Natural Progression of Helicobacter pylori-Negative Gastritis with Lymphoid Follicles in Children: Prospective Evaluation and Outcome.
Adolescent
Biopsy
Child
Child, Preschool
Disease Progression
Endoscopy, Digestive System
Female
Gastritis
/ diagnosis
Helicobacter Infections
/ complications
Helicobacter pylori
Humans
Lymphoid Tissue
/ immunology
Male
Precancerous Conditions
/ diagnosis
Prospective Studies
Stomach
/ immunology
Treatment Outcome
Journal
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
ISSN: 2148-5607
Titre abrégé: Turk J Gastroenterol
Pays: Turkey
ID NLM: 9515841
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
entrez:
31
8
2021
pubmed:
1
9
2021
medline:
22
1
2022
Statut:
ppublish
Résumé
The association of Helicobacter pylori-negative gastritis with lymphoid follicles (LFs) in children is still unclear. Therefore, we aimed to investigate the natural history and significance of H. pylori-negative gastritis with LFs in children. We identified children with histologically proven H. pylori-negative gastritis with LFs between June 2014 and January 2017. The children were invited for a follow-up examination. The clinical, endoscopic, and histological findings of the index esophagogastroduodenoscopy (EGD) were revised and compared to the follow-up findings. A total of 754 children underwent EGD. Among the 48 children diagnosed with H. pylori-negative gastritis, 17 (35.41%) had gastric LFs. Eight agreed to participate in the study. The mean follow-up was 25.58 ± 4.52 (range, 20.53-35.73) months. Three children still had histologic findings of chronic gastritis with LFs. Four children had resolution of the gastritis but still had LFs, and 1 patient had resolution of both the gastritis and LFs. LFs were still present in children with H. pylori-negative gastritis after a mean follow-up of 2 years, and in some children, despite resolution of the gastritis. Therefore, this histological finding might be a non-pathological feature in children and does not need any contribution or follow-up.
Sections du résumé
BACKGROUND
BACKGROUND
The association of Helicobacter pylori-negative gastritis with lymphoid follicles (LFs) in children is still unclear. Therefore, we aimed to investigate the natural history and significance of H. pylori-negative gastritis with LFs in children.
METHODS
METHODS
We identified children with histologically proven H. pylori-negative gastritis with LFs between June 2014 and January 2017. The children were invited for a follow-up examination. The clinical, endoscopic, and histological findings of the index esophagogastroduodenoscopy (EGD) were revised and compared to the follow-up findings.
RESULTS
RESULTS
A total of 754 children underwent EGD. Among the 48 children diagnosed with H. pylori-negative gastritis, 17 (35.41%) had gastric LFs. Eight agreed to participate in the study. The mean follow-up was 25.58 ± 4.52 (range, 20.53-35.73) months. Three children still had histologic findings of chronic gastritis with LFs. Four children had resolution of the gastritis but still had LFs, and 1 patient had resolution of both the gastritis and LFs.
CONCLUSION
CONCLUSIONS
LFs were still present in children with H. pylori-negative gastritis after a mean follow-up of 2 years, and in some children, despite resolution of the gastritis. Therefore, this histological finding might be a non-pathological feature in children and does not need any contribution or follow-up.
Identifiants
pubmed: 34464320
doi: 10.5152/tjg.2021.20595
pmc: PMC8975473
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
575-580Références
Pathology. 2015 Jan;47(1):38-44
pubmed: 25474513
Front Pediatr. 2014 Jan 20;2:3
pubmed: 24479108
Aliment Pharmacol Ther. 2015 Jan;41(2):218-26
pubmed: 25376264
Gut. 2017 Jan;66(1):6-30
pubmed: 27707777
Virchows Arch. 2018 Nov;473(5):533-550
pubmed: 30255340
Malays J Pathol. 2008 Jun;30(1):27-30
pubmed: 19108408
Clin Exp Gastroenterol. 2017 Aug 11;10:195-201
pubmed: 28860835
Tunis Med. 2012 Nov;90(11):789-92
pubmed: 23197056
J Clin Pathol. 1995 Apr;48(4):325-9
pubmed: 7615851
Eur J Gastroenterol Hepatol. 2004 Nov;16(11):1183-8
pubmed: 15489580
Intern Med. 2014;53(2):83-8
pubmed: 24429445
J Gastroenterol Hepatol. 2008 Jun;23(6):943-7
pubmed: 17614956
Pediatr Dev Pathol. 2000 Mar-Apr;3(2):177-9
pubmed: 10679037
J Paediatr Child Health. 2014 Aug;50(8):605-9
pubmed: 24925694
Expert Opin Pharmacother. 2008 Mar;9(4):577-85
pubmed: 18312159
Am J Surg Pathol. 1996 Oct;20(10):1161-81
pubmed: 8827022
Am J Gastroenterol. 2013 Jan;108(1):65-71
pubmed: 23147524