The effect of α-MSH treatment on the hypothalamic-pituitary-gonad axis in the cichlid fish Oreochromis mossambicus.
Alpha-MSH
Fish ovary
Follicular development
Gonadotropin-releasing hormone
Luteinizing hormone
Oreochromis mossambicus
Journal
Fish physiology and biochemistry
ISSN: 1573-5168
Titre abrégé: Fish Physiol Biochem
Pays: Netherlands
ID NLM: 100955049
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
10
05
2021
accepted:
14
08
2021
pubmed:
31
8
2021
medline:
5
1
2022
entrez:
30
8
2021
Statut:
ppublish
Résumé
In this investigation, we examined the influence of alpha-melanocyte stimulating hormone (α-MSH), a proopiomelanocortin-derived peptide, along the hypothalamic-pituitary-gonad axis in a cichlid fish Oreochromis mossambicus. Administration of α-MSH (40 µg/0.1 ml saline) for 22 days did not affect the number of stage I (previtellogenic) follicles but caused significant reduction in the mean numbers of previtellogenic (stages II and III), vitellogenic (stage IV) and preovulatory (stage V) follicles compared to those of controls. While the gonadosomatic index was significantly lower, the rate of follicular atresia in stages II, III and IV remained significantly higher in α-MSH-treated fish compared to the controls. Furthermore, the mean percent area of gonadotropin-releasing hormone-immunoreactive (GnRH-ir) fibres and luteinizing hormone-immunoreactive (LH-ir) cells were significantly reduced in the proximal pars distalis of the pituitary gland in α-MSH-treated fish compared with the controls. Together, our findings suggest for the first time that the treatment of α-MSH blocks the follicular developmental process during the ovarian cycle, possibly through the inhibition of GnRH-LH pathway in teleosts.
Identifiants
pubmed: 34460040
doi: 10.1007/s10695-021-01005-9
pii: 10.1007/s10695-021-01005-9
doi:
Substances chimiques
Gonadotropin-Releasing Hormone
33515-09-2
alpha-MSH
581-05-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1659-1668Subventions
Organisme : Science and Engineering Research Board (IN)
ID : EEQ/414/2017
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature B.V.
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