Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma.
Adolescent
Adult
Animals
Anti-Asthmatic Agents
/ therapeutic use
Antigens, Dermatophagoides
/ toxicity
Asthma
/ drug therapy
Bile Acids and Salts
/ metabolism
Diet, High-Fat
/ adverse effects
Drug Evaluation, Preclinical
Fatty Acids
/ chemistry
Female
Forced Expiratory Volume
Glycocholic Acid
/ blood
Humans
Liver
/ drug effects
Lung
/ physiopathology
Male
Mice
Mice, Inbred C57BL
Middle Aged
Nitro Compounds
/ therapeutic use
Obesity
/ complications
Oleic Acids
/ therapeutic use
Respiratory Hypersensitivity
/ chemically induced
Thinness
Ursodeoxycholic Acid
/ analogs & derivatives
Vital Capacity
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 09 2021
07 09 2021
Historique:
received:
25
06
2021
accepted:
10
08
2021
entrez:
8
9
2021
pubmed:
9
9
2021
medline:
17
11
2021
Statut:
epublish
Résumé
Bile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute to lung pathophysiology. We also test the therapeutic potential of nitro-oleic acid (NO
Identifiants
pubmed: 34493738
doi: 10.1038/s41598-021-96471-9
pii: 10.1038/s41598-021-96471-9
pmc: PMC8423735
doi:
Substances chimiques
Anti-Asthmatic Agents
0
Antigens, Dermatophagoides
0
Bile Acids and Salts
0
Fatty Acids
0
Nitro Compounds
0
Oleic Acids
0
CXA-10
1N19AGY57Y
glycoursodeoxycholic acid
64480-66-6
Ursodeoxycholic Acid
724L30Y2QR
Glycocholic Acid
G59NX3I3RT
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17788Subventions
Organisme : NIH HHS
ID : F32AI085633
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132550
Pays : United States
Organisme : NIH HHS
ID : R01HL132550
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM133332
Pays : United States
Organisme : NIH HHS
ID : S10 OD023402
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146445
Pays : United States
Organisme : NIH HHS
ID : R21AI122071
Pays : United States
Organisme : NIH HHS
ID : R01HL146445
Pays : United States
Organisme : NIH HHS
ID : F31HL142171
Pays : United States
Informations de copyright
© 2021. The Author(s).
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