FOXP3 Predicts Response to Treatment in Mycosis Fungoides.
Journal
Acta dermatovenerologica Croatica : ADC
ISSN: 1847-6538
Titre abrégé: Acta Dermatovenerol Croat
Pays: Croatia
ID NLM: 9433781
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
entrez:
3
9
2021
pubmed:
4
9
2021
medline:
26
10
2021
Statut:
ppublish
Résumé
The role of the T-regulatory cells (Tregs) marker forkhead box Protein 3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of previous studies are inconclusive. We aimed at ascertaining the possibility that FOXP3 expression may serve to predict MF stage and response to therapy. Immunohistochemistry staining for FOXP3 was performed on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively graded. Disease stage, progression, and response to treatment were determined based on clinical and imaging evidence, and association with FOXP3 expression was assessed. FOXP3 expression in the dermis correlated with poor response to treatment (P=0.047). A negative non-significant relationship between epidermal FOXP3 expression and clinical stage severity was observed (P=0.17). Dermal FOXP3 expression in MF lesions could be used to predict response to treatment in patients with MF.
Sections du résumé
BACKGROUND
BACKGROUND
The role of the T-regulatory cells (Tregs) marker forkhead box Protein 3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of previous studies are inconclusive.
OBJECTIVE
OBJECTIVE
We aimed at ascertaining the possibility that FOXP3 expression may serve to predict MF stage and response to therapy.
PATIENTS AND METHODS
METHODS
Immunohistochemistry staining for FOXP3 was performed on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively graded. Disease stage, progression, and response to treatment were determined based on clinical and imaging evidence, and association with FOXP3 expression was assessed.
RESULTS
RESULTS
FOXP3 expression in the dermis correlated with poor response to treatment (P=0.047). A negative non-significant relationship between epidermal FOXP3 expression and clinical stage severity was observed (P=0.17).
CONCLUSIONS
CONCLUSIONS
Dermal FOXP3 expression in MF lesions could be used to predict response to treatment in patients with MF.
Substances chimiques
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM