Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 09 2021
02 09 2021
Historique:
received:
21
12
2020
accepted:
28
07
2021
entrez:
3
9
2021
pubmed:
4
9
2021
medline:
14
9
2021
Statut:
epublish
Résumé
State-of-the-art silicon probes for electrical recording from neurons have thousands of recording sites. However, due to volume limitations there are typically many fewer wires carrying signals off the probe, which restricts the number of channels that can be recorded simultaneously. To overcome this fundamental constraint, we propose a method called electrode pooling that uses a single wire to serve many recording sites through a set of controllable switches. Here we present the framework behind this method and an experimental strategy to support it. We then demonstrate its feasibility by implementing electrode pooling on the Neuropixels 1.0 electrode array and characterizing its effect on signal and noise. Finally we use simulations to explore the conditions under which electrode pooling saves wires without compromising the content of the recordings. We make recommendations on the design of future devices to take advantage of this strategy.
Identifiants
pubmed: 34475396
doi: 10.1038/s41467-021-25443-4
pii: 10.1038/s41467-021-25443-4
pmc: PMC8413349
doi:
Substances chimiques
Silicon
Z4152N8IUI
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5245Subventions
Organisme : NINDS NIH HHS
ID : R01 NS111477
Pays : United States
Informations de copyright
© 2021. The Author(s).
Références
IEEE Trans Biomed Circuits Syst. 2010 Jun;4(3):149-61
pubmed: 23853339
Nature. 2017 Nov 8;551(7679):232-236
pubmed: 29120427
Elife. 2020 Apr 14;9:
pubmed: 32286224
IEEE Trans Biomed Circuits Syst. 2017 Jun;11(3):510-522
pubmed: 28422663
IEEE Trans Biomed Circuits Syst. 2011 Oct;5(5):403-12
pubmed: 23852173
J Neurosci Methods. 2016 May 1;264:65-77
pubmed: 26930629
Science. 2021 Apr 16;372(6539):
pubmed: 33859006
IEEE Trans Biomed Circuits Syst. 2014 Oct;8(5):648-59
pubmed: 25343768
Nano Lett. 2016 Nov 9;16(11):6857-6862
pubmed: 27766885
Elife. 2020 May 19;9:
pubmed: 32427564
J Neurophysiol. 2000 Jul;84(1):401-14
pubmed: 10899214
J Neurosci. 2012 Aug 22;32(34):11798-811
pubmed: 22915121
J Cereb Blood Flow Metab. 2001 Oct;21(10):1133-45
pubmed: 11598490
Sensors (Basel). 2017 Oct 19;17(10):
pubmed: 29048396
Lab Chip. 2015 Jul 7;15(13):2767-80
pubmed: 25973786
Neuron. 2019 Sep 25;103(6):1005-1015
pubmed: 31495645
Front Neurosci. 2015 Jan 06;8:423
pubmed: 25610364
Network. 1998 Nov;9(4):R53-78
pubmed: 10221571
J Mater Chem B. 2015 Jul 7;3(25):4965-4978
pubmed: 26167283
IEEE J Solid-State Circuits. 2017 Jun;52(6):1576-1590
pubmed: 28579632
Elife. 2018 Mar 20;7:
pubmed: 29557782
Science. 2019 Apr 19;364(6437):255
pubmed: 31000656
Nature. 2021 Apr;592(7852):86-92
pubmed: 33473216