Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke.
Age Factors
Aged
Aged, 80 and over
Anticoagulants
/ therapeutic use
COVID-19
/ complications
Case-Control Studies
Female
Functional Status
Humans
Ischemic Stroke
/ complications
Logistic Models
Male
Middle Aged
Mortality
Multivariate Analysis
Prognosis
Prospective Studies
SARS-CoV-2
Severity of Illness Index
Thrombectomy
Thrombolytic Therapy
cerebrovascular disease
coronavirus
pandemics
prognosis
reperfusion
stroke
thrombectomy
Journal
Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
pubmed:
31
8
2021
medline:
15
12
2021
entrez:
30
8
2021
Statut:
ppublish
Résumé
We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic stroke with or without coronavirus disease 2019 (COVID-19) infection. A prospective, observational, multicentre cohort study in Catalonia, Spain. Recruitment was consecutive from mid-March to mid-May 2020. Patients had an acute ischemic stroke within 48 hours and a previous modified Rankin Scale (mRS) score of 0 to 3. We collected demographic data, vascular risk factors, prior mRS score, National Institutes of Health Stroke Scale score, rate of reperfusion therapies, logistics, and metrics. Primary end point was functional outcome at 3 months. Favourable outcome was defined depending on the previous mRS score. Secondary outcome was mortality at 3 months. We performed mRS shift and multivariable analyses. We evaluated 701 patients (mean age 72.3±13.3 years, 60.5% men) and 91 (13%) had COVID-19 infection. Median baseline National Institutes of Health Stroke Scale score was higher in patients with COVID-19 compared with patients without COVID-19 (8 [3-18] versus 6 [2-14], Patients with ischemic stroke and COVID-19 infection have more severe strokes and a higher mortality than patients with stroke without COVID-19 infection. However, functional outcome is comparable in both groups.
Sections du résumé
BACKGROUND AND PURPOSE
We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic stroke with or without coronavirus disease 2019 (COVID-19) infection.
METHODS
A prospective, observational, multicentre cohort study in Catalonia, Spain. Recruitment was consecutive from mid-March to mid-May 2020. Patients had an acute ischemic stroke within 48 hours and a previous modified Rankin Scale (mRS) score of 0 to 3. We collected demographic data, vascular risk factors, prior mRS score, National Institutes of Health Stroke Scale score, rate of reperfusion therapies, logistics, and metrics. Primary end point was functional outcome at 3 months. Favourable outcome was defined depending on the previous mRS score. Secondary outcome was mortality at 3 months. We performed mRS shift and multivariable analyses.
RESULTS
We evaluated 701 patients (mean age 72.3±13.3 years, 60.5% men) and 91 (13%) had COVID-19 infection. Median baseline National Institutes of Health Stroke Scale score was higher in patients with COVID-19 compared with patients without COVID-19 (8 [3-18] versus 6 [2-14],
CONCLUSIONS
Patients with ischemic stroke and COVID-19 infection have more severe strokes and a higher mortality than patients with stroke without COVID-19 infection. However, functional outcome is comparable in both groups.
Identifiants
pubmed: 34455823
doi: 10.1161/STROKEAHA.121.034883
pmc: PMC8607902
doi:
Substances chimiques
Anticoagulants
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3908-3917Références
JAMA. 2020 May 26;323(20):2052-2059
pubmed: 32320003
JAMA Cardiol. 2020 Jul 1;5(7):751-753
pubmed: 32219362
N Engl J Med. 2020 Oct 29;383(18):1757-1766
pubmed: 32329974
Stroke. 2020 Jul;51(7):2002-2011
pubmed: 32432996
Front Med (Lausanne). 2021 Feb 05;8:620044
pubmed: 33634150
Stroke. 2020 Aug;51(8):2307-2314
pubmed: 32466738
Stroke. 2020 Jul;51(7):1991-1995
pubmed: 32438895
Lancet. 2020 May 30;395(10238):1715-1725
pubmed: 32405103
Int J Stroke. 2020 Jul;15(5):540-554
pubmed: 32362244
Stroke. 1993 Jan;24(1):35-41
pubmed: 7678184
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
J Neurol. 2020 Aug;267(8):2185-2192
pubmed: 32436105
Neurology. 2020 Dec 15;95(24):e3373-e3385
pubmed: 32934172
Aging (Albany NY). 2020 May 29;12(10):9959-9981
pubmed: 32470948
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Stroke. 2011 May;42(5):1482-8
pubmed: 21474812
J Microbiol Immunol Infect. 2021 Apr;54(2):164-174
pubmed: 32513617
Lancet Infect Dis. 2021 Jun;21(6):e163-e169
pubmed: 33301725
Stroke. 2020 Dec;51(12):3570-3576
pubmed: 33106109
Stroke. 2020 Jul;51(7):e124-e127
pubmed: 32396456
Stroke. 2020 Jul;51(7):1924-1926
pubmed: 32496937
Stroke Vasc Neurol. 2020 Sep;5(3):279-284
pubmed: 32616524
J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):889-891
pubmed: 32354768
Stroke. 2020 Jul;51(7):2219-2223
pubmed: 32466735
Neurology. 2020 Aug 25;95(8):e1060-e1070
pubmed: 32482845
J Am Coll Cardiol. 2020 Jun 16;75(23):2950-2973
pubmed: 32311448
Lancet. 2020 Jun 6;395(10239):1763-1770
pubmed: 32442528
Stroke. 2020 Jul;51(7):1996-2001
pubmed: 32432997
Stroke. 2020 Jun;51(6):1910-1912
pubmed: 32233972
N Engl J Med. 2020 May 14;382(20):e60
pubmed: 32343504