Cardiac-specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP-binding proteins.
cardiac homeostasis
cardiac remodeling
heart failure
protein prenylation
Journal
The Journal of pathology
ISSN: 1096-9896
Titre abrégé: J Pathol
Pays: England
ID NLM: 0204634
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
04
08
2021
received:
05
08
2020
accepted:
26
08
2021
pubmed:
2
9
2021
medline:
4
1
2022
entrez:
1
9
2021
Statut:
ppublish
Résumé
The mevalonate pathway is essential for cholesterol biosynthesis. Previous studies have suggested that the key enzyme in this pathway, farnesyl diphosphate synthase (FDPS), regulates the cardiovascular system. We used human samples and mice that were deficient in cardiac FDPS (c-Fdps
Substances chimiques
Geranyltranstransferase
EC 2.5.1.10
GTP-Binding Proteins
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
438-450Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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