In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome.
Adenosine Diphosphate
/ metabolism
Adenosine Triphosphate
/ metabolism
Adolescent
Case-Control Studies
Child
Cross-Sectional Studies
Humans
Insulin Resistance
Klinefelter Syndrome
/ metabolism
Magnetic Resonance Spectroscopy
Male
Mitochondria
Mitochondria, Muscle
/ metabolism
Muscle, Skeletal
/ metabolism
Phosphocreatine
/ metabolism
Testosterone
/ deficiency
muscle
skeletal
testosterone
Journal
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
ISSN: 1708-8267
Titre abrégé: J Investig Med
Pays: England
ID NLM: 9501229
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
accepted:
13
08
2021
pubmed:
9
9
2021
medline:
29
3
2022
entrez:
8
9
2021
Statut:
ppublish
Résumé
Klinefelter syndrome (XXY) occurs in 1 in 600 males, resulting in testosterone deficiency and a high prevalence of insulin resistance. Testosterone deficiency in men is a known cause of insulin resistance, and mitochondrial dysfunction is hypothesized to mediate this relationship. The aim of this cross-sectional study was to evaluate muscle mitochondrial function in XXY compared with male controls. Twenty-seven boys with XXY (age 14.7±1.8 years) were compared with 87 controls (age 16.9±0.9). In-vivo calf muscle mitochondrial function was assessed via phosphorus magnetic resonance spectroscopy (
Identifiants
pubmed: 34493629
pii: jim-2021-001966
doi: 10.1136/jim-2021-001966
pmc: PMC8712372
mid: NIHMS1736348
doi:
Substances chimiques
Phosphocreatine
020IUV4N33
Testosterone
3XMK78S47O
Adenosine Diphosphate
61D2G4IYVH
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-107Subventions
Organisme : NIDDK NIH HHS
ID : T32 DK063687
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NIH HHS
ID : S10 OD018435
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002535
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK088971
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116073
Pays : United States
Organisme : NICHD NIH HHS
ID : K23 HD092588
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL145076
Pays : United States
Organisme : NCRR NIH HHS
ID : K23 RR020038
Pays : United States
Informations de copyright
© American Federation for Medical Research 2022. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Pediatr Exerc Sci. 2015 May;27(2):262-7
pubmed: 25902553
Int J Med Sci. 2018 Jan 1;15(1):31-35
pubmed: 29333085
Hum Pathol. 1984 Feb;15(2):181-90
pubmed: 6141991
Expert Rev Endocrinol Metab. 2019 Mar;14(2):145-152
pubmed: 30793993
J Clin Endocrinol Metab. 2010 Sep;95(9):E69-74
pubmed: 20554709
Eur J Endocrinol. 2016 Jul;175(1):R27-40
pubmed: 26850445
J Multidiscip Healthc. 2015 Jul 17;8:323-34
pubmed: 26229481
J Endocrinol Invest. 2017 Jul;40(7):705-712
pubmed: 28258556
Reprod Med Biol. 2018 Dec 08;18(2):140-150
pubmed: 30996677
Med Sci Sports Exerc. 2014 Oct;46(10):2030-6
pubmed: 24576856
F1000Res. 2019 Jan 28;8:
pubmed: 30755791
Diabetes Care. 2014 Dec;37(12):3336-44
pubmed: 25414389
Arch Pathol Lab Med. 1982 May;106(5):228-30
pubmed: 6896133
Metabolism. 2019 Jun;95:21-26
pubmed: 30878494
Curr Opin Endocrinol Diabetes Obes. 2019 Feb;26(1):60-65
pubmed: 30507702
Horm Mol Biol Clin Investig. 2011 Oct 1;8(1):431-44
pubmed: 25961343
J Clin Endocrinol Metab. 2016 Feb;101(2):686-95
pubmed: 26672636
Endocrine. 2018 Aug;61(2):194-203
pubmed: 29572708
Adv Pediatr. 2016 Aug;63(1):15-46
pubmed: 27426894
Int J Endocrinol. 2019 Dec 1;2019:8586167
pubmed: 31885562
Diabet Med. 2017 Oct;34(10):1392-1399
pubmed: 28636758
J Clin Endocrinol Metab. 2017 May 1;102(5):1652-1660
pubmed: 28204552