Isolation and Identification of Isocoumarin Derivatives With Specific Inhibitory Activity Against Wnt Pathway and Metabolome Characterization of
Lasiodiplodia venezuelensis
Wnt pathway inhibitors
anticancer
bio-guided fractionation
endophytic fungi
isocoumarins
molecular networking
natural product
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
04
2021
accepted:
12
07
2021
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
The Wnt signaling pathway controls multiple events during embryonic development of multicellular animals and is carcinogenic when aberrantly activated in adults. Breast cancers are dependent on Wnt pathway overactivation mostly through dysregulation of pathway component protein expression, which necessitates the search for therapeutically relevant compounds targeting them. Highly diverse microorganisms as endophytes represent an underexplored field in the therapeutic natural products research. In the present work, the objective was to explore the chemical diversity and presence of selective Wnt inhibitors within a unique collection of fungi isolated as foliar endophytes from the long-lived tropical palm
Identifiants
pubmed: 34458231
doi: 10.3389/fchem.2021.664489
pii: 664489
pmc: PMC8397479
doi:
Types de publication
Journal Article
Langues
eng
Pagination
664489Informations de copyright
Copyright © 2021 Pellissier, Koval, Marcourt, Ferreira Queiroz, Lecoultre, Leoni, Quiros-Guerrero, Barthélémy, Duivelshof, Guillarme, Tardy, Eparvier, Perron, Chave, Stien, Gindro, Katanaev and Wolfender.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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