Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection.
Adolescent
Anti-HIV Agents
/ therapeutic use
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
/ drug effects
CD8-Positive T-Lymphocytes
/ drug effects
Child
Child, Preschool
Follow-Up Studies
HIV Infections
/ drug therapy
HIV-1
/ drug effects
Humans
Immune System
/ cytology
Receptors, Antigen, T-Cell
/ immunology
Viral Load
/ drug effects
HIV-1
T cell receptor
T cells
T cell receptor clonal expansions
antiretroviral treatment interruption
high throughout sequencing
immune repertoires
thymic output
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
12
2020
accepted:
16
07
2021
entrez:
3
9
2021
pubmed:
4
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
It is intriguing that, unlike adults with HIV-1, children with HIV-1 reach a greater CD4
Identifiants
pubmed: 34475868
doi: 10.3389/fimmu.2021.643189
pmc: PMC8406805
doi:
Substances chimiques
Anti-HIV Agents
0
Receptors, Antigen, T-Cell
0
Types de publication
Clinical Trial, Phase II
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
643189Subventions
Organisme : Medical Research Council
ID : MC_UU_00004/03
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Sandgaard, Margetts, Attenborough, Gkouleli, Adams, Holm, Gibb, Gibbons, Giaquinto, De Rossi, Bamford, Palma, Chain, Gkazi and Klein.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
PLoS Med. 2013 Oct;10(10):e1001542
pubmed: 24204216
J Immunol. 2001 Dec 1;167(11):6663-8
pubmed: 11714838
Methods Mol Biol. 2019;1884:15-42
pubmed: 30465193
AIDS. 2013 Feb 20;27(4):579-89
pubmed: 23135172
Bioinformatics. 2013 Mar 1;29(5):542-50
pubmed: 23303508
Nat Immunol. 2012 Jun 10;13(7):691-700
pubmed: 22683743
Nat Med. 2019 Oct;25(10):1549-1559
pubmed: 31591606
PLoS One. 2018 Apr 23;13(4):e0196239
pubmed: 29684092
PLoS One. 2013 Sep 02;8(9):e73849
pubmed: 24023909
Eur J Haematol. 2008 Jun;80(6):532-9
pubmed: 18284628
AIDS. 2010 Jan 16;24(2):231-41
pubmed: 20010073
AIDS. 2014 Jan 14;28(2):209-14
pubmed: 24072195
Blood. 2009 May 28;113(22):5480-7
pubmed: 19179300
Curr Opin Immunol. 2005 Oct;17(5):468-75
pubmed: 16098723
Nat Commun. 2020 Aug 14;11(1):4089
pubmed: 32796830
J Immunol. 2009 Oct 1;183(7):4329-36
pubmed: 19734223
Clin Exp Immunol. 2018 Feb;191(2):198-202
pubmed: 28976005
Nat Med. 2017 Jan 6;23(1):18-27
pubmed: 28060797
Nature. 2017 Jul 6;547(7661):94-98
pubmed: 28636589
Eur J Pediatr. 1977 Aug 12;125(4):227-34
pubmed: 891567
HIV Med. 2021 Mar;22(3):172-184
pubmed: 33124144
Front Immunol. 2017 Oct 12;8:1267
pubmed: 29075258
Immun Ageing. 2008 Jul 25;5:6
pubmed: 18657274
N Engl J Med. 2006 Nov 30;355(22):2283-96
pubmed: 17135583
Blood. 2011 Aug 25;118(8):2138-49
pubmed: 21734237
Nat Med. 2014 Oct;20(10):1206-10
pubmed: 25242415
J Immunol. 2005 Jun 1;174(11):7446-52
pubmed: 15905594
AIDS. 2001 Sep 28;15(14):1757-64
pubmed: 11579236
J Immunol. 2017 Sep 1;199(5):1696-1705
pubmed: 28754679
Nature. 2017 Jul 6;547(7661):89-93
pubmed: 28636592
Brief Bioinform. 2018 Jul 20;19(4):554-565
pubmed: 28077404
PLoS One. 2013 Oct 23;8(10):e76582
pubmed: 24194841
Front Immunol. 2018 Nov 05;9:2547
pubmed: 30455696