Article
Introductory Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108768Informations de copyright
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