Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species.
AVPR1a
Amygdala
Great apes
Lateral septum
OXTR
Primate
Social behavior
Ventral pallidum
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
02
03
2021
accepted:
23
08
2021
pubmed:
6
9
2021
medline:
18
5
2022
entrez:
5
9
2021
Statut:
ppublish
Résumé
Despite our close genetic relationship with chimpanzees, there are notable differences between chimpanzee and human social behavior. Oxytocin and vasopressin are neuropeptides involved in regulating social behavior across vertebrate taxa, including pair bonding, social communication, and aggression, yet little is known about the neuroanatomy of these systems in primates, particularly in great apes. Here, we used receptor autoradiography to localize oxytocin and vasopressin V1a receptors, OXTR and AVPR1a respectively, in seven chimpanzee brains. OXTR binding was detected in the lateral septum, hypothalamus, medial amygdala, and substantia nigra. AVPR1a binding was observed in the cortex, lateral septum, hypothalamus, mammillary body, entire amygdala, hilus of the dentate gyrus, and substantia nigra. Chimpanzee OXTR/AVPR1a receptor distribution is compared to previous studies in several other primate species. One notable difference is the lack of OXTR in reward regions such as the ventral pallidum and nucleus accumbens in chimpanzees, whereas OXTR is found in these regions in humans. Our results suggest that in chimpanzees, like in most other anthropoid primates studied to date, OXTR has a more restricted distribution than AVPR1a, while in humans the reverse pattern has been reported. Altogether, our study provides a neuroanatomical basis for understanding the function of the oxytocin and vasopressin systems in chimpanzees.
Identifiants
pubmed: 34482474
doi: 10.1007/s00429-021-02369-7
pii: 10.1007/s00429-021-02369-7
pmc: PMC8897511
mid: NIHMS1753562
doi:
Substances chimiques
Receptors, Oxytocin
0
Receptors, Vasopressin
0
Oxytocin
50-56-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1907-1919Subventions
Organisme : NINDS NIH HHS
ID : R24 NS092988
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIH HHS
ID : NS092988
Pays : United States
Organisme : NIH HHS
ID : 1P50MH100023
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH100023
Pays : United States
Organisme : NIH HHS
ID : P51OD11132
Pays : United States
Organisme : Leakey Foundation
ID : 38217
Organisme : NIH HHS
ID : 1P50MH100023
Pays : United States
Organisme : NIH HHS
ID : P51OD11132
Pays : United States
Organisme : NIH HHS
ID : NS092988
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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