The genomics of heart failure: design and rationale of the HERMES consortium.

Aged Aged, 80 and over Female Genome-Wide Association Study Genomics Heart Failure / genetics Humans Male Middle Aged Prognosis
Association studies Biomarkers Cardiomyopathy Genetics Heart failure

Journal

ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191

Informations de publication

Date de publication:
12 2021
Historique:
revised: 09 06 2021
received: 27 01 2021
accepted: 05 07 2021
pubmed: 5 9 2021
medline: 22 3 2022
entrez: 4 9 2021
Statut: ppublish

Résumé

The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10 HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

Identifiants

DOI: 10.1002/ehf2.13517 PMID: 34480422 PMC: PMC8712846
pubmed: 34480422
doi: 10.1002/ehf2.13517
pmc: PMC8712846
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5531-5541

Subventions

Organisme : Medical Research Council
ID : G0902393
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U10 HL110309
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92019D00031
Pays : United States
Organisme : Medical Research Council
ID : MR/S003754/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U10 HL110336
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL153950
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL110337
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL139731
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001I
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK062413
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U10 HL110342
Pays : United States
Organisme : British Heart Foundation
ID : RE/18/6/34217
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13041
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K006584/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U10 HL110262
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL084904
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL110338
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL110302
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105993
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL110312
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141232
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL110297
Pays : United States

Informations de copyright

© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

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Auteurs

R Thomas Lumbers (RT)

Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Health Data Research UK London, University College London, London, UK.
BHF Research Accelerator, University College London, London, UK.

Sonia Shah (S)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Institute of Cardiovascular Science, University College London, London, UK.

Honghuang Lin (H)

Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.

Tomasz Czuba (T)

Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.

Albert Henry (A)

Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Institute of Cardiovascular Science, University College London, London, UK.

Daniel I Swerdlow (DI)

Institute of Cardiovascular Science, University College London, London, UK.
Department of Medicine, Imperial College London, London, UK.

Anders Mälarstig (A)

Pfizer Worldwide Research & Development, Cambridge, MA, USA.
Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.

Charlotte Andersson (C)

National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark.

Niek Verweij (N)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Michael V Holmes (MV)

Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.
National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.

Johan Ärnlöv (J)

Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
School of Health and Social Sciences, Dalarna University, Falun, Sweden.

Per Svensson (P)

Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
Department of Cardiology, Södersjukhuset, Stockholm, Sweden.

Harry Hemingway (H)

Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Health Data Research UK London, University College London, London, UK.
The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.

Neneh Sallah (N)

Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Health Data Research UK London, University College London, London, UK.
UCL Genetics Institute, University College London, London, UK.

Peter Almgren (P)

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Krishna G Aragam (KG)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

Geraldine Asselin (G)

Montreal Heart Institute, Montreal, Quebec, Canada.

Joshua D Backman (JD)

Regeneron Genetics Center, Tarrytown, NY, USA.

Mary L Biggs (ML)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.

Heather L Bloom (HL)

Division of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA.

Eric Boersma (E)

Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Jeffrey Brandimarto (J)

Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Michael R Brown (MR)

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Hans-Peter Brunner-La Rocca (HP)

Maastricht University Medical Center, Maastricht, The Netherlands.

David J Carey (DJ)

Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.

Mark D Chaffin (MD)

Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Daniel I Chasman (DI)

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Olympe Chazara (O)

Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.

Xing Chen (X)

Pfizer Worldwide Research & Development, Cambridge, MA, USA.

Xu Chen (X)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Jonathan H Chung (JH)

Regeneron Genetics Center, Tarrytown, NY, USA.

William Chutkow (W)

Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

John G F Cleland (JGF)

Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
National Heart and Lung Institute, Imperial College, London, UK.

James P Cook (JP)

Department of Biostatistics, University of Liverpool, Liverpool, UK.

Simon de Denus (S)

Montreal Heart Institute, Montreal, Quebec, Canada.
Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.

Abbas Dehghan (A)

Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.
MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.

Graciela E Delgado (GE)

Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.

Spiros Denaxas (S)

Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Health Data Research UK London, University College London, London, UK.
The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.
The Alan Turing Institute, British Library, London, UK.

Alexander S Doney (AS)

Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

Marcus Dörr (M)

Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.

Samuel C Dudley (SC)

Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Gunnar Engström (G)

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Tõnu Esko (T)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Ghazaleh Fatemifar (G)

Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
Health Data Research UK London, University College London, London, UK.

Stephan B Felix (SB)

Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.

Chris Finan (C)

Institute of Cardiovascular Science, University College London, London, UK.

Ian Ford (I)

Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.

Francoise Fougerousse (F)

Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France.

René Fouodjio (R)

Montreal Heart Institute, Montreal, Quebec, Canada.

Mohsen Ghanbari (M)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Sahar Ghasemi (S)

DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Vilmantas Giedraitis (V)

Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.

Franco Giulianini (F)

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.

John S Gottdiener (JS)

Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.

Stefan Gross (S)

Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.

Daníel F Guðbjartsson (DF)

deCODE genetics/Amgen Inc., Reykjavik, Iceland.
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.

Hongsheng Gui (H)

Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.

Rebecca Gutmann (R)

Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Christopher M Haggerty (CM)

Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.

Pim van der Harst (P)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.

Åsa K Hedman (ÅK)

Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.

Anna Helgadottir (A)

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

Hans Hillege (H)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Craig L Hyde (CL)

Pfizer Worldwide Research & Development, Cambridge, MA, USA.

Jaison Jacob (J)

Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

J Wouter Jukema (JW)

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Netherlands Heart Institute, Utrecht, The Netherlands.

Frederick Kamanu (F)

Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Isabella Kardys (I)

Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Maryam Kavousi (M)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Kay-Tee Khaw (KT)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Marcus E Kleber (ME)

Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.

Lars Køber (L)

Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Andrea Koekemoer (A)

Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Bill Kraus (B)

Duke Molecular Physiology Institute, Durham, NC, USA.

Karoline Kuchenbaecker (K)

UCL Genetics Institute, University College London, London, UK.
Division of Psychiatry, University College of London, London, UK.

Claudia Langenberg (C)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Lars Lind (L)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Cecilia M Lindgren (CM)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

Barry London (B)

Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.

Luca A Lotta (LA)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Ruth C Lovering (RC)

Institute of Cardiovascular Science, University College London, London, UK.

Jian'an Luan (J)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Patrik Magnusson (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Anubha Mahajan (A)

Genentech Inc., San Francisco, CA, USA.

Douglas Mann (D)

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Kenneth B Margulies (KB)

Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Nicholas A Marston (NA)

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Winfried März (W)

Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

John J V McMurray (JJV)

BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Olle Melander (O)

Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.

Giorgio Melloni (G)

Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Ify R Mordi (IR)

Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

Michael P Morley (MP)

Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Andrew D Morris (AD)

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Andrew P Morris (AP)

Department of Biostatistics, University of Liverpool, Liverpool, UK.
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

Alanna C Morrison (AC)

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Michael W Nagle (MW)

Pfizer Worldwide Research & Development, Cambridge, MA, USA.

Christopher P Nelson (CP)

Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Christopher Newton-Cheh (C)

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.

Alexander Niessner (A)

Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.

Teemu Niiranen (T)

Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Christoph Nowak (C)

Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.

Michelle L O'Donoghue (ML)

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Anjali T Owens (AT)

Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Colin N A Palmer (CNA)

Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

Guillaume Paré (G)

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Markus Perola (M)

National Institute for Health and Welfare, Helsinki, Finland.

Louis-Philippe Lemieux Perreault (LL)

Montreal Heart Institute, Montreal, Quebec, Canada.

Eliana Portilla-Fernandez (E)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.

Kenneth M Rice (KM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Paul M Ridker (PM)

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Simon P R Romaine (SPR)

Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Carolina Roselli (C)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Christian T Ruff (CT)

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Marc S Sabatine (MS)

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Perttu Salo (P)

Finnish Institute for Health and Welfare, Helsinki, Finland.

Veikko Salomaa (V)

Finnish Institute for Health and Welfare, Helsinki, Finland.

Jessica van Setten (J)

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

Alaa A Shalaby (AA)

Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA.

Diane T Smelser (DT)

Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.

Nicholas L Smith (NL)

Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA.

Kari Stefansson (K)

deCODE genetics/Amgen Inc., Reykjavik, Iceland.
Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland.

Steen Stender (S)

Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, Denmark.

David J Stott (DJ)

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Garðar Sveinbjörnsson (G)

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

Mari-Liis Tammesoo (ML)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Jean-Claude Tardif (JC)

Montreal Heart Institute, Montreal, Quebec, Canada.
Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.

Kent D Taylor (KD)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Maris Teder-Laving (M)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Alexander Teumer (A)

DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Guðmundur Thorgeirsson (G)

deCODE genetics/Amgen Inc., Reykjavik, Iceland.
Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland.

Unnur Thorsteinsdottir (U)

deCODE genetics/Amgen Inc., Reykjavik, Iceland.
Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland.

Christian Torp-Pedersen (C)

Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
Department of Health, Science and Technology, Aalborg University Hospital, Aalborg, Denmark.
Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.

Stella Trompet (S)

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Danny Tuckwell (D)

Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

Benoit Tyl (B)

Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France.

Andre G Uitterlinden (AG)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Felix Vaura (F)

Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Clinical Medicine, University of Turku, Turku, Finland.

Abirami Veluchamy (A)

Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

Peter M Visscher (PM)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Uwe Völker (U)

DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Adriaan A Voors (AA)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Xiaosong Wang (X)

Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Peter E Weeke (PE)

Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Raul Weiss (R)

Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA.

Harvey D White (HD)

Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.

Kerri L Wiggins (KL)

Department of Medicine, University of Washington, Seattle, WA, USA.

Heming Xing (H)

Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

Jian Yang (J)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Yifan Yang (Y)

Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Laura M Yerges-Armstrong (LM)

Human Genetics, GlaxoSmithKline, Collegeville, PA, USA.

Bing Yu (B)

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Faiez Zannad (F)

CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy, France.

Faye Zhao (F)

Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
Regeneron Genetics Center, Tarrytown, NY, USA.

Jemma B Wilk (JB)

Pfizer Worldwide Research & Development, Cambridge, MA, USA.

Hilma Holm (H)

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

Naveed Sattar (N)

BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Steven A Lubitz (SA)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

David E Lanfear (DE)

Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.

Svati Shah (S)

Duke Molecular Physiology Institute, Durham, NC, USA.
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Duke Clinical Research Institute, Durham, NC, USA.

Michael E Dunn (ME)

Regeneron Pharmaceuticals, Cardiovascular Research, Tarrytown, NY, USA.

Quinn S Wells (QS)

Division of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN, USA.

Folkert W Asselbergs (FW)

Health Data Research UK London, University College London, London, UK.
BHF Research Accelerator, University College London, London, UK.
Institute of Cardiovascular Science, University College London, London, UK.
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

Aroon D Hingorani (AD)

BHF Research Accelerator, University College London, London, UK.
Institute of Cardiovascular Science, University College London, London, UK.

Marie-Pierre Dubé (MP)

Montreal Heart Institute, Montreal, Quebec, Canada.
Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.

Nilesh J Samani (NJ)

Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Chim C Lang (CC)

Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

Thomas P Cappola (TP)

Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Patrick T Ellinor (PT)

Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

Ramachandran S Vasan (RS)

National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA.

J Gustav Smith (JG)

Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.
The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

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