Paracetamol toxicity in mild overdose in combination with opioids: A retrospective observational study.
clinical toxicology
opioids
overdose and poisoning
toxicity
Journal
British journal of clinical pharmacology
ISSN: 1365-2125
Titre abrégé: Br J Clin Pharmacol
Pays: England
ID NLM: 7503323
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
15
08
2021
received:
05
03
2020
accepted:
17
08
2021
pubmed:
7
9
2021
medline:
27
4
2022
entrez:
6
9
2021
Statut:
ppublish
Résumé
Toxicity in paracetamol overdose with opioid co-ingestion is poorly understood. We compared outcomes in both paracetamol-only and paracetamol-opioid overdoses to determine whether toxicity differed significantly between the groups, and to assess the utility of the ratio of measured plasma paracetamol concentration relative to the 4-hour nomogram-adjusted level (APAP We conducted a retrospective observational study of all patients (n = 1159) presenting to 2 large UK hospitals between 2005 and 2013 with acute single-dose ingestion paracetamol overdose, with (n = 221) or without (n = 938) opioid co-ingestion. Adverse outcomes included biomarkers of hepatotoxicity and the need for extended treatment. Several outcomes were assessed in relation to the APAP Median ingested dose of paracetamol was low in both groups (10 g). Statistical comparison of the median APAP Our study does not support a change in current clinical practise beyond standard testing at 4 hours or longer post ingestion for mixed low dose paracetamol-opioid overdose.
Substances chimiques
Analgesics, Non-Narcotic
0
Analgesics, Opioid
0
Acetaminophen
362O9ITL9D
Alanine Transaminase
EC 2.6.1.2
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1258-1267Informations de copyright
© 2021 British Pharmacological Society.
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