Temporal metabolic response to mRNA COVID-19 vaccinations in oncology patients.
Adult
Aged
Aged, 80 and over
Axilla
COVID-19
/ prevention & control
COVID-19 Vaccines
/ administration & dosage
Female
Fluorodeoxyglucose F18
/ metabolism
Humans
Lymph Nodes
/ diagnostic imaging
Male
Middle Aged
Neoplasms
/ immunology
Pectoralis Muscles
Positron Emission Tomography Computed Tomography
Time Factors
Vaccines, Synthetic
/ administration & dosage
mRNA Vaccines
COVID-19
FDG
Vaccine
Journal
Annals of nuclear medicine
ISSN: 1864-6433
Titre abrégé: Ann Nucl Med
Pays: Japan
ID NLM: 8913398
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
15
06
2021
accepted:
22
08
2021
pubmed:
1
9
2021
medline:
25
2
2023
entrez:
31
8
2021
Statut:
ppublish
Résumé
mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic response is unknown. We here present a temporal metabolic response to mRNA COVID-19 vaccination in oncology patients undergoing standard of care FDG PET. 262 oncology patients undergoing standard of care FDG PET were included in the analysis. 231 patients had at least one dose of mRNA COVID-19 vaccine while 31 patients had not been vaccinated. The SUVmax of the lymph nodes ipsilateral to the vaccination was compared to the contralateral to obtain an absolute change in SUVmax (ΔSUVmax). ΔSUVmax was more significant at shorter times between FDG PET imaging and COVID-19 mRNA vaccination, with a median ΔSUVmax of 2.6 (0-7 days), 0.8 (8-14 days), and 0.3 (> 14 days), respectively. Consideration should be given to performing FDG PET at least 2 weeks after the COVID-19 vaccine.
Sections du résumé
BACKGROUND
BACKGROUND
mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic response is unknown. We here present a temporal metabolic response to mRNA COVID-19 vaccination in oncology patients undergoing standard of care FDG PET.
METHODS
METHODS
262 oncology patients undergoing standard of care FDG PET were included in the analysis. 231 patients had at least one dose of mRNA COVID-19 vaccine while 31 patients had not been vaccinated. The SUVmax of the lymph nodes ipsilateral to the vaccination was compared to the contralateral to obtain an absolute change in SUVmax (ΔSUVmax).
RESULTS
RESULTS
ΔSUVmax was more significant at shorter times between FDG PET imaging and COVID-19 mRNA vaccination, with a median ΔSUVmax of 2.6 (0-7 days), 0.8 (8-14 days), and 0.3 (> 14 days), respectively.
CONCLUSION
CONCLUSIONS
Consideration should be given to performing FDG PET at least 2 weeks after the COVID-19 vaccine.
Identifiants
pubmed: 34463888
doi: 10.1007/s12149-021-01675-8
pii: 10.1007/s12149-021-01675-8
pmc: PMC8406005
doi:
Substances chimiques
COVID-19 Vaccines
0
Vaccines, Synthetic
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1264-1269Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. The Author(s).
Références
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