Autophagy in major human diseases.
aging
cancer
inflammation
metabolic syndromes
neurodegeneration
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
revised:
07
07
2021
received:
01
06
2021
accepted:
12
07
2021
pubmed:
31
8
2021
medline:
15
12
2021
entrez:
30
8
2021
Statut:
ppublish
Résumé
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Identifiants
pubmed: 34459017
doi: 10.15252/embj.2021108863
pmc: PMC8488577
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e108863Subventions
Organisme : NIA NIH HHS
ID : R01 AG021904
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/B/000C0413
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P01 CA114046
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/B/000C0417
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA260249
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131689
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064892
Pays : United States
Organisme : Medical Research Council
ID : UKDRI-2002
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA216242
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG038664
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA200310
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031782
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA251726
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM102846
Pays : United States
Informations de copyright
© 2021 The Authors. Published under the terms of the CC BY 4.0 license.
Références
Science. 2004 Aug 27;305(5688):1292-5
pubmed: 15333840
J Virol. 2012 Aug;86(16):8705-12
pubmed: 22674982
Mol Neurodegener. 2019 Nov 27;14(1):43
pubmed: 31775806
Lancet Public Health. 2019 Mar;4(3):e123-e124
pubmed: 30851865
Nat Rev Mol Cell Biol. 2020 Feb;21(2):101-118
pubmed: 31768005
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14489-94
pubmed: 17726112
Annu Rev Genet. 2009;43:67-93
pubmed: 19653858
Cancer Cell. 2018 Sep 10;34(3):361-378
pubmed: 30216189
Circulation. 2012 Jun 26;125(25):3170-81
pubmed: 22592897
Sci Adv. 2021 Jan 1;7(1):
pubmed: 33523841
EMBO Mol Med. 2021 Feb 5;13(2):e13158
pubmed: 33369168
JCI Insight. 2019 Dec 5;4(23):
pubmed: 31639106
Hum Mol Genet. 2019 Feb 15;28(4):615-627
pubmed: 30339187
Cancer Discov. 2013 Nov;3(11):1272-85
pubmed: 23965987
Am J Hum Genet. 2011 Jan 7;88(1):99-105
pubmed: 21194679
EMBO J. 2016 Jun 15;35(12):1276-97
pubmed: 27103069
Cell Rep. 2018 Nov 13;25(7):1708-1717.e5
pubmed: 30428342
Int Rev Cell Mol Biol. 2019;349:177-211
pubmed: 31759431
Autophagy. 2020 May;16(5):917-931
pubmed: 31362587
J Neurochem. 2009 Nov;111(4):1062-73
pubmed: 19765191
Autophagy. 2021 Oct;17(10):2842-2855
pubmed: 33172332
Autophagy. 2015;11(7):1130-45
pubmed: 26039325
Oncoimmunology. 2020 Aug 31;9(1):1809936
pubmed: 32939326
J Immunol. 2016 Jul 15;197(2):504-16
pubmed: 27279371
PLoS One. 2011 Apr 06;6(4):e18568
pubmed: 21494637
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9271-E9279
pubmed: 29078276
Cell Death Dis. 2016 Feb 18;7:e2097
pubmed: 26890136
Eur J Neurosci. 1996 Aug;8(8):1735-45
pubmed: 8921264
Oncoimmunology. 2019 May 16;8(10):e1616153
pubmed: 31646069
Nat Med. 2019 Apr;25(4):628-640
pubmed: 30833752
Am J Transl Res. 2017 Nov 15;9(11):4707-4725
pubmed: 29218074
Annu Rev Physiol. 2019 Feb 10;81:19-41
pubmed: 30216742
Nat Rev Clin Oncol. 2020 Dec;17(12):725-741
pubmed: 32760014
Nat Rev Genet. 2020 Feb;21(2):88-101
pubmed: 31690828
Nat Commun. 2015 Apr 10;6:6779
pubmed: 25858075
Nat Med. 2007 May;13(5):619-24
pubmed: 17450150
J Clin Invest. 2013 Dec;123(12):5212-30
pubmed: 24200693
Autophagy. 2014;10(12):2109-21
pubmed: 25426782
Neuroscience. 2015 Aug 27;302:89-102
pubmed: 25450953
J Immunol. 2010 Dec 15;185(12):7349-57
pubmed: 21059894
Cell. 2019 Jan 10;176(1-2):11-42
pubmed: 30633901
Nat Commun. 2020 Aug 18;11(1):4150
pubmed: 32811819
Exp Mol Med. 2019 Aug 13;51(8):1-11
pubmed: 31409770
Biochem Biophys Res Commun. 2021 Apr 30;551:148-154
pubmed: 33740621
Dev Cell. 2018 Nov 5;47(3):281-293.e4
pubmed: 30318245
J Biol Chem. 2007 Nov 2;282(44):32208-21
pubmed: 17761676
EMBO J. 2017 Jun 14;36(12):1688-1706
pubmed: 28465321
Sci Rep. 2014 Aug 11;4:6010
pubmed: 25109817
PLoS One. 2017 Feb 21;12(2):e0171940
pubmed: 28222108
Oncoimmunology. 2021 Feb 22;10(1):1887552
pubmed: 33680573
Nature. 2019 Feb;566(7743):264-269
pubmed: 30700906
Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20655-20665
pubmed: 31548426
J Hepatol. 2018 Mar;68(3):593-594
pubmed: 29373182
Autophagy. 2010 Jul;6(5):600-6
pubmed: 20431347
J Exp Med. 2017 Sep 4;214(9):2611-2628
pubmed: 28778989
Nat Cell Biol. 2018 Dec;20(12):1338-1348
pubmed: 30482941
J Immunother Cancer. 2020 Mar;8(1):
pubmed: 32209603
Nat Cell Biol. 2012 Oct;14(10):1024-35
pubmed: 23023224
Autophagy. 2015 Apr 3;11(4):670-84
pubmed: 25906080
Nature. 2008 Nov 13;456(7219):259-63
pubmed: 18849966
Nature. 2016 Aug 25;536(7617):479-83
pubmed: 27509858
Mol Cell. 2020 Jul 2;79(1):30-42.e4
pubmed: 32473093
Cell. 2013 Jul 18;154(2):365-76
pubmed: 23870125
Mol Metab. 2019 Sep;27S:S92-S103
pubmed: 31500836
Cell Death Differ. 2020 Mar;27(3):872-886
pubmed: 31896796
Eur J Cell Biol. 2017 Mar;96(2):83-98
pubmed: 28110910
J Biol Chem. 2015 Oct 23;290(43):25907-19
pubmed: 26370078
Cancer Cell. 2016 Jul 11;30(1):147-160
pubmed: 27411589
Cancer Discov. 2014 Aug;4(8):914-27
pubmed: 24875857
PLoS Pathog. 2013 Aug;9(8):e1003562
pubmed: 23966861
J Cell Biol. 2018 Oct 1;217(10):3354-3367
pubmed: 30143524
Nat Cell Biol. 2015 Jan;17(1):20-30
pubmed: 25438055
Annu Rev Physiol. 2018 Feb 10;80:1-26
pubmed: 29068766
Nat Immunol. 2017 Mar;18(3):293-302
pubmed: 28092373
J Gastroenterol. 2012 Apr;47(4):433-43
pubmed: 22124574
Nature. 2021 Mar;591(7848):117-123
pubmed: 33442062
Int Rev Cell Mol Biol. 2019;348:217-262
pubmed: 31810554
Cell Death Dis. 2010;1:e10
pubmed: 21364612
EMBO J. 2015 Apr 1;34(7):856-80
pubmed: 25712477
Annu Rev Cell Dev Biol. 2020 Oct 6;36:165-189
pubmed: 33021824
Nat Rev Mol Cell Biol. 2018 Sep;19(9):579-593
pubmed: 30006559
Sci Rep. 2017 Jun 14;7(1):3552
pubmed: 28615637
Science. 2010 Dec 3;330(6009):1344-8
pubmed: 21127245
Cell Metab. 2009 Dec;10(6):507-15
pubmed: 19945408
Autophagy. 2018;14(2):190-198
pubmed: 28813180
Autophagy. 2012 May 1;8(5):826-37
pubmed: 22617445
J Hepatol. 2016 Jan;64(1):118-27
pubmed: 26325539
Cell Rep. 2012 Jul 26;2(1):136-49
pubmed: 22840404
J Cell Biol. 2005 May 9;169(3):425-34
pubmed: 15866887
J Neurochem. 2019 Mar;148(5):573-589
pubmed: 30092616
J Cell Biol. 2018 Oct 1;217(10):3640-3655
pubmed: 30018090
Neurosci Lett. 2019 Sep 25;710:132933
pubmed: 28669745
J Cell Biol. 2010 Apr 19;189(2):211-21
pubmed: 20404107
EMBO J. 2021 May 17;40(10):e103563
pubmed: 33932238
Nat Commun. 2019 Jul 17;10(1):3145
pubmed: 31316058
Cell Death Discov. 2018 Jul 17;4:14
pubmed: 30210817
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Cell. 2011 Sep 2;146(5):682-95
pubmed: 21884931
PLoS One. 2012;7(7):e41394
pubmed: 22815997
Mol Syst Biol. 2011 Sep 27;7:533
pubmed: 21952136
Annu Rev Physiol. 2020 Feb 10;82:297-322
pubmed: 31640469
Biochem Biophys Res Commun. 2014 Apr 18;446(4):1190-6
pubmed: 24680677
J Biol Chem. 2013 Apr 19;288(16):11436-47
pubmed: 23479732
Autophagy. 2014;10(11):2036-52
pubmed: 25483966
J Cell Sci. 2020 May 27;133(10):
pubmed: 32461337
Diabetologia. 2012 Feb;55(2):392-403
pubmed: 22075916
Cell Death Differ. 2017 Jul;24(7):1205-1213
pubmed: 26160071
J Hepatol. 2020 Mar;72(3):528-538
pubmed: 31726115
Science. 2011 Dec 16;334(6062):1573-7
pubmed: 22174255
Cell Host Microbe. 2012 Mar 15;11(3):298-305
pubmed: 22423969
PLoS One. 2015 Sep 18;10(9):e0138625
pubmed: 26382847
Autophagy. 2012 May 1;8(5):719-30
pubmed: 22647656
Genes Dev. 2019 Jun 1;33(11-12):610-619
pubmed: 31160394
Cell Death Dis. 2018 Jan 24;9(2):105
pubmed: 29367621
Cell Death Differ. 2014 Jan;21(1):79-91
pubmed: 23852373
Genes Dev. 2016 Sep 1;30(17):1913-30
pubmed: 27664235
J Neurosci. 2008 Jul 2;28(27):6926-37
pubmed: 18596167
Brain. 2014 Mar;137(Pt 3):683-92
pubmed: 24459106
Nat Commun. 2014 May 13;5:3828
pubmed: 24819384
Int Rev Cell Mol Biol. 2017;328:1-23
pubmed: 28069131
Cell Death Differ. 2015 Mar;22(3):476-87
pubmed: 25501597
Biol Reprod. 2012 Mar 19;86(3):70
pubmed: 22088918
Nat Biotechnol. 2010 Mar;28(3):256-63
pubmed: 20190739
Mol Cell. 2014 Apr 24;54(2):224-33
pubmed: 24766886
Nat Commun. 2019 Apr 5;10(1):1566
pubmed: 30952952
Neuron. 2015 Jul 15;87(2):371-81
pubmed: 26182419
Autophagy. 2021 Sep;17(9):2629-2638
pubmed: 32954947
Autophagy. 2016 Jun 2;12(6):976-98
pubmed: 27123926
Nature. 2018 Sep;561(7722):258-262
pubmed: 30135585
Nature. 2004 Dec 23;432(7020):1032-6
pubmed: 15525940
J Clin Invest. 2003 Dec;112(12):1809-20
pubmed: 14638851
Nat Cell Biol. 2015 Mar;17(3):262-75
pubmed: 25686248
Autophagy. 2017 Jul 3;13(7):1191-1204
pubmed: 28581888
Cell Death Differ. 2021 Apr;28(4):1317-1332
pubmed: 33159184
Cell. 2019 Jul 25;178(3):536-551.e14
pubmed: 31257024
Immunity. 2021 Mar 9;54(3):437-453
pubmed: 33691134
J Neuropathol Exp Neurol. 2005 Feb;64(2):113-22
pubmed: 15751225
J Biol Chem. 2013 Apr 12;288(15):10703-14
pubmed: 23457305
Hum Mol Genet. 2008 Dec 1;17(23):3708-19
pubmed: 18765443
Front Cell Infect Microbiol. 2020 Sep 15;10:474
pubmed: 33042861
Nat Microbiol. 2018 Dec;3(12):1472-1485
pubmed: 30478389
J Cell Physiol. 2019 Apr;234(4):5023-5032
pubmed: 30203495
Nature. 2014 Dec 4;516(7529):94-8
pubmed: 25409145
Genes Dev. 2009 Oct 1;23(19):2294-306
pubmed: 19762508
Nature. 2017 Jan 19;541(7637):417-420
pubmed: 28077876
Cell Cycle. 2019 Jul;18(13):1435-1445
pubmed: 31135269
J Clin Invest. 2014 Aug;124(8):3634-44
pubmed: 25036706
Nature. 2018 Nov;563(7732):569-573
pubmed: 30429607
Hepatology. 2018 Jun;67(6):2397-2413
pubmed: 29272037
Nat Commun. 2021 May 5;12(1):2550
pubmed: 33953176
J Neurosci. 2014 Jan 22;34(4):1293-305
pubmed: 24453320
Autophagy. 2015;11(12):2142-52
pubmed: 26565691
J Biol Chem. 2013 Jan 11;288(2):915-26
pubmed: 23152496
Int Rev Cell Mol Biol. 2020;352:159-187
pubmed: 32334815
Nature. 2013 Sep 26;501(7468):512-6
pubmed: 24005326
Autophagy. 2017;13(12):2028-2040
pubmed: 28980867
J Clin Invest. 2015 Feb;125(2):521-38
pubmed: 25562319
Circ Res. 2007 Mar 30;100(6):914-22
pubmed: 17332429
Cell Metab. 2018 Feb 6;27(2):439-449.e5
pubmed: 29337137
Trends Endocrinol Metab. 2020 Jan;31(1):53-66
pubmed: 31699565
Nat Commun. 2020 Jun 26;11(1):3258
pubmed: 32591533
Kidney Int. 2010 Oct;78(8):754-61
pubmed: 20686448
Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17345-50
pubmed: 20855599
Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):391-396
pubmed: 29279371
J Biol Chem. 2006 Feb 17;281(7):4467-76
pubmed: 16365039
Cell. 2014 Nov 6;159(4):709-13
pubmed: 25417146
EMBO J. 2016 Sep 15;35(18):1991-2007
pubmed: 27511903
J Cell Biol. 2007 Nov 5;179(3):485-500
pubmed: 17984323
Hum Mol Genet. 2013 Sep 1;22(17):3559-67
pubmed: 23669351
Nat Med. 2015 Dec;21(12):1406-15
pubmed: 26646497
Nat Rev Endocrinol. 2018 Jun;14(6):356-376
pubmed: 29686432
Nat Genet. 2013 Apr;45(4):445-9, 449e1
pubmed: 23435086
Mol Neurobiol. 2020 Feb;57(2):685-697
pubmed: 31446549
Nat Rev Mol Cell Biol. 2020 Apr;21(4):204-224
pubmed: 32071438
Int Rev Cell Mol Biol. 2020;354:165-186
pubmed: 32475472
Autophagy. 2016 Sep;12(9):1575-92
pubmed: 27310465
J Exp Med. 2015 Jun 29;212(7):979-90
pubmed: 26101267
Cell Host Microbe. 2015 Apr 8;17(4):429-40
pubmed: 25816775
Curr Biol. 2018 Jan 22;28(2):287-295.e6
pubmed: 29307555
EMBO J. 2017 Jul 3;36(13):1811-1836
pubmed: 28596378
Autophagy. 2015;11(3):472-86
pubmed: 25719862
Clin Genet. 2020 Apr;97(4):586-594
pubmed: 32020600
Autophagy. 2021 Oct;17(10):2766-2782
pubmed: 33143524
Nat Commun. 2019 Feb 19;10(1):847
pubmed: 30783089
Int Rev Cell Mol Biol. 2020;352:189-214
pubmed: 32334816
J Cell Biol. 2010 Aug 23;190(4):533-9
pubmed: 20713600
Autophagy. 2017;13(11):2002-2003
pubmed: 28806138
Cells. 2019 May 22;8(5):
pubmed: 31121959
Autophagy. 2015;11(6):881-90
pubmed: 26000824
Nat Commun. 2020 Jan 16;11(1):307
pubmed: 31949142
Gastroenterology. 2012 Mar;142(3):644-653.e3
pubmed: 22155365
Cell. 2014 Dec 4;159(6):1263-76
pubmed: 25480292
Clin Chim Acta. 2020 Mar;502:139-147
pubmed: 31877297
Nat Cell Biol. 2015 Jul;17(7):893-906
pubmed: 26098576
Autophagy. 2014 Mar;10(3):480-96
pubmed: 24468901
Nat Commun. 2020 Mar 13;11(1):1386
pubmed: 32170061
EMBO J. 2016 Aug 1;35(15):1656-76
pubmed: 27334615
J Hepatol. 2019 May;70(5):985-998
pubmed: 30711404
Gastroenterology. 2016 Feb;150(2):328-39
pubmed: 26453774
Nat Metab. 2020 Jan;2(1):110-125
pubmed: 32128508
Nat Genet. 2001 Nov;29(3):326-31
pubmed: 11685207
Mol Cell. 2019 Feb 7;73(3):429-445.e7
pubmed: 30612879
Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364
pubmed: 29618831
Int Rev Cell Mol Biol. 2019;348:179-215
pubmed: 31810553
J Biol Chem. 2013 Jun 14;288(24):17432-40
pubmed: 23645674
Mol Neurodegener. 2016 Dec 9;11(1):76
pubmed: 27938392
Autophagy. 2019 Sep;15(9):1558-1571
pubmed: 30821613
Nat Commun. 2018 May 22;9(1):1944
pubmed: 29789598
EMBO Rep. 2012 Mar 01;13(3):258-65
pubmed: 22249165
Gut. 2019 Mar;68(3):522-532
pubmed: 30301768
Cell Microbiol. 2019 Dec;21(12):e13095
pubmed: 31392811
Cell. 2016 Oct 20;167(3):606-609
pubmed: 27768885
Nat Cell Biol. 2013 Jun;15(6):647-58
pubmed: 23604321
Gastroenterology. 2012 Apr;142(4):938-46
pubmed: 22240484
Cell Stress. 2019 Apr 29;3(5):141-161
pubmed: 31225510
Biochem Biophys Res Commun. 2010 Jul 16;398(1):26-31
pubmed: 20540933
Science. 2019 Mar 29;363(6434):
pubmed: 30923193
Am J Pathol. 2010 Aug;177(2):632-43
pubmed: 20616344
Autophagy. 2021 Sep;17(9):2217-2237
pubmed: 32960680
Autophagy. 2010 Oct;6(7):922-8
pubmed: 20818164
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8675-E8684
pubmed: 28973855
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5091-6
pubmed: 23479643
Int Rev Cell Mol Biol. 2019;342:149-173
pubmed: 30635090
N Engl J Med. 2020 Oct 15;383(16):1564-1576
pubmed: 33053285
J Cell Biol. 2010 Sep 20;190(6):1023-37
pubmed: 20855506
Sci Signal. 2018 Apr 24;11(527):
pubmed: 29692364
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17396-401
pubmed: 21969579
eNeuro. 2018 Jan 10;5(6):
pubmed: 30783609
Nature. 2021 Apr;592(7855):634-638
pubmed: 33854238
Autophagy. 2009 Feb;5(2):250-2
pubmed: 19139628
Cell Death Dis. 2013 Oct 03;4:e826
pubmed: 24091669
Trends Cell Biol. 2017 May;27(5):340-351
pubmed: 28011061
Cell Metab. 2012 Apr 4;15(4):534-44
pubmed: 22440612
Int J Biochem Cell Biol. 2010 Dec;42(12):1973-83
pubmed: 20797447
Cell Death Dis. 2018 Aug 29;9(9):879
pubmed: 30158533
Autophagy. 2012 Nov;8(11):1643-56
pubmed: 22874552
Sci Adv. 2020 Aug 14;6(33):eabb9036
pubmed: 32851186
J Physiol Biochem. 2020 May;76(2):213-226
pubmed: 31811543
Nat Commun. 2019 Apr 5;10(1):1567
pubmed: 30952864
Cell Metab. 2017 May 2;25(5):1037-1043
pubmed: 28467923
Autophagy. 2018;14(7):1256-1266
pubmed: 29999454
Int Rev Cell Mol Biol. 2020;354:63-105
pubmed: 32475477
Cancer Discov. 2013 Aug;3(8):894-907
pubmed: 23650262
Am J Pathol. 2010 Sep;177(3):1377-87
pubmed: 20616343
Nat Commun. 2018 Feb 28;9(1):873
pubmed: 29491374
Cell. 2021 May 13;184(10):2696-2714.e25
pubmed: 33891876
Nat Rev Neurosci. 2016 Aug;17(8):467-84
pubmed: 27256553
Nat Immunol. 2014 Nov;15(11):1046-54
pubmed: 25263126
Nat Neurosci. 2019 Mar;22(3):401-412
pubmed: 30742114
J Mol Med (Berl). 2014 Feb;92(2):127-37
pubmed: 24271008
J Exp Med. 2018 Nov 5;215(11):2868-2886
pubmed: 30254094
Cell Metab. 2019 Apr 2;29(4):803-826
pubmed: 30943392
Cell. 2016 May 5;165(4):867-81
pubmed: 27133164
J Neurosci. 2011 Feb 9;31(6):2125-35
pubmed: 21307249
Autophagy. 2013 Aug;9(8):1253-5
pubmed: 23811580
Autophagy. 2019 Apr;15(4):583-598
pubmed: 30290707
Int J Cell Biol. 2012;2012:282041
pubmed: 22536247
Development. 2018 Feb 26;145(4):
pubmed: 29483129
Bone Res. 2019 Oct 3;7:28
pubmed: 31666998
Arthritis Rheum. 2010 Mar;62(3):791-801
pubmed: 20187128
EMBO J. 2019 Jan 15;38(2):
pubmed: 30498130
Science. 2006 Sep 8;313(5792):1438-41
pubmed: 16888103
Nature. 2016 May 5;533(7601):115-9
pubmed: 27096368
Nature. 2021 Jan;589(7842):456-461
pubmed: 33328639
Nature. 2010 Jul 1;466(7302):68-76
pubmed: 20562859
Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):
pubmed: 33531365
Am J Hum Genet. 2012 Dec 7;91(6):1065-72
pubmed: 23176824
Immunity. 2013 Aug 22;39(2):211-27
pubmed: 23973220
Nat Cell Biol. 2018 May;20(5):521-527
pubmed: 29686264
J Neurochem. 2011 Jan;116(2):248-59
pubmed: 21062285
Cell. 2021 Jan 7;184(1):33-63
pubmed: 33340459
Nat Rev Immunol. 2017 Feb;17(2):97-111
pubmed: 27748397
Science. 2016 May 27;352(6289):1116-20
pubmed: 27230380
Autophagy. 2017 May 4;13(5):928-940
pubmed: 28410006
Autophagy. 2014 Jul;10(7):1256-71
pubmed: 24905722
Autophagy. 2015;11(6):939-53
pubmed: 26075877
J Am Soc Nephrol. 2016 Jun;27(6):1609-16
pubmed: 26487561
Nat Genet. 2006 Oct;38(10):1184-91
pubmed: 16964263
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11364-9
pubmed: 18687901
J Neurochem. 2008 Jul;106(1):107-20
pubmed: 18346206
Sci Adv. 2019 May 08;5(5):eaau8857
pubmed: 31123703
Oncoimmunology. 2020 Jul 8;9(1):1789284
pubmed: 32923151
Nat Rev Mol Cell Biol. 2016 Oct;17(10):607
pubmed: 27625322
Trends Neurosci. 2020 Oct;43(10):767-779
pubmed: 32800535
Eur J Immunol. 2019 Apr;49(4):523-533
pubmed: 30776086
Cell. 2011 Nov 11;147(4):728-41
pubmed: 22078875
Cardiovasc Res. 2020 Mar 1;116(3):483-504
pubmed: 31504266
Neuron. 2020 Jun 3;106(5):789-805.e5
pubmed: 32220666
Int Rev Cell Mol Biol. 2020;350:285-325
pubmed: 32138902
Cell Host Microbe. 2018 Dec 12;24(6):866-874.e4
pubmed: 30543779
Exp Eye Res. 2016 Mar;144:81-9
pubmed: 26315785
Oncoimmunology. 2020 Sep 13;9(1):1818438
pubmed: 33457099
Nature. 2017 Jan 19;541(7637):412-416
pubmed: 28077878
PLoS Genet. 2010 Feb 05;6(2):e1000838
pubmed: 20140187
Int Rev Cell Mol Biol. 2018;337:153-184
pubmed: 29551160
Neuron. 2013 Apr 10;78(1):65-80
pubmed: 23498974
Nat Med. 2019 Apr;25(4):620-627
pubmed: 30833748
PLoS One. 2014 Jun 12;9(6):e99719
pubmed: 24923557
Arthritis Rheum. 2012 Jun;64(6):1920-8
pubmed: 22147463
Nature. 2013 Feb 14;494(7436):201-6
pubmed: 23364696
Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3349-58
pubmed: 27247382
Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E705-14
pubmed: 22331875
Nat Chem Biol. 2013 Jun;9(6):374-82
pubmed: 23584676
Autophagy. 2015;11(7):1010-24
pubmed: 26120731
J Biol Chem. 2013 Mar 15;288(11):7506-7518
pubmed: 23341467
Neurobiol Dis. 2019 Feb;122:23-34
pubmed: 30030024
Mol Cell. 2015 Oct 1;60(1):89-104
pubmed: 26431026
Stem Cell Reports. 2020 Mar 10;14(3):420-432
pubmed: 32059792
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4439-48
pubmed: 25294927
Cell. 2019 Jun 13;177(7):1682-1699
pubmed: 31199916
Curr Opin Cell Biol. 2015 Aug;35:106-16
pubmed: 25988755
Cell Death Dis. 2014 Aug 07;5:e1363
pubmed: 25101676
J Exp Med. 2017 Dec 4;214(12):3687-3705
pubmed: 29089374
J Cell Sci. 2019 Feb 20;132(5):
pubmed: 30787029
J Biol Chem. 2004 Apr 30;279(18):18614-22
pubmed: 14985362
Sci Transl Med. 2020 Apr 15;12(539):
pubmed: 32295902
J Cardiovasc Transl Res. 2010 Aug;3(4):374-83
pubmed: 20559783
Nat Commun. 2020 Oct 20;11(1):5311
pubmed: 33082312
Nature. 2006 Jun 15;441(7095):880-4
pubmed: 16625205
Annu Rev Immunol. 2013;31:51-72
pubmed: 23157435
J Neurochem. 2008 May;105(3):1048-56
pubmed: 18182054
Nat Rev Rheumatol. 2021 Jan;17(1):47-57
pubmed: 33208917
Nat Rev Immunol. 2015 Jul;15(7):405-14
pubmed: 26027717
Cell Metab. 2015 Jun 2;21(6):805-21
pubmed: 26039447
J Am Soc Nephrol. 2016 Sep;27(9):2685-700
pubmed: 26823550
Gastroenterology. 2019 Mar;156(4):1173-1189.e5
pubmed: 30452922
J Biol Chem. 2006 Apr 21;281(16):11374-83
pubmed: 16495224
Nature. 2014 May 15;509(7500):366-70
pubmed: 24739961
Oncoimmunology. 2019 Sep 7;8(11):e1657375
pubmed: 31646107
JCI Insight. 2021 Mar 8;6(5):
pubmed: 33539326
J Cell Biol. 2005 Oct 10;171(1):87-98
pubmed: 16203860
Genes Dev. 2007 Dec 1;21(23):3061-6
pubmed: 18056421
Circ Res. 2009 Feb 13;104(3):304-17
pubmed: 19213965
Nat Med. 2013 Mar;19(3):351-7
pubmed: 23435171
Cell. 2017 Aug 10;170(4):649-663.e13
pubmed: 28802038
Cell Stem Cell. 2009 Nov 6;5(5):540-53
pubmed: 19896444
J Clin Invest. 2013 Dec;123(12):5284-97
pubmed: 24177425
Nature. 2012 May 10;485(7397):251-5
pubmed: 22535248
Neuron. 2010 Dec 9;68(5):857-64
pubmed: 21145000
Cell Metab. 2018 Apr 3;27(4):886-897.e4
pubmed: 29617646
J Cell Biol. 2013 Mar 18;200(6):731-41
pubmed: 23479740
Cell Death Dis. 2019 Feb 12;10(2):127
pubmed: 30755584
Immunity. 2012 Aug 24;37(2):223-34
pubmed: 22921120
Autophagy. 2021 Oct;17(10):3096-3108
pubmed: 33213269
Science. 2011 Jul 8;333(6039):228-33
pubmed: 21617041
Autophagy. 2018;14(8):1419-1434
pubmed: 29916295
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3462-E3471
pubmed: 28389568
J Hepatol. 2020 Oct;73(4):970-972
pubmed: 32684364
Dev Cell. 2011 Jan 18;20(1):131-9
pubmed: 21238931
Nat Cell Biol. 2010 Sep;12(9):823-30
pubmed: 20811354
J Clin Invest. 2010 Apr;120(4):1084-96
pubmed: 20200449
Nat Microbiol. 2017 May 08;2:17063
pubmed: 28481331
Cell Death Dis. 2017 Aug 3;8(8):e2970
pubmed: 28771229
Nat Med. 2013 Aug;19(8):983-97
pubmed: 23921753
Immunity. 2012 Dec 14;37(6):986-997
pubmed: 23219390
Science. 2011 May 20;332(6032):966-70
pubmed: 21512002
J Virol. 2019 Jul 17;93(15):
pubmed: 31118257
Dev Cell. 2019 Sep 23;50(6):690-703.e6
pubmed: 31378590
Autophagy. 2018;14(2):221-232
pubmed: 29130366
Immunity. 2010 Feb 26;32(2):227-39
pubmed: 20171125
EMBO Rep. 2015 Sep;16(9):1145-63
pubmed: 26232272
J Clin Invest. 2020 Jun 1;130(6):2978-2991
pubmed: 32364533
J Clin Invest. 2009 Nov;119(11):3329-39
pubmed: 19855132
Cell Metab. 2008 Oct;8(4):325-32
pubmed: 18840363
Oncoimmunology. 2020 Aug 23;9(1):1800162
pubmed: 32923161
Genes Dev. 2011 Apr 15;25(8):795-800
pubmed: 21498569
Nature. 2008 Jan 17;451(7176):350-4
pubmed: 18202661
J Cell Physiol. 2016 Jul;231(7):1450-9
pubmed: 26580995
Nature. 2006 Jun 15;441(7095):885-9
pubmed: 16625204
Inflamm Res. 2013 Feb;62(2):229-37
pubmed: 23178792
Nat Rev Mol Cell Biol. 2018 Jun;19(6):365-381
pubmed: 29626215
Nature. 2000 Aug 24;406(6798):906-10
pubmed: 10972294
Genes Dev. 2013 Jul 1;27(13):1447-61
pubmed: 23824538
Eur J Immunol. 2016 Dec;46(12):2862-2870
pubmed: 27624289
Nature. 2015 Dec 24;528(7583):565-9
pubmed: 26649827
Nature. 2012 Jan 15;482(7385):414-8
pubmed: 22246324
Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):31
pubmed: 32797200
PLoS One. 2014 Apr 21;9(4):e95758
pubmed: 24752605
Cell Host Microbe. 2012 Dec 13;12(6):778-90
pubmed: 23245322
Nat Commun. 2019 Dec 18;10(1):5770
pubmed: 31852899
J Immunol. 2015 Jun 1;194(11):5407-16
pubmed: 25888640
J Hepatol. 2020 Jan;72(1):183-196
pubmed: 31849347
Curr Osteoporos Rep. 2018 Aug;16(4):466-477
pubmed: 29934753
JCI Insight. 2017 Dec 21;2(24):
pubmed: 29263299
Nat Neurosci. 2020 May;23(5):615-624
pubmed: 32284607
Dev Cell. 2011 Nov 15;21(5):966-74
pubmed: 22055344
Autophagy. 2017;13(12):2163-2170
pubmed: 28598229
Nature. 2009 Apr 30;458(7242):1131-5
pubmed: 19339967
Elife. 2017 Apr 11;6:
pubmed: 28395732
Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30488-30497
pubmed: 33199631
Front Neurosci. 2020 Mar 18;14:227
pubmed: 32256311
J Mol Biol. 2020 Apr 3;432(8):2483-2509
pubmed: 31654670
J Cell Biol. 2008 Dec 1;183(5):795-803
pubmed: 19029340
Hum Mol Genet. 2006 Feb 1;15(3):433-42
pubmed: 16368705
Genes Dev. 2009 Apr 1;23(7):798-803
pubmed: 19279323
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18880-5
pubmed: 20956295
Oncoimmunology. 2019 Apr 13;8(7):1596004
pubmed: 31143517
Ann Neurol. 2018 Jun;83(6):1089-1095
pubmed: 29518281
Nature. 2016 Jan 7;529(7584):37-42
pubmed: 26738589
Future Neurol. 2008 May;3(3):309-323
pubmed: 18806889
Neuron. 2021 Jan 20;109(2):299-313.e9
pubmed: 33157003
Gastroenterology. 2010 Nov;139(5):1740-52
pubmed: 20659474
Genes Dev. 2011 Jul 15;25(14):1510-27
pubmed: 21764854
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1829-34
pubmed: 17267617
Hepatology. 2016 Dec;64(6):1994-2014
pubmed: 27637015
FASEB J. 2015 Jul;29(7):2912-29
pubmed: 25792665
Immunity. 2013 Apr 18;38(4):729-41
pubmed: 23562161
Hepatology. 2012 Jan;55(1):222-32
pubmed: 21932416
Int Rev Cell Mol Biol. 2020;353:153-209
pubmed: 32381175
Neuron. 2015 Nov 18;88(4):735-48
pubmed: 26590345
Cell. 2004 Dec 17;119(6):753-66
pubmed: 15607973
Hum Mol Genet. 2010 Sep 1;19(17):3440-56
pubmed: 20570967
Nature. 2015 Dec 10;528(7581):272-5
pubmed: 26595272
Cell Rep. 2018 Jun 12;23(11):3286-3299
pubmed: 29898399
Curr Opin Clin Nutr Metab Care. 2014 Jul;17(4):329-37
pubmed: 24848530
Nature. 2017 May 4;545(7652):108-111
pubmed: 28445460
J Clin Invest. 2008 Feb;118(2):777-88
pubmed: 18172548
Reproduction. 2016 Aug;152(2):151-60
pubmed: 27190213
Nat Commun. 2021 Apr 14;12(1):2238
pubmed: 33854069
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16889-94
pubmed: 25385587
Nat Genet. 2009 Nov;41(11):1179-81
pubmed: 19838196
Mol Cell Biol. 2013 Jan;33(1):98-110
pubmed: 23109424
Nat Rev Cancer. 2021 May;21(5):281-297
pubmed: 33758415
Toxicol Sci. 2012 Jun;127(2):438-50
pubmed: 22491424
Cell Death Differ. 2020 Mar;27(3):903-918
pubmed: 31988494
Cell Death Differ. 2021 Apr;28(4):1437-1439
pubmed: 33664481
Nature. 2020 Feb;578(7796):605-609
pubmed: 32051584
Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19860-5
pubmed: 19910529
Cell Rep. 2021 Apr 13;35(2):108985
pubmed: 33852843
J Clin Invest. 2020 Apr 1;130(4):2111-2128
pubmed: 31961824
Mol Cell. 2020 Dec 3;80(5):779-795.e10
pubmed: 33207181
Nat Cell Biol. 2018 Sep;20(9):1013-1022
pubmed: 30154567
J Neurochem. 2009 Jul;110(2):613-21
pubmed: 19457102
Cell Metab. 2012 Feb 8;15(2):247-55
pubmed: 22285542
Hum Mol Genet. 2017 Jan 1;26(1):158-172
pubmed: 28007903
Trends Biochem Sci. 2021 Jul;46(7):608-620
pubmed: 33526371
Science. 2021 Jan 29;371(6528):
pubmed: 33303683
Cell Host Microbe. 2018 Feb 14;23(2):191-202.e4
pubmed: 29358084
Nat Rev Mol Cell Biol. 2018 Nov;19(11):731-745
pubmed: 30305710
Circ Res. 2011 Aug 19;109(5):502-11
pubmed: 21737790
Cell Death Dis. 2019 Mar 15;10(4):258
pubmed: 30874543
Nat Rev Microbiol. 2018 Jun;16(6):341-354
pubmed: 29556036
J Clin Invest. 2015 Jan;125(1):42-6
pubmed: 25654549
Transl Stroke Res. 2011 Mar 1;2(1):42-50
pubmed: 21720543
Autophagy. 2013 Sep;9(9):1321-33
pubmed: 23800795
Cell. 2012 Aug 17;150(4):803-15
pubmed: 22901810
Ann Hum Genet. 2003 Sep;67(Pt 5):471-85
pubmed: 12940920
Mol Cell. 2015 Jul 16;59(2):285-97
pubmed: 26118643
Adv Drug Deliv Rev. 2021 Feb;169:40-50
pubmed: 33301821
Front Cell Infect Microbiol. 2017 Apr 24;7:112
pubmed: 28484683
Circ Res. 2015 Apr 10;116(8):1477-90
pubmed: 25858070
Nature. 2010 Apr 29;464(7293):1357-61
pubmed: 20428172
EMBO J. 2021 Mar 15;40(6):e105543
pubmed: 33586810
Int J Oncol. 2016 Dec;49(6):2367-2376
pubmed: 27840904
Cell Death Differ. 2020 Jan;27(1):71-84
pubmed: 31076632
Front Immunol. 2021 Mar 18;12:662987
pubmed: 33815423
Nat Rev Immunol. 2019 Mar;19(3):170-183
pubmed: 30531943
Autophagy. 2021 Sep;17(9):2511-2527
pubmed: 33030400
Antioxidants (Basel). 2021 Jan 12;10(1):
pubmed: 33445755
FASEB J. 2019 Mar;33(3):4571-4585
pubmed: 30571313
Science. 2015 Dec 4;350(6265):aad2459
pubmed: 26785495
Autophagy. 2009 Nov;5(8):1118-30
pubmed: 19844159
Clin Genet. 2018 Feb;93(2):360-364
pubmed: 28503735
Stem Cells Int. 2018 Jan 21;2018:9131397
pubmed: 29765428
Cell Metab. 2011 Aug 3;14(2):173-83
pubmed: 21803288
J Neurosci. 2017 Nov 15;37(46):11151-11165
pubmed: 29038245
EMBO J. 2016 Aug 1;35(15):1677-93
pubmed: 27334614
Cancer Discov. 2018 Mar;8(3):276-287
pubmed: 29317452
PLoS Genet. 2015 Feb 27;11(2):e1004987
pubmed: 25723488
Cell. 2010 Jun 25;141(7):1135-45
pubmed: 20602997
Nat Rev Immunol. 2016 Nov;16(11):661-675
pubmed: 27694913
EMBO J. 2015 Apr 15;34(8):1025-41
pubmed: 25586377
Cell Host Microbe. 2007 Mar 15;1(1):23-35
pubmed: 18005679
Cell Metab. 2017 Jun 6;25(6):1374-1389.e6
pubmed: 28552492
Mol Cell. 2015 Aug 20;59(4):522-39
pubmed: 26295960
Mol Cell Oncol. 2014 Jul 15;1(1):e29911
pubmed: 27308318
Aging Cell. 2015 Apr;14(2):249-64
pubmed: 25620427
Neuron. 2020 May 20;106(4):700
pubmed: 32437656
J Am Soc Nephrol. 2014 Feb;25(2):305-15
pubmed: 24179166
Sci Transl Med. 2013 Sep 11;5(202):202ra123
pubmed: 24027027
Cell Death Dis. 2013 Oct 17;4:e860
pubmed: 24136224
Prog Neurobiol. 2012 May;97(2):67-82
pubmed: 21930185
J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:10-4
pubmed: 22320909
J Cell Physiol. 2012 Feb;227(2):639-48
pubmed: 21465467
Cell Metab. 2008 Oct;8(4):318-24
pubmed: 18840362
PLoS One. 2011;6(9):e25268
pubmed: 21966475
Cell Death Differ. 2016 Aug;23(8):1380-93
pubmed: 27035618
Cell Rep. 2019 Apr 9;27(2):502-513.e5
pubmed: 30970253
Nat Commun. 2012;3:1078
pubmed: 23011132
J Biol Chem. 2008 Nov 28;283(48):33175-82
pubmed: 18772134
Cell Mol Life Sci. 2019 Apr;76(7):1433-1445
pubmed: 30666337
Nature. 2013 Dec 12;504(7479):296-300
pubmed: 24305049
Oncotarget. 2017 Aug 18;8(43):74720-74735
pubmed: 29088819
PLoS Pathog. 2009 Oct;5(10):e1000609
pubmed: 19816569
J Am Soc Nephrol. 2014 Dec;25(12):2835-46
pubmed: 24854279
Nat Commun. 2020 Jan 13;11(1):189
pubmed: 31929511
Int Rev Cell Mol Biol. 2020;350:63-118
pubmed: 32138904
Cancer Cell. 2021 Mar 8;39(3):310-345
pubmed: 33338426
Cell Death Differ. 2014 Jan;21(1):92-9
pubmed: 24037090
Hum Mol Genet. 2015 Jul 1;24(13):3623-37
pubmed: 25794683
Nat Cell Biol. 2018 Mar;20(3):243-251
pubmed: 29476153
Circulation. 2012 Mar 6;125(9):1134-46
pubmed: 22294621
Autophagy. 2013 Jun 1;9(6):830-49
pubmed: 23486312
J Neurol Neurosurg Psychiatry. 2012 Jan;83(1):119-20
pubmed: 21115472
EMBO Mol Med. 2013 Mar;5(3):397-412
pubmed: 23381957
Annu Rev Cell Dev Biol. 2019 Oct 6;35:453-475
pubmed: 31283377
J Bone Miner Res. 2013 Nov;28(11):2414-30
pubmed: 23633228
Cancer Treat Rev. 2020 Aug;88:102043
pubmed: 32505806
Int Rev Cell Mol Biol. 2018;340:169-208
pubmed: 30072091
Autophagy. 2016 May 3;12(5):864-75
pubmed: 26979828
PLoS One. 2016 Mar 29;11(3):e0152628
pubmed: 27023784
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2174-9
pubmed: 15684050
Autophagy. 2017 Oct 3;13(10):1619-1628
pubmed: 28820286
J Neuromuscul Dis. 2016 May 27;3(2):127-155
pubmed: 27854220
Cell Death Differ. 2021 Mar;28(3):884-899
pubmed: 33473181
Nat Cell Biol. 2015 Aug;17(8):1062-73
pubmed: 26214133
Nat Rev Clin Oncol. 2017 Apr;14(4):247-258
pubmed: 27845767
J Am Soc Nephrol. 2013 Apr;24(5):727-43
pubmed: 23492732
Autophagy. 2018;14(10):1726-1741
pubmed: 29962255
Elife. 2016 Feb 24;5:e12444
pubmed: 26910010
Cancer Microenviron. 2013 Aug;6(2):147-57
pubmed: 23104434
Prog Retin Eye Res. 2016 Nov;55:206-245
pubmed: 27566190
Nat Med. 2013 Nov;19(11):1478-88
pubmed: 24141421
Gastroenterology. 2018 Sep;155(3):865-879.e12
pubmed: 29782848
Am J Pathol. 2008 Feb;172(2):454-69
pubmed: 18187572
Aging (Albany NY). 2009 Dec 23;1(12):961-70
pubmed: 20157579
Cell Metab. 2010 Jun 9;11(6):467-78
pubmed: 20519119
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9572-7
pubmed: 21606348
Protein Cell. 2014 Dec;5(12):912-27
pubmed: 25311841
Cell Death Dis. 2016 May 26;7:e2238
pubmed: 27228353
Nat Cell Biol. 2020 Aug;22(8):973-985
pubmed: 32753672
J Clin Invest. 2014 Sep;124(9):3987-4003
pubmed: 25083992
Autophagy. 2021 Jan;17(1):1-382
pubmed: 33634751
J Pathol. 2019 Apr;247(5):708-718
pubmed: 30570140
Ann Rheum Dis. 2015 May;74(5):912-20
pubmed: 24419333
EMBO J. 2021 Oct 1;40(19):e108863
pubmed: 34459017
Kidney Int. 2016 Apr;89(4):779-91
pubmed: 26924060
Nature. 2014 Feb 27;506(7489):456-62
pubmed: 24553140
Cell. 2018 Jun 28;174(1):88-101.e16
pubmed: 29909986
Nat Commun. 2019 Jul 31;10(1):3436
pubmed: 31366886
Int Rev Cell Mol Biol. 2019;348:123-178
pubmed: 31810552
Nature. 1998 Apr 9;392(6676):605-8
pubmed: 9560156
Cell Metab. 2012 Apr 4;15(4):545-53
pubmed: 22445600
Dev Cell. 2020 Mar 9;52(5):591-604.e6
pubmed: 32084360
Cell. 2016 Aug 11;166(4):802-821
pubmed: 27518560
Curr Biol. 2019 Feb 4;29(3):435-448.e8
pubmed: 30661803
Sci Signal. 2018 May 01;11(528):
pubmed: 29717061
Nat Commun. 2020 Aug 12;11(1):4029
pubmed: 32788597
Reproduction. 2017 Jun;153(6):809-820
pubmed: 28348069
Nature. 2020 May;581(7806):100-105
pubmed: 32376951
Nat Rev Gastroenterol Hepatol. 2017 Mar;14(3):170-184
pubmed: 28053338
Nat Rev Nephrol. 2020 Sep;16(9):489-508
pubmed: 32704047
J Exp Med. 2011 Dec 19;208(13):2625-32
pubmed: 22162830
Oncoimmunology. 2019 Apr 3;8(7):1591878
pubmed: 31143510
Nat Cell Biol. 2015 Jun;17(6):759-70
pubmed: 25961502
Dtsch Arztebl Int. 2018 Feb 9;115(6):91-97
pubmed: 29478438
Nat Rev Endocrinol. 2014 Jun;10(6):322-37
pubmed: 24663220
Cancer Discov. 2019 Sep;9(9):1268-1287
pubmed: 31263025
Cell Death Differ. 2012 Jan;19(1):162-9
pubmed: 21701497
J Bone Miner Res. 2010 Jul;25(7):1572-80
pubmed: 20200951
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15077-82
pubmed: 14657337
Eur J Paediatr Neurol. 2016 Jan;20(1):69-79
pubmed: 26542466
Nat Neurosci. 2013 May;16(5):532-42
pubmed: 23542691
J Cell Biol. 2015 Jul 6;210(1):153-68
pubmed: 26150392
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20364-71
pubmed: 24277826
Neuron. 2020 Mar 18;105(6):961-973
pubmed: 32191859
Nature. 2013 Nov 14;503(7475):272-6
pubmed: 24089213
Dev Cell. 2021 Apr 5;56(7):906-918
pubmed: 33689692
Science. 2013 Apr 26;340(6131):471-5
pubmed: 23620051
Nat Rev Drug Discov. 2017 Nov;16(11):755-772
pubmed: 28983101
Am J Respir Cell Mol Biol. 2018 Aug;59(2):135-136
pubmed: 30067090
Sci Rep. 2017 Jul 6;7(1):4759
pubmed: 28684853
Dev Cell. 2020 Jul 20;54(2):268-281
pubmed: 32693059
Int Rev Cell Mol Biol. 2019;348:1-68
pubmed: 31810551
Cell Metab. 2016 Sep 13;24(3):402-419
pubmed: 27568548
Mol Endocrinol. 2013 Oct;27(10):1643-54
pubmed: 23960084
J Am Soc Nephrol. 2015 May;26(5):1040-52
pubmed: 25406339
Cancer Cell. 2015 Dec 14;28(6):690-714
pubmed: 26678337
Nature. 2020 Oct;586(7827):120-126
pubmed: 32968282
Trends Neurosci. 2015 Jan;38(1):26-35
pubmed: 25282404
J Am Soc Nephrol. 2016 Aug;27(8):2331-45
pubmed: 26701976
Nat Commun. 2014 Mar 25;5:3496
pubmed: 24667209
Annu Rev Immunol. 2018 Apr 26;36:73-101
pubmed: 29144836
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3325-34
pubmed: 25071185
Cell Metab. 2019 Jan 8;29(1):202-210.e6
pubmed: 30293775
Nat Genet. 2007 Jul;39(7):830-2
pubmed: 17554261
Sci Adv. 2020 Apr 29;6(18):eaax7881
pubmed: 32494661
Nat Neurosci. 2018 Feb;21(2):207-217
pubmed: 29311744
Cell Death Dis. 2021 Mar 5;12(3):248
pubmed: 33674554
Nature. 2021 Apr;592(7856):799-803
pubmed: 33854232
Nat Commun. 2017 Jun 07;8:15750
pubmed: 28589926
J Biol Chem. 2014 Sep 19;289(38):26525-26532
pubmed: 25077962
Science. 2004 May 21;304(5674):1158-60
pubmed: 15087508
Cell. 2009 Jun 12;137(6):1062-75
pubmed: 19524509
Nat Rev Drug Discov. 2017 Jul;16(7):487-511
pubmed: 28529316
J Clin Invest. 2014 Jun;124(6):2410-24
pubmed: 24789905
Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):803-816
pubmed: 29524522
Ann Rheum Dis. 2016 Jun;75(6):1203-10
pubmed: 26113650
Cell Death Dis. 2017 Jan 19;8(1):e2565
pubmed: 28102843
Autophagy. 2021 Oct;17(10):3082-3095
pubmed: 33218264
Cell Rep. 2013 Oct 17;5(1):61-9
pubmed: 24095740
Autophagy. 2016 May 3;12(5):814-32
pubmed: 26986811
Circ Res. 2017 May 26;120(11):1812-1824
pubmed: 28546358
J Clin Invest. 2015 Jan;125(1):55-64
pubmed: 25654551
Nature. 2020 Mar;579(7798):260-264
pubmed: 32132711
J Biol Chem. 2010 Jul 16;285(29):22576-91
pubmed: 20452972
Front Cell Dev Biol. 2020 Mar 04;8:138
pubmed: 32195258
mBio. 2017 Nov 21;8(6):
pubmed: 29162711
Sci Rep. 2018 Sep 20;8(1):14133
pubmed: 30237523
Nature. 2011 Jan 20;469(7330):323-35
pubmed: 21248839
Autophagy. 2014;10(11):1989-2005
pubmed: 25484094
J Cell Biol. 2018 May 7;217(5):1613-1622
pubmed: 29500189
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17071-6
pubmed: 24067654
Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1817-26
pubmed: 23610405
Exp Lung Res. 2018 Mar;44(2):89-97
pubmed: 29543496
N Engl J Med. 2013 Feb 14;368(7):651-62
pubmed: 23406030
Mol Cell. 2016 Jun 16;62(6):967-981
pubmed: 27211868
Neuron. 2020 Mar 4;105(5):813-821.e6
pubmed: 31899071
Am J Respir Crit Care Med. 2016 Nov 15;194(10):1196-1207
pubmed: 27579514
EMBO Rep. 2018 Jul;19(7):
pubmed: 29752334
J Biol Chem. 2014 Feb 7;289(6):3547-54
pubmed: 24324270
Cell Metab. 2011 Jun 8;13(6):655-67
pubmed: 21641547
Exp Neurol. 2012 Nov;238(1):22-8
pubmed: 21095248
Microb Cell. 2016 Dec 30;4(1):1-5
pubmed: 28357383
Nat Microbiol. 2017 May 08;2:17066
pubmed: 28481361
Cell Death Dis. 2019 Jan 28;10(2):78
pubmed: 30692509
Cell Metab. 2019 Oct 1;30(4):754-767.e9
pubmed: 31422903
Cancer Discov. 2019 Sep;9(9):1167-1181
pubmed: 31434711
Cancer Discov. 2015 Apr;5(4):410-23
pubmed: 25673642
Nat Rev Cardiol. 2017 Nov;14(11):637-653
pubmed: 28660894
Nature. 2000 Aug 24;406(6798):902-6
pubmed: 10972293
Cell. 2014 May 22;157(5):1013-22
pubmed: 24855941
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14955-9
pubmed: 8962163
Nat Commun. 2020 Jul 30;11(1):3806
pubmed: 32732922
Hum Mol Genet. 2010 Jul 1;19(13):2606-15
pubmed: 20388642
Science. 2015 Feb 20;347(6224):878-82
pubmed: 25700520
Nat Commun. 2016 Feb 03;7:10533
pubmed: 26837467
Dev Cell. 2016 Oct 10;39(1):116-130
pubmed: 27693508
Neurobiol Dis. 2012 Mar;45(3):962-72
pubmed: 22198378
Brain. 2014 Mar;137(Pt 3):834-48
pubmed: 24477431
Ann Neurol. 2018 Jun;83(6):1075-1088
pubmed: 29604224
Nat Commun. 2013;4:2300
pubmed: 23939249
Autophagy. 2016;12(2):410-23
pubmed: 26727396
Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):
pubmed: 33785595
Autophagy. 2020 May;16(5):826-841
pubmed: 31366282
Autophagy. 2018;14(7):1110-1128
pubmed: 29863947
Nature. 2012 Jan 18;481(7382):511-5
pubmed: 22258505
Autophagy. 2020 Apr;16(4):615-625
pubmed: 31238825
EMBO J. 2018 Sep 3;37(17):
pubmed: 30076131
Neuron. 2017 Mar 8;93(5):1015-1034
pubmed: 28279350
Exp Eye Res. 2013 Oct;115:263-73
pubmed: 23872361
J Neuropathol Exp Neurol. 2016 Apr;75(4):299-305
pubmed: 26945032
Nat Commun. 2013;4:2308
pubmed: 23917356
Nat Med. 2016 Dec;22(12):1428-1438
pubmed: 27841876
J Clin Invest. 2012 May;122(5):1764-76
pubmed: 22505452
Blood. 2020 Jun 25;135(26):2388-2401
pubmed: 32232483
Cell. 2013 Aug 29;154(5):1085-1099
pubmed: 23954414
Int Rev Cell Mol Biol. 2020;352:115-158
pubmed: 32334814
Sci Rep. 2021 Mar 11;11(1):5767
pubmed: 33707562
Autophagy. 2018;14(2):269-282
pubmed: 29172997
Nat Immunol. 2014 Dec;15(12):1152-61
pubmed: 25362489
Cell Death Dis. 2018 Sep 24;9(10):981
pubmed: 30250019
Cell Death Differ. 2020 Mar;27(3):833-842
pubmed: 31659280
Nat Commun. 2014;5:3056
pubmed: 24445999
Nat Immunol. 2010 Jan;11(1):55-62
pubmed: 19898471
Circ Res. 2013 Nov 8;113(11):1253-64
pubmed: 24081881
Cell Death Dis. 2016 Jan 14;7:e2059
pubmed: 26775710
Autophagy. 2019 May;15(5):827-842
pubmed: 30669939
Autophagy. 2020 Nov;16(11):2069-2083
pubmed: 31920150
J Peripher Nerv Syst. 2019 Mar;24(1):150-155
pubmed: 30680846
Aging (Albany NY). 2011 Sep;3(9):821-8
pubmed: 21931183
Autophagy. 2018;14(5):880-897
pubmed: 29172924
Cell Death Dis. 2020 Jul 6;11(7):502
pubmed: 32632162
Autophagy. 2010 Jan;6(1):110-25
pubmed: 20110774
J Cell Biol. 2015 Aug 31;210(5):705-16
pubmed: 26323688
Cell. 2017 Jun 29;170(1):199-212.e20
pubmed: 28666119
Nature. 2015 Jun 18;522(7556):354-8
pubmed: 26040720
EMBO Mol Med. 2013 May;5(5):691-706
pubmed: 23606558
Autophagy. 2016 Jul 2;12(7):1094-104
pubmed: 27158844
Cell Death Discov. 2020 Apr 17;6:21
pubmed: 32337073
Sci Immunol. 2020 Oct 16;5(52):
pubmed: 33067381
Nat Commun. 2019 Sep 13;10(1):4176
pubmed: 31519908
Lancet Neurol. 2018 Sep;17(9):802-815
pubmed: 30129476
Am J Pathol. 2012 Jan;180(1):275-92
pubmed: 22062220
Am J Hum Genet. 2011 Jun 10;88(6):827-838
pubmed: 21636066
Elife. 2014 Nov 11;3:
pubmed: 25385531
Nat Microbiol. 2021 Mar;6(3):366-379
pubmed: 33462436
Brain. 2019 May 1;142(5):1242-1254
pubmed: 30968111
J Clin Invest. 2015 Jan;125(1):85-93
pubmed: 25654554
Nat Cell Biol. 2013 Oct;15(10):1197-1205
pubmed: 24036476
Nat Neurosci. 2010 May;13(5):567-76
pubmed: 20383138
J Clin Invest. 2012 Feb;122(2):538-44
pubmed: 22232211
Genes Dev. 2020 May 1;34(9-10):688-700
pubmed: 32193353
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Cells. 2020 Oct 20;9(10):
pubmed: 33092174
J Biol Chem. 2003 Oct 31;278(44):43628-35
pubmed: 12930822
Autophagy. 2012 Sep;8(9):1394-6
pubmed: 22889942
Dev Cell. 2021 Feb 22;56(4):427-442.e5
pubmed: 33422265
Cancer Discov. 2014 Aug;4(8):905-13
pubmed: 24875860
PLoS One. 2016 Jan 25;11(1):e0147792
pubmed: 26807733
Sci Rep. 2018 Jan 11;8(1):489
pubmed: 29323257
Aging Cell. 2013 Jun;12(3):478-88
pubmed: 23521856
Mol Cell Biol. 2012 Jul;32(13):2570-84
pubmed: 22547685
Mol Cell. 2019 Oct 17;76(2):268-285
pubmed: 31585693
Am J Physiol Renal Physiol. 2011 Jan;300(1):F236-44
pubmed: 20943770
Cell Metab. 2014 Sep 2;20(3):417-32
pubmed: 25043815
Science. 2017 Sep 8;357(6355):1047-1052
pubmed: 28751470
Nat Rev Mol Cell Biol. 2013 Mar;14(3):133-9
pubmed: 23361334
Nat Med. 2010 Nov;16(11):1313-20
pubmed: 21037586
Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11228-E11237
pubmed: 29233943
Nat Genet. 2001 Oct;29(2):160-5
pubmed: 11586297
Autophagy. 2018;14(11):1991-2006
pubmed: 30025494
Cell Death Differ. 2015 Mar;22(3):488-98
pubmed: 25571975
Autophagy. 2011 Jan;7(1):104-6
pubmed: 21048426
Circ Res. 2015 Jan 16;116(2):264-78
pubmed: 25332205
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17450-5
pubmed: 24101526
J Hepatol. 2011 Dec;55(6):1353-60
pubmed: 21803012
Cell. 2010 Jun 25;141(7):1146-58
pubmed: 20541250
Cardiovasc Res. 2018 Jan 1;114(1):90-102
pubmed: 29036556
Cell. 2018 Oct 4;175(2):429-441.e16
pubmed: 30245008
Sci Transl Med. 2011 Nov 16;3(109):109ra117
pubmed: 22089453
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9745-50
pubmed: 18621691
Nat Cell Biol. 2010 Sep;12(9):863-75
pubmed: 20711182
J Mol Biol. 2016 May 8;428(9 Pt A):1659-80
pubmed: 26953261
J Biol Chem. 2003 Jul 4;278(27):25009-13
pubmed: 12719433
Am J Pathol. 2010 Apr;176(4):1767-78
pubmed: 20150430
Nat Commun. 2018 Dec 18;9(1):5358
pubmed: 30560896
Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F156-67
pubmed: 23152292
J Clin Invest. 2016 Mar 1;126(3):809-20
pubmed: 26928034
J Clin Invest. 2020 Sep 1;130(9):5011-5026
pubmed: 32804155
J Biol Chem. 2015 Sep 25;290(39):23670-9
pubmed: 26221040
Autophagy. 2016;12(3):515-28
pubmed: 26761524
Annu Rev Cancer Biol. 2017 Mar;1:19-39
pubmed: 31119201
Cell Host Microbe. 2010 Feb 18;7(2):115-27
pubmed: 20159618
Nat Cancer. 2020 Sep;1(9):923-934
pubmed: 34476408
Cell Death Differ. 2019 Mar;26(4):690-702
pubmed: 30728463
Sci Transl Med. 2018 Sep 19;10(459):
pubmed: 30232229
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6
pubmed: 24821797
Free Radic Biol Med. 2014 Apr;69:108-15
pubmed: 24418158
Toxicol Appl Pharmacol. 2016 Oct 15;309:101-10
pubmed: 27594529
Cell Death Dis. 2015 Nov 12;6:e1972
pubmed: 26561782
Dev Cell. 2020 Jan 6;52(1):69-87.e8
pubmed: 31813797
Int J Biochem Cell Biol. 2018 Sep;102:71-75
pubmed: 29997057
Hum Mol Genet. 2012 Jan 1;21(1):101-14
pubmed: 21954231
Biochem Biophys Res Commun. 2017 Jan 22;482(4):1334-1340
pubmed: 27939888
Nat Rev Mol Cell Biol. 2020 Aug;21(8):439-458
pubmed: 32372019
Nat Immunol. 2020 Oct;21(10):1160-1171
pubmed: 32747819
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23724-23734
pubmed: 31699817
Nat Rev Immunol. 2017 May;17(5):306-321
pubmed: 28317925
Aging Cell. 2018 Feb;17(1):
pubmed: 29024336
Autophagy. 2021 Nov;17(11):3530-3546
pubmed: 33459136
J Hepatol. 2020 Jun;72(6):1122-1131
pubmed: 32001325
Autophagy. 2015;11(10):1821-32
pubmed: 26292183
EBioMedicine. 2019 Feb;40:118-134
pubmed: 30711520
Oncoimmunology. 2018 Oct 1;8(1):e1498285
pubmed: 30546941
Neuron. 2018 Jul 11;99(1):83-97.e7
pubmed: 29937275
Nature. 2013 Oct 10;502(7470):254-7
pubmed: 24089205
Int Rev Cell Mol Biol. 2019;348:69-121
pubmed: 31810556
J Immunol. 2017 Feb 1;198(3):1081-1092
pubmed: 28031336
Mol Cell. 2011 Jun 24;42(6):719-30
pubmed: 21700219
Autophagy. 2020 Oct;16(10):1889-1904
pubmed: 31944172
Elife. 2016 Jan 26;5:
pubmed: 26812546
Autophagy. 2013 Apr;9(4):476-95
pubmed: 23348054
Cell. 2016 Jul 14;166(2):288-298
pubmed: 27419869
Autophagy. 2014 Jan;10(1):7-19
pubmed: 24225636
Autophagy. 2008 Feb;4(2):176-84
pubmed: 18059160
Cell Death Dis. 2020 Feb 3;11(2):87
pubmed: 32015340
JCI Insight. 2020 Sep 3;5(17):
pubmed: 32780726
Nature. 2018 Jun;558(7708):136-140
pubmed: 29849149
Nat Cell Biol. 2020 Oct;22(10):1252-1263
pubmed: 32989250
Autophagy. 2015;11(8):1280-92
pubmed: 26061908
Autophagy. 2014;10(11):1965-77
pubmed: 25484092
Front Pharmacol. 2018 Feb 01;9:34
pubmed: 29449811
Nat Commun. 2014 Sep 26;5:4934
pubmed: 25255859
Curr Biol. 2021 Jul 26;31(14):3028-3039.e7
pubmed: 34019822
EMBO J. 2019 Jan 15;38(2):
pubmed: 30559329