Prognostic value of polygenic risk scores for adults with psychosis.

Adult Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Middle Aged Multifactorial Inheritance / genetics Prognosis Psychotic Disorders / genetics Risk Factors Schizophrenia / genetics

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
09 2021
Historique:
received: 06 03 2021
accepted: 22 07 2021
pubmed: 8 9 2021
medline: 9 10 2021
entrez: 7 9 2021
Statut: ppublish

Résumé

Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level, and the aim is to use them as biomarkers of disease and poor outcomes in real-world clinical practice. To date, few studies have assessed the prognostic value of PRS relative to standards of care. Schizophrenia (SCZ), the archetypal psychotic illness, is an ideal test case for this because the predictive power of the SCZ PRS exceeds that of most other common diseases. Here, we analyzed clinical and genetic data from two multi-ethnic cohorts totaling 8,541 adults with SCZ and related psychotic disorders, to assess whether the SCZ PRS improves the prediction of poor outcomes relative to clinical features captured in a standard psychiatric interview. For all outcomes investigated, the SCZ PRS did not improve the performance of predictive models, an observation that was generally robust to divergent case ascertainment strategies and the ancestral background of the study participants.

Identifiants

DOI: 10.1038/s41591-021-01475-7 PMID: 34489608 PMC: PMC8446329
pubmed: 34489608
doi: 10.1038/s41591-021-01475-7
pii: 10.1038/s41591-021-01475-7
pmc: PMC8446329
mid: NIHMS1732074
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1576-1581

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH104964
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085548
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123451
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121922
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121923
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Isotta Landi (I)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. isotta.landi2@mssm.edu.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. isotta.landi2@mssm.edu.
Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. isotta.landi2@mssm.edu.
Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA. isotta.landi2@mssm.edu.
ORCID: 0000-0003-4212-4709

Deepak A Kaji (DA)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Liam Cotter (L)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Tielman Van Vleck (T)

Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-4488-8174

Gillian Belbin (G)

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Michael Preuss (M)

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-5266-8465

Ruth J F Loos (RJF)

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8532-5087

Eimear Kenny (E)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Benjamin S Glicksberg (BS)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-4515-8090

Noam D Beckmann (ND)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Paul O'Reilly (P)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-7515-0845

Eric E Schadt (EE)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sema4, Stamford, CT, USA.
ORCID: 0000-0002-7892-8808

Eric D Achtyes (ED)

Cherry Health, Grand Rapids, MI, USA.
Michigan State University College of Human Medicine, Grand Rapids, MI, USA.
ORCID: 0000-0001-8939-1535

Peter F Buckley (PF)

School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Douglas Lehrer (D)

Department of Psychiatry, Wright State University, Dayton, OH, USA.

Dolores P Malaspina (DP)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Steven A McCarroll (SA)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Genetics, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-6954-8184

Mark H Rapaport (MH)

Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Ayman H Fanous (AH)

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
VA New York Harbor Healthcare System, Brooklyn, NY, USA.

Michele T Pato (MT)

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Carlos N Pato (CN)

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Tim B Bigdeli (TB)

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
VA New York Harbor Healthcare System, Brooklyn, NY, USA.

Girish N Nadkarni (GN)

Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Alexander W Charney (AW)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.charney@mssm.edu.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.charney@mssm.edu.
Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.charney@mssm.edu.
ORCID: 0000-0001-8135-6858

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Diagnostic › Pronostic › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Prognostic value of polygenic risk scores for...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Prognostic value of polygenic risk scores for...