Evolution of cytokine production capacity in ancient and modern European populations.
adaptation
disease
evolution
genetics
genomics
human
immune system
immunology
inflammation
neolithic
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
07 09 2021
07 09 2021
Historique:
received:
17
11
2020
accepted:
30
06
2021
entrez:
7
9
2021
pubmed:
8
9
2021
medline:
25
2
2023
Statut:
epublish
Résumé
As our ancestors migrated throughout different continents, natural selection increased the presence of alleles advantageous in the new environments. Heritable variations that alter the susceptibility to diseases vary with the historical period, the virulence of the infections, and their geographical spread. In this study we built polygenic scores for heritable traits that influence the genetic adaptation in the production of cytokines and immune-mediated disorders, including infectious, inflammatory, and autoimmune diseases, and applied them to the genomes of several ancient European populations. We observed that the advent of the Neolithic was a turning point for immune-mediated traits in Europeans, favoring those alleles linked with the development of tolerance against intracellular pathogens and promoting inflammatory responses against extracellular microbes. These evolutionary patterns are also associated with an increased presence of traits related to inflammatory and auto-immune diseases.
Identifiants
pubmed: 34488939
doi: 10.7554/eLife.64971
pii: 64971
pmc: PMC8423439
doi:
pii:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Domínguez-Andrés et al.
Déclaration de conflit d'intérêts
JD, YK, OB, MJ, CX, MJ, JB, LJ, YL, MN No competing interests declared, JV Senior editor, eLife
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