Infection-induced type I interferons critically modulate the homeostasis and function of CD8
Animals
Antigens, Ly
/ genetics
CD4-Positive T-Lymphocytes
/ immunology
CD5 Antigens
/ genetics
CD8 Antigens
/ genetics
CD8-Positive T-Lymphocytes
/ immunology
Cell Differentiation
Female
Gene Expression Profiling
Gene Expression Regulation
Homeostasis
/ genetics
Immunologic Memory
/ genetics
Interferon-alpha
/ genetics
Interferon-gamma
/ genetics
Interleukin-7
/ genetics
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Receptors, Antigen, T-Cell
/ genetics
Signal Transduction
West Nile Fever
/ genetics
West Nile virus
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 09 2021
06 09 2021
Historique:
received:
08
02
2021
accepted:
21
08
2021
entrez:
7
9
2021
pubmed:
8
9
2021
medline:
6
10
2021
Statut:
epublish
Résumé
Naïve T (Tn) cells require two homeostatic signals for long-term survival: tonic T cell receptor:self-peptide-MHC contact and IL-7 stimulation. However, how microbial exposure impacts Tn homeostasis is still unclear. Here we show that infections can lead to the expansion of a subpopulation of long-lived, Ly6C
Identifiants
pubmed: 34489451
doi: 10.1038/s41467-021-25645-w
pii: 10.1038/s41467-021-25645-w
pmc: PMC8421345
doi:
Substances chimiques
Antigens, Ly
0
CD5 Antigens
0
CD8 Antigens
0
Cd5 protein, mouse
0
Interferon-alpha
0
Interleukin-7
0
Ly-6C antigen, mouse
0
Receptors, Antigen, T-Cell
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5303Subventions
Organisme : NIA NIH HHS
ID : R01 AG020719
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048021
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG020719
Pays : United States
Informations de copyright
© 2021. The Author(s).
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