Rational Design and Experimental Analysis of Short-Oligonucleotide Substrate Specificity for Targeting Bacterial Nucleases.
Bacterial Proteins
/ chemistry
Biosensing Techniques
Chromatography, Liquid
Deoxyribonucleases
/ genetics
Drug Design
Mass Spectrometry
Models, Molecular
Molecular Docking Simulation
Nucleic Acid Conformation
Oligonucleotides
/ chemistry
Protein Conformation
Staphylococcus aureus
/ metabolism
Substrate Specificity
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
09 09 2021
09 09 2021
Historique:
pubmed:
31
8
2021
medline:
15
12
2021
entrez:
30
8
2021
Statut:
ppublish
Résumé
An undecamer oligonucleotide probe based on a pair of deoxythymidines flanked by several modified nucleotides is a specific and highly efficient biosensor for micrococcal nuclease (MNase), an endonuclease produced by
Identifiants
pubmed: 34460263
doi: 10.1021/acs.jmedchem.1c00884
pmc: PMC8436206
doi:
Substances chimiques
Bacterial Proteins
0
Oligonucleotides
0
Deoxyribonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12855-12864Références
J Med Chem. 2006 Oct 19;49(21):6177-96
pubmed: 17034125
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Sci Rep. 2019 Jun 20;9(1):8853
pubmed: 31222049
Angew Chem Int Ed Engl. 2013 Sep 9;52(37):9719-22
pubmed: 23881724
Bioconjug Chem. 2008 Mar;19(3):686-92
pubmed: 18260609
Anal Chim Acta. 2019 Apr 25;1054:157-166
pubmed: 30712586
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2551-5
pubmed: 288045
Biochemistry. 1987 Mar 10;26(5):1289-300
pubmed: 3567171
J Biomed Opt. 2018 Sep;23(9):1-11
pubmed: 30255671
Nat Med. 2014 Mar;20(3):301-6
pubmed: 24487433
ACS Infect Dis. 2020 Feb 14;6(2):215-223
pubmed: 31823600
Org Biomol Chem. 2020 Sep 21;18(35):6935-6948
pubmed: 32936176
Chem Commun (Camb). 2016 Oct 25;52(83):12346-12349
pubmed: 27722495
Proteins. 1989;5(3):183-201
pubmed: 2780539
Cancers (Basel). 2021 Jan 13;13(2):
pubmed: 33451046
Sensors (Basel). 2014 Jul 11;14(7):12437-50
pubmed: 25019631
Q Rev Biophys. 2011 Feb;44(1):1-93
pubmed: 20854710
ACS Cent Sci. 2019 Dec 26;5(12):1929-1936
pubmed: 31893222
Biosens Bioelectron. 2013 Apr 15;42:467-73
pubmed: 23238320
Chem Rev. 2009 May;109(5):1948-98
pubmed: 19301873