Nuclear envelope mechanobiology: linking the nuclear structure and function.
Nuclear envelope
chromatin
live imaging
mechanobiology
nuclear mechanics
Journal
Nucleus (Austin, Tex.)
ISSN: 1949-1042
Titre abrégé: Nucleus
Pays: United States
ID NLM: 101518322
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
14
1
2022
Statut:
ppublish
Résumé
The nucleus, central to cellular activity, relies on both direct mechanical input as well as its molecular transducers to sense external stimuli and respond by regulating intra-nuclear chromatin organization that determines cell function and fate. In mesenchymal stem cells of musculoskeletal tissues, changes in nuclear structures are emerging as a key modulator of their differentiation and proliferation programs. In this review we will first introduce the structural elements of the nucleoskeleton and discuss the current literature on how nuclear structure and signaling are altered in relation to environmental and tissue level mechanical cues. We will focus on state-of-the-art techniques to apply mechanical force and methods to measure nuclear mechanics in conjunction with DNA, RNA, and protein visualization in living cells. Ultimately, combining real-time nuclear deformations and chromatin dynamics can be a powerful tool to study mechanisms of how forces affect the dynamics of genome function.
Identifiants
pubmed: 34455929
doi: 10.1080/19491034.2021.1962610
pmc: PMC8432354
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-114Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM109095
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059923
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM123446
Pays : United States
Références
Curr Protein Pept Sci. 2008 Aug;9(4):338-69
pubmed: 18691124
Nat Commun. 2017 Dec 14;8(1):2123
pubmed: 29242553
J Biol Chem. 2015 May 1;290(18):11209-16
pubmed: 25759381
Science. 2016 Apr 15;352(6283):353-8
pubmed: 27013428
Cell. 2015 Nov 5;163(4):880-93
pubmed: 26544937
Biotech Histochem. 1995 Sep;70(5):220-33
pubmed: 8580206
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21258-21266
pubmed: 32817542
Nanotechnology. 2011 Apr 29;22(17):175707
pubmed: 21411911
Biophys J. 2002 Aug;83(2):1184-93
pubmed: 12124298
Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118518
pubmed: 31376419
Methods Mol Biol. 2013;1042:47-60
pubmed: 23979999
Nat Methods. 2006 Feb;3(2):83-9
pubmed: 16432516
J Cell Sci. 2012 May 1;125(Pt 9):2087-93
pubmed: 22669459
J Cell Biol. 2006 Jan 2;172(1):41-53
pubmed: 16380439
J Biomech. 2016 Dec 8;49(16):3983-3989
pubmed: 27836504
Trends Cell Biol. 1999 Feb;9(2):57-60
pubmed: 10087619
Physiol Rev. 2014 Jan;94(1):235-63
pubmed: 24382887
J Am Chem Soc. 2014 Nov 19;136(46):16299-308
pubmed: 25337688
Am J Physiol Cell Physiol. 2008 Oct;295(4):C1007-15
pubmed: 18701650
J Pediatr Endocrinol Metab. 2012;25(3-4):375-7
pubmed: 22768673
Nucleus. 2018;9(1):350-367
pubmed: 29943658
Nat Methods. 2008 Feb;5(2):159-61
pubmed: 18176568
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14353-8
pubmed: 18799748
Development. 1989 Feb;105(2):365-78
pubmed: 2680424
Endocrinology. 2008 Dec;149(12):6065-75
pubmed: 18687779
J Biol Chem. 2016 Aug 19;291(34):17829-47
pubmed: 27402842
Biophys J. 2012 Nov 7;103(9):L41-3
pubmed: 23199932
Biophys J. 2012 Dec 19;103(12):2423-31
pubmed: 23260044
Biomed Opt Express. 2019 Apr 15;10(5):2409-2418
pubmed: 31143496
J Biomech. 2007;40(4):786-94
pubmed: 16698026
Mol Cell Biol. 2015 Mar;35(5):884-98
pubmed: 25535332
NPJ Microgravity. 2020 Dec 1;6(1):35
pubmed: 33298964
J Orthop Res. 1995 May;13(3):410-21
pubmed: 7602402
Methods. 2018 May 1;140-141:10-22
pubmed: 29253641
Biochem Biophys Res Commun. 2007 Apr 13;355(3):835-41
pubmed: 17320816
J Cell Sci. 2005 Aug 1;118(Pt 15):3419-30
pubmed: 16079285
Nucleus. 2015;6(1):30-9
pubmed: 25602132
Cells. 2019 Jun 10;8(6):
pubmed: 31185657
Science. 2018 Jul 27;361(6400):
pubmed: 29930091
Nano Lett. 2018 Apr 11;18(4):2243-2253
pubmed: 29517915
EMBO J. 1993 Jan;12(1):97-106
pubmed: 8094052
Biophys J. 2002 May;82(5):2775-83
pubmed: 11964263
Science. 2016 Jun 17;352(6292):1425-9
pubmed: 27313040
Nature. 2013 May 23;497(7450):507-11
pubmed: 23644458
Science. 2013 Aug 9;341(6146):660-4
pubmed: 23929981
Nature. 2018 Jul;559(7712):54-60
pubmed: 29925946
J Biol Chem. 2012 Feb 17;287(8):5317-26
pubmed: 22170055
Biophys J. 2003 May;84(5):3353-63
pubmed: 12719264
Cell. 2020 May 14;181(4):800-817.e22
pubmed: 32302590
Biophys J. 2009 May 6;96(9):3832-9
pubmed: 19413989
Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1326-1334
pubmed: 29510091
ACS Biomater Sci Eng. 2017 Nov 13;3(11):2798-2805
pubmed: 29276759
Cell. 2017 Nov 30;171(6):1397-1410.e14
pubmed: 29107331
Nucleic Acids Res. 2018 Jun 20;46(11):5561-5586
pubmed: 29684168
Nucleic Acids Res. 1978 Oct;5(10):3775-99
pubmed: 31603
Cell. 2019 May 2;177(4):852-864.e14
pubmed: 30982597
EMBO J. 2011 Jun 1;30(11):2153-66
pubmed: 21499228
J Mol Biol. 1989 Aug 5;208(3):393-404
pubmed: 2795656
Methods Cell Biol. 1999;58:203-22
pubmed: 9891383
Sci Rep. 2015 Oct 27;5:15538
pubmed: 26503225
Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E32-40
pubmed: 26699462
Nat Cell Biol. 2014 Apr;16(4):376-81
pubmed: 24609268
J Cell Biol. 2005 Dec 5;171(5):799-810
pubmed: 16330710
J Biomech. 2020 Oct 9;111:110012
pubmed: 32932075
Cell. 2013 Dec 19;155(7):1479-91
pubmed: 24360272
J Cell Sci. 2019 Jun 12;132(11):
pubmed: 31076516
J Biol Chem. 2020 May 8;295(19):6289-6298
pubmed: 32156700
J Cell Biol. 2013 Sep 30;202(7):1023-39
pubmed: 24062341
Mol Cell. 2019 Dec 19;76(6):981-997.e7
pubmed: 31757757
Biochemistry. 2007 Jul 31;46(30):8897-908
pubmed: 17620012
J Histochem Cytochem. 1975 Jul;23(7):493-505
pubmed: 1095650
Curr Protoc Hum Genet. 2013 Jan;Chapter 4:Unit 4.15
pubmed: 23315927
Nucleus. 2019 Dec;10(1):33-41
pubmed: 30755082
Science. 2014 Oct 24;346(6208):1257998
pubmed: 25342811
Biophys J. 2008 Jan 15;94(2):L14-6
pubmed: 17981902
Biochem Soc Trans. 2003 Oct;31(Pt 5):997-1000
pubmed: 14505467
Biophys J. 2013 Nov 19;105(10):2252-61
pubmed: 24268137
Cell. 2020 Dec 23;183(7):1772-1784.e13
pubmed: 33326747
Curr Opin Cell Biol. 2011 Feb;23(1):47-54
pubmed: 21177090
Semin Cell Dev Biol. 2017 Aug;68:52-58
pubmed: 28676424
Cell Rep. 2019 Apr 30;27(5):1607-1620.e4
pubmed: 31042484
Biophys J. 1999 Oct;77(4):2251-65
pubmed: 10512844
Annu Rev Cell Biol. 1988;4:487-525
pubmed: 3058164
J Cell Biol. 2010 Mar 22;188(6):877-90
pubmed: 20308429
Small. 2021 Feb;17(6):e2006699
pubmed: 33470544
Biophys J. 2005 Oct;89(4):2855-64
pubmed: 16055543
J Biochem. 2018 Oct 1;164(4):303-311
pubmed: 29878215
Hum Pathol. 2005 Oct;36(10):1049-54
pubmed: 16226103
Integr Biol (Camb). 2015 Oct;7(10):1309-17
pubmed: 26359759
J Struct Biol. 2004 Jul;147(1):31-41
pubmed: 15109603
Science. 2000 Oct 13;290(5490):337-41
pubmed: 11030652
EMBO Rep. 2020 Aug 5;21(8):e48779
pubmed: 32537912
J Clin Invest. 2004 Feb;113(3):370-8
pubmed: 14755334
Nat Photonics. 2015 Feb;9(2):113-119
pubmed: 25663846
Cell Mol Bioeng. 2017 Nov 16;11(1):53-64
pubmed: 31719878
Dev Biol. 2015 Nov 15;407(2):321-30
pubmed: 26417726
Ann Biomed Eng. 2005 Oct;33(10):1312-8
pubmed: 16240080
Nucleic Acids Res. 2020 Apr 17;48(7):3423-3434
pubmed: 32123910
J Cell Biol. 1990 Sep;111(3):1059-68
pubmed: 2118142
Cells. 2019 Mar 13;8(3):
pubmed: 30871242
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8531-4
pubmed: 2847165
Am J Physiol. 1998 Dec;275(6 Pt 1):C1591-601
pubmed: 9843721
Nucleus. 2015;6(1):8-14
pubmed: 25602590
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11870-5
pubmed: 26324940
ACS Chem Biol. 2014 Oct 17;9(10):2412-20
pubmed: 25101481
Biophys J. 2020 Jun 2;118(11):2627-2640
pubmed: 32407683
Biophys J. 2006 Sep 15;91(6):2297-303
pubmed: 16815897
Science. 2011 Jul 29;333(6042):642-6
pubmed: 21798953
Science. 1990 Aug 3;249(4968):505-10
pubmed: 2200121
Biophys J. 2005 Apr;88(4):2919-28
pubmed: 15653748
Nature. 2008 Jun 12;453(7197):948-51
pubmed: 18463634
Int J Biol Macromol. 2006 Aug 15;39(1-3):66-76
pubmed: 16503347
Dev Cell. 2019 Dec 2;51(5):602-616.e12
pubmed: 31794718
J Cell Sci. 2003 Mar 1;116(Pt 5):823-35
pubmed: 12571280
J Cell Sci. 2012 Jul 1;125(Pt 13):3061-73
pubmed: 22797927
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19017-22
pubmed: 19850871
Tissue Eng Part B Rev. 2012 Dec;18(6):436-44
pubmed: 22741572
Small. 2021 Feb;17(5):e2006109
pubmed: 33448065
J Cell Biol. 2014 Mar 3;204(5):669-82
pubmed: 24567359
J Cell Biol. 1996 Dec;135(6 Pt 2):1685-700
pubmed: 8991083
Science. 2011 Apr 22;332(6028):475-8
pubmed: 21512033
Curr Biol. 2018 Oct 8;28(19):3086-3097.e4
pubmed: 30245107
Cancer Res. 2018 Nov 1;78(21):6086-6097
pubmed: 30154147
FEBS Lett. 2002 Aug 14;525(1-3):135-40
pubmed: 12163176
Sci Rep. 2014 Apr 09;4:4610
pubmed: 24714394
Sci Rep. 2019 Jun 24;9(1):9086
pubmed: 31235788
Biochim Biophys Acta. 2002 Feb 15;1570(1):1-8
pubmed: 11960682
Reproduction. 2018 Jan;155(1):61-71
pubmed: 29066531
Curr Biol. 1998 Dec 17-31;8(25):1347-56
pubmed: 9889097
Nat Photonics. 2007 Dec 9;2:39-43
pubmed: 19812712
J Biol Chem. 2010 Jan 29;285(5):3487-98
pubmed: 19933576
Genes Dev. 2013 Aug 15;27(16):1787-99
pubmed: 23934658
J Cell Biol. 2007 Aug 27;178(5):785-98
pubmed: 17724119
Exp Biol Med (Maywood). 2018 Mar;243(6):507-524
pubmed: 29557213
J Med Chem. 2020 Mar 12;63(5):2209-2228
pubmed: 31369705
PLoS One. 2011;6(10):e25727
pubmed: 21998685
J Biol Chem. 2006 Sep 1;281(35):25768-80
pubmed: 16825190
Biophys J. 2005 Dec;89(6):4275-85
pubmed: 16150965
Traffic. 2001 Nov;2(11):764-74
pubmed: 11733042
Am J Physiol. 1995 Nov;269(5 Pt 1):C1093-104
pubmed: 7491896
Annu Rev Cell Dev Biol. 2005;21:247-69
pubmed: 16212495
Hum Mol Genet. 2004 Nov 1;13(21):2567-80
pubmed: 15367494
Nat Cell Biol. 2004 Dec;6(12):1165-72
pubmed: 15558034
J Cell Sci. 2011 May 1;124(Pt 9):1433-44
pubmed: 21486941
Nat Biotechnol. 2016 May;34(5):528-30
pubmed: 27088723
Nucleus. 2020 Dec;11(1):250-263
pubmed: 32954953
Mol Cell Biol. 2006 May;26(10):3738-51
pubmed: 16648470
Nat Commun. 2020 Mar 9;11(1):1283
pubmed: 32152311
Nat Protoc. 2010 Jun;5(6):1169-85
pubmed: 20539292
Cell. 2013 Feb 28;152(5):1173-83
pubmed: 23452860
Biochemistry. 2010 Feb 2;49(4):772-81
pubmed: 20039662
Nat Cell Biol. 2016 Aug;18(8):864-75
pubmed: 27398909
Methods. 2003 Jan;29(1):74-85
pubmed: 12543073
Nat Commun. 2020 May 1;11(1):2120
pubmed: 32358536
Curr Opin Genet Dev. 2006 Apr;16(2):191-6
pubmed: 16495046
Biophys J. 2005 Aug;89(2):1317-27
pubmed: 15908582
Biophys J. 1991 Oct;60(4):910-21
pubmed: 1742458
Phys Rev Lett. 2000 Jul 24;85(4):888-91
pubmed: 10991424
Genes Dev. 2008 Jul 15;22(14):1962-71
pubmed: 18579750
J Biol Chem. 2009 Dec 11;284(50):34607-17
pubmed: 19840939
J Cell Biol. 2007 Sep 10;178(6):897-904
pubmed: 17785515
Mol Biol Cell. 2017 Nov 7;28(23):3333-3348
pubmed: 28931598
J Biol Chem. 2011 Jul 29;286(30):26743-53
pubmed: 21652697
Biophys J. 2016 Jan 5;110(1):34-43
pubmed: 26745407
Methods Mol Biol. 2018;1861:91-102
pubmed: 30218362
EMBO J. 2019 Jun 17;38(12):
pubmed: 31101674
Nat Struct Mol Biol. 2007 Sep;14(9):796-806
pubmed: 17676063
Biophys J. 2012 Oct 3;103(7):1416-28
pubmed: 23062334
Nat Commun. 2012 Feb 14;3:671
pubmed: 22334074
Folia Histochem Cytobiol. 2006;44(4):231-48
pubmed: 17219717
Biophys J. 2013 Feb 5;104(3):553-64
pubmed: 23442906
Methods Mol Biol. 2016;1411:407-17
pubmed: 27147056
Biophys J. 2006 Sep 1;91(5):1915-24
pubmed: 16782786
Biorheology. 2002;39(1-2):69-78
pubmed: 12082269
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):861-866
pubmed: 29339488
Exp Cell Res. 2007 Jun 10;313(10):2167-79
pubmed: 17451680
Nat Struct Mol Biol. 2013 Apr;20(4):426-32
pubmed: 23524535
Exp Cell Res. 2016 Jul 15;345(2):168-79
pubmed: 27321956
Methods. 2016 Feb 1;94:19-26
pubmed: 26427549
Nature. 2010 Jul 8;466(7303):263-6
pubmed: 20613844
PLoS Biol. 2004 Sep;2(9):E231
pubmed: 15328537
Nat Cell Biol. 2006 Mar;8(3):257-63
pubmed: 16489345
Mol Biol Cell. 2017 Jul 7;28(14):1984-1996
pubmed: 28057760
J Cell Biol. 1981 Apr;89(1):141-5
pubmed: 7014571
J R Soc Interface. 2015 Mar 6;12(104):20141351
pubmed: 25589570
Am J Physiol Cell Physiol. 2011 Apr;300(4):C723-42
pubmed: 21209361
J Biomech. 2011 Feb 24;44(4):593-9
pubmed: 21130997
Biotechniques. 2008 Jul;45(1):33-52, 56-62
pubmed: 18611167
Science. 2013 Aug 30;341(6149):1240104
pubmed: 23990565
Curr Chem Genomics. 2012;6:8-17
pubmed: 23115610
Sci Rep. 2019 Oct 7;9(1):14401
pubmed: 31591420
Mol Cell. 2019 Sep 19;75(6):1161-1177.e11
pubmed: 31421980
Curr Biol. 2014 Sep 8;24(17):2012-7
pubmed: 25127217
Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct;1(2):273-282
pubmed: 20835996
J Cell Biol. 1999 Nov 29;147(5):913-20
pubmed: 10579712
Sci Rep. 2014 Dec 08;4:7362
pubmed: 25482017
Sci Rep. 2016 Feb 04;6:20408
pubmed: 26842404
Nat Methods. 2007 Nov;4(11):963-73
pubmed: 17971781
Chin J Cancer. 2011 Jun;30(6):415-25
pubmed: 21627864
Cell Rep. 2020 Jul 21;32(3):107924
pubmed: 32697990
Stem Cells. 2015 Jun;33(6):2063-76
pubmed: 25787126
Integr Biol (Camb). 2012 Sep;4(9):1102-11
pubmed: 22814412
Int J Mol Sci. 2021 Jun 19;22(12):
pubmed: 34205295
J Cell Sci. 2001 Dec;114(Pt 24):4485-98
pubmed: 11792814
Methods Mol Biol. 2012;833:177-200
pubmed: 22183595
Mol Biol Cell. 2018 Jan 15;29(2):220-233
pubmed: 29142071
Mol Biol Cell. 2013 Dec;24(24):3869-80
pubmed: 24152738
Biochem Biophys Res Commun. 1974 Oct 23;60(4):1410-7
pubmed: 4214419
Nature. 2010 Nov 25;468(7323):580-4
pubmed: 21107430
Nat Rev Mol Cell Biol. 2011 Oct 05;12(11):695-708
pubmed: 21971041
J Biomech. 2018 Jun 6;74:32-40
pubmed: 29691054
Biopolymers. 1974 Jan;13(1):29-61
pubmed: 4818131
Methods Appl Fluoresc. 2016 Nov 11;4(4):044008
pubmed: 28192301
Elife. 2014 Oct 01;3:
pubmed: 25271374
Nat Rev Mol Cell Biol. 2013 Jan;14(1):13-24
pubmed: 23212477
Sci Rep. 2013;3:1087
pubmed: 23336069
Arch Oral Biol. 2020 Oct;118:104860
pubmed: 32791354
Int J Mol Med. 2016 Nov;38(5):1531-1540
pubmed: 28026000
Science. 2015 May 29;348(6238):1024-7
pubmed: 26023140
J Vis Exp. 2018 Jul 3;(137):
pubmed: 30035766
Nat Mater. 2016 Dec;15(12):1287-1296
pubmed: 27548707
Dev Cell. 2007 Jun;12(6):863-72
pubmed: 17543860
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Aug;25(4):845-8
pubmed: 18788293
J Biol Chem. 2011 Nov 11;286(45):39450-6
pubmed: 21956113
J Biomech. 2021 May 24;121:110400
pubmed: 33882444
J Biomech. 2013 Sep 27;46(14):2490-6
pubmed: 23992835
Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Dec;64(6 Pt 1):061506
pubmed: 11736190
J Orthop Res. 2011 Jan;29(1):20-5
pubmed: 20602472
J Biol Chem. 1993 Aug 5;268(22):16321-6
pubmed: 8344919
BMC Mol Cell Biol. 2019 May 22;20(1):11
pubmed: 31117946
Stem Cells. 2011 Nov;29(11):1829-36
pubmed: 21898699
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10428-33
pubmed: 15232008
Nucleus. 2010 May-Jun;1(3):264-72
pubmed: 21327074
Biomaterials. 2021 Mar;270:120662
pubmed: 33540172
Exp Physiol. 2010 Nov;95(11):1049-60
pubmed: 20696785
Nucleus. 2013 Jan-Feb;4(1):53-60
pubmed: 23324457
J Bone Miner Res. 2020 Jun;35(6):1149-1162
pubmed: 32022326
Elife. 2016 Oct 26;5:
pubmed: 27782880
Arch Oral Biol. 2016 Oct;70:47-54
pubmed: 27328150
Nat Protoc. 2014 Nov;9(11):2555-73
pubmed: 25299154
Science. 2017 Feb 10;355(6325):606-612
pubmed: 28008086
J Biomech. 2010 Jan 5;43(1):55-62
pubmed: 19800626
J Mol Biol. 1989 Aug 5;208(3):405-15
pubmed: 2477550
Sci Rep. 2016 May 27;6:26857
pubmed: 27229896
Curr Opin Cell Biol. 2019 Jun;58:76-84
pubmed: 30889417
PLoS One. 2010 May 28;5(5):e10874
pubmed: 20526372
Nat Methods. 2016 Dec;13(12):985-988
pubmed: 27776112
Curr Opin Cell Biol. 2002 Jun;14(3):357-64
pubmed: 12067659
Science. 2003 Jun 27;300(5628):2055
pubmed: 12702809
Methods. 2017 Jul 1;123:76-88
pubmed: 28315485
Science. 2003 Apr 4;300(5616):82-6
pubmed: 12677057
J Cell Biochem. 2008 Mar 1;103(4):1158-70
pubmed: 17661354
Nat Methods. 2019 Oct;16(10):1054-1062
pubmed: 31562489
Nat Commun. 2015 Jan 22;6:6138
pubmed: 25609380
Methods Enzymol. 2014;546:337-54
pubmed: 25398348
Cell. 2017 Mar 23;169(1):13-23
pubmed: 28340338
Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a000554
pubmed: 20452940
Biophys J. 2015 Jun 16;108(12):2783-93
pubmed: 26083918
PLoS Genet. 2014 Sep 11;10(9):e1004605
pubmed: 25210889
Nat Commun. 2015 Aug 24;6:8044
pubmed: 26299252
J Biomed Opt. 2020 May;25(7):1-43
pubmed: 32406215
Biochem Biophys Res Commun. 2000 Mar 24;269(3):781-6
pubmed: 10720492
J Biomech. 2011 Mar 15;44(5):930-4
pubmed: 21145552
J Bone Miner Res. 2014 Jan;29(1):78-89
pubmed: 23821483