Increased network centrality of the anterior insula in early abstinence from alcohol.
alcohol use disorder
functional connectivity
insula
naltrexone
resting-state fMRI
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
07
08
2021
received:
10
03
2021
accepted:
11
08
2021
pubmed:
2
9
2021
medline:
23
2
2022
entrez:
1
9
2021
Statut:
ppublish
Résumé
Abnormal resting-state functional connectivity, as measured by functional magnetic resonance imaging (MRI), has been reported in alcohol use disorders (AUD), but findings are so far inconsistent. Here, we exploited recent developments in graph-theoretical analyses, enabling improved resolution and fine-grained representation of brain networks, to investigate functional connectivity in 35 recently detoxified alcohol dependent patients versus 34 healthy controls. Specifically, we focused on the modular organization, that is, the presence of tightly connected substructures within a network, and on the identification of brain regions responsible for network integration using an unbiased approach based on a large-scale network composed of more than 600 a priori defined nodes. We found significant reductions in global connectivity and region-specific disruption in the network topology in patients compared with controls. Specifically, the basal brain and the insular-supramarginal cortices, which form tightly coupled modules in healthy subjects, were fragmented in patients. Further, patients showed a strong increase in the centrality of the anterior insula, which exhibited stronger connectivity to distal cortical regions and weaker connectivity to the posterior insula. Anterior insula centrality, a measure of the integrative role of a region, was significantly associated with increased risk of relapse. Exploratory analysis suggests partial recovery of modular structure and insular connectivity in patients after 2 weeks. These findings support the hypothesis that, at least during the early stages of abstinence, the anterior insula may drive exaggerated integration of interoceptive states in AUD patients with possible consequences for decision making and emotional states and that functional connectivity is dynamically changing during treatment.
Identifiants
pubmed: 34467604
doi: 10.1111/adb.13096
pmc: PMC9286046
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13096Informations de copyright
© 2021 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
Références
Neuroimage. 2020 May 1;211:116603
pubmed: 32036020
Nature. 2005 Feb 24;433(7028):895-900
pubmed: 15729348
Hum Brain Mapp. 2015 Dec;36(12):4808-18
pubmed: 26368063
Front Hum Neurosci. 2018 Dec 21;12:513
pubmed: 30631268
Sci Rep. 2016 Aug 18;6:32060
pubmed: 27534708
Neuroimage Clin. 2018 Mar 01;18:682-693
pubmed: 29876260
Nervenarzt. 2009 Sep;80(9):1085-92
pubmed: 19471901
Neuroimage. 2012 Mar;60(1):252-62
pubmed: 22206965
Neuroimage. 2012 Feb 15;59(4):3889-900
pubmed: 22119652
Brain. 2014 Aug;137(Pt 8):2382-95
pubmed: 25057133
Addict Biol. 2018 Jan;23(1):425-436
pubmed: 28247526
J Neurosci. 2010 Jul 14;30(28):9477-87
pubmed: 20631176
JAMA Psychiatry. 2019 Jul 1;76(7):749-758
pubmed: 30942831
Addict Biol. 2017 Jan;22(1):206-217
pubmed: 26040546
Science. 2007 Oct 26;318(5850):655-8
pubmed: 17962567
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2825-30
pubmed: 22308319
Neuropsychopharmacology. 2012 Aug;37(9):2101-8
pubmed: 22534623
Nat Neurosci. 2013 Aug;16(8):1094-100
pubmed: 23817545
Neuroimage Clin. 2015 Nov 18;10:96-106
pubmed: 26793435
Neuroimage. 2017 Feb 1;146:28-39
pubmed: 27865921
Neuroimage. 2010 Dec;53(4):1197-207
pubmed: 20600983
Sci Rep. 2016 Jan 14;6:19250
pubmed: 26763931
Science. 2007 Jan 26;315(5811):531-4
pubmed: 17255515
Sci Adv. 2020 Jun 24;6(26):eaba0154
pubmed: 32637601
Psychiatry Res Neuroimaging. 2019 Feb 28;284:21-28
pubmed: 30640144
Cereb Cortex. 2015 Nov;25(11):4155-68
pubmed: 24935777
PLoS One. 2013 Jul 04;8(7):e68910
pubmed: 23861951
Neuroimage. 2017 May 1;151:45-54
pubmed: 27864080
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7327-31
pubmed: 17452639
Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Feb;69(2 Pt 2):026113
pubmed: 14995526
Addict Biol. 2020 Jan;25(1):e12717
pubmed: 30748046
Sci Rep. 2016 Aug 10;6:31293
pubmed: 27506835
Mol Psychiatry. 2016 Apr;21(4):491-9
pubmed: 26370145
Transl Psychiatry. 2019 Oct 8;9(1):255
pubmed: 31594920
Front Syst Neurosci. 2010 Oct 08;4:147
pubmed: 21031030
Addict Biol. 2018 Mar;23(2):824-835
pubmed: 28699704
Curr Opin Neurobiol. 2001 Apr;11(2):250-7
pubmed: 11301247
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Nat Rev Neurosci. 2009 Jan;10(1):59-70
pubmed: 19096369
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1118-23
pubmed: 18216267
Addict Biol. 2017 Mar;22(2):523-534
pubmed: 26692359
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
Trends Neurosci. 2009 Jan;32(1):56-67
pubmed: 18986715
Brain. 2015 Jan;138(Pt 1):69-79
pubmed: 25367022
Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11583-8
pubmed: 23798414
Addict Biol. 2022 Jan;27(1):e13096
pubmed: 34467604
Hum Brain Mapp. 2019 Dec 1;40(17):4941-4951
pubmed: 31379038
Addict Biol. 2020 Mar;25(2):e12866
pubmed: 31859437
Addict Biol. 2020 May;25(3):e12744
pubmed: 30907042
Addict Behav. 2019 Dec;99:106009
pubmed: 31487578
Trends Cogn Sci. 2009 Sep;13(9):372-80
pubmed: 19716751
Front Neurosci. 2017 Aug 03;11:441
pubmed: 28824364
Br Med J. 1964 Jul 18;2(5402):177
pubmed: 14150898
JAMA. 2014 May 14;311(18):1889-900
pubmed: 24825644
Behav Neurol. 2000;12(4):191-200
pubmed: 11568431
Eur Neuropsychopharmacol. 2015 Dec;25(12):2230-9
pubmed: 26481907
Neuropsychopharmacology. 2020 Apr;45(5):842-850
pubmed: 31711065
Lancet Psychiatry. 2016 Aug;3(8):760-773
pubmed: 27475769
Curr Biol. 2017 Jun 19;27(12):R580-R586
pubmed: 28633023
Transl Psychiatry. 2020 May 18;10(1):150
pubmed: 32424183
Sci Rep. 2012;2:336
pubmed: 22468223
Addict Biol. 2018 Jul;23(4):961-968
pubmed: 30043407
Psychopharmacology (Berl). 2017 May;234(9-10):1623-1631
pubmed: 28378203
Cell. 2017 Jun 1;169(6):1029-1041.e16
pubmed: 28575667
Phys Rev Lett. 2001 Nov 5;87(19):198701
pubmed: 11690461