Renal Hemodynamics and Renin-Angiotensin-Aldosterone System Profiles in Patients With Heart Failure.
Heart failure
renal hemodynamics
renin angiotensin aldosterone system
Journal
Journal of cardiac failure
ISSN: 1532-8414
Titre abrégé: J Card Fail
Pays: United States
ID NLM: 9442138
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
29
04
2021
revised:
19
07
2021
accepted:
17
08
2021
pubmed:
7
9
2021
medline:
4
5
2022
entrez:
6
9
2021
Statut:
ppublish
Résumé
Understanding cardiorenal pathophysiology in heart failure (HF) is of clinical importance. We sought to characterize the renal hemodynamic function and the transrenal gradient of the renin-angiotensin-aldosterone system (RAAS) markers in patients with HF and in controls without HF. In this post hoc analysis, the glomerular filtration rate (GFR The concentrations of PRA, aldosterone and ACE were higher in the renal vein vs the artery in patients with HF vs patients without HF (P < 0.01). In patients with HF, a greater ACE gradient was associated with greater renal vascular resistance (r = 0.42; P 0.007) and greater arteriolar resistances (R A larger transrenal RAAS marker gradient in patients with HF suggests a renal origin for neurohormonal activation associated with a vasoconstrictive renal profile.
Identifiants
pubmed: 34487814
pii: S1071-9164(21)00356-0
doi: 10.1016/j.cardfail.2021.08.015
pii:
doi:
Substances chimiques
Biomarkers
0
Nitroprusside
169D1260KM
Dobutamine
3S12J47372
Aldosterone
4964P6T9RB
Renin
EC 3.4.23.15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
385-393Informations de copyright
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