Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.

Chromosome Mapping DNA / metabolism DNA Methylation / genetics Epigenesis, Genetic / genetics Gene Expression Regulation / genetics Genetic Predisposition to Disease / genetics Genome-Wide Association Study Humans Multifactorial Inheritance / genetics Polymorphism, Single Nucleotide / genetics Quantitative Trait Loci / genetics Quantitative Trait, Heritable Transcriptome / genetics

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
09 2021
Historique:
received: 13 10 2020
accepted: 12 07 2021
entrez: 8 9 2021
pubmed: 9 9 2021
medline: 15 10 2021
Statut: ppublish

Résumé

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriched for genomic annotations and complex traits. Shared genetic variants are associated with both DNAm levels and complex diseases, but only in a minority of cases do these associations reflect causal relationships from DNAm to trait or vice versa, indicating a more complex genotype-phenotype map than previously anticipated.

Identifiants

DOI: 10.1038/s41588-021-00923-x PMID: 34493871 PMC: PMC7612069
pubmed: 34493871
doi: 10.1038/s41588-021-00923-x
pii: 10.1038/s41588-021-00923-x
pmc: PMC7612069
mid: EMS131971
doi:

Substances chimiques

DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1311-1321

Subventions

Organisme : ZonMw
ID : ZONMW_529051021
Pays : Netherlands
Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L501529/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_21038
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204979/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008924/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00006/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N024397/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CS/15/6/31468
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CS/13/1/30327
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001357
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K013807/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Motor Neurone Disease Association
ID : ALCHALABI-TALBOT/APR14/926-794
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1002190
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600974
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R024804/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CS/16/4/32482
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A19169
Pays : United Kingdom
Organisme : Motor Neurone Disease Association
ID : ALCHALABI-DOBSON/APR14/829-791
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/4
Pays : United Kingdom
Organisme : Cancer Research UK (CRUK)
ID : C18281/A191169
Organisme : Wellcome Trust
ID : 208806
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/8
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S020845/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 208806/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R005176/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204979
Pays : United Kingdom

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Josine L Min (JL)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. josine.min@bristol.ac.uk.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. josine.min@bristol.ac.uk.
ORCID: 0000-0003-4456-9824

Gibran Hemani (G)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0003-0920-1055

Eilis Hannon (E)

University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.
ORCID: 0000-0001-6840-072X

Koen F Dekkers (KF)

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.

Juan Castillo-Fernandez (J)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
ORCID: 0000-0002-0034-8029

René Luijk (R)

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.

Elena Carnero-Montoro (E)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Pfizer-University of Granada-Andalusian Government Center for Genomics and Oncological Research, Granada, Spain.

Daniel J Lawson (DJ)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-5311-6213

Kimberley Burrows (K)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-3208-0389

Matthew Suderman (M)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Andrew D Bretherick (AD)

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-9258-3140

Tom G Richardson (TG)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-7918-2040

Johanna Klughammer (J)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

Valentina Iotchkova (V)

MRC Weatherall Institute of Molecular Medicine, Oxford, UK.
ORCID: 0000-0001-5057-0210

Gemma Sharp (G)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0003-2906-4035

Ahmad Al Khleifat (A)

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.
ORCID: 0000-0002-7406-9831

Aleksey Shatunov (A)

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.

Alfredo Iacoangeli (A)

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Department of Biostatistics and Health Informatics, King's College London, London, UK.

Wendy L McArdle (WL)

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-0605-5403

Karen M Ho (KM)

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Ashish Kumar (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Chronic Disease Epidemiology unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Cilla Söderhäll (C)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Carolina Soriano-Tárraga (C)

Neurology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.
ORCID: 0000-0002-5635-273X

Eva Giralt-Steinhauer (E)

Neurology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.

Nabila Kazmi (N)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Dan Mason (D)

Bradford Institute for Health Research, Bradford, UK.
ORCID: 0000-0002-0026-9216

Allan F McRae (AF)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
ORCID: 0000-0001-5286-5485

David L Corcoran (DL)

Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
ORCID: 0000-0001-7460-9247

Karen Sugden (K)

Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.

Silva Kasela (S)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0003-4362-0034

Alexia Cardona (A)

MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Department of Genetics, University of Cambridge, Cambridge, UK.

Felix R Day (FR)

MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-3789-7651

Giovanni Cugliari (G)

Department of Medical Sciences, University of Turin, Turin, Italy.
Italian Institute for Genomic Medicine, Turin, Italy.

Clara Viberti (C)

Department of Medical Sciences, University of Turin, Turin, Italy.
Italian Institute for Genomic Medicine, Turin, Italy.

Simonetta Guarrera (S)

Department of Medical Sciences, University of Turin, Turin, Italy.
Italian Institute for Genomic Medicine, Turin, Italy.
ORCID: 0000-0003-4400-1817

Michael Lerro (M)

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Richa Gupta (R)

Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0001-7700-5828

Sailalitha Bollepalli (S)

Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-8773-7149

Pooja Mandaviya (P)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

Yanni Zeng (Y)

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
ORCID: 0000-0003-3507-5611

Toni-Kim Clarke (TK)

Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.

Rosie M Walker (RM)

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-1060-4479

Vanessa Schmoll (V)

Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.

Darina Czamara (D)

Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
ORCID: 0000-0001-7381-904X

Carlos Ruiz-Arenas (C)

ISGlobal, Barcelona Global Health Institute, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Madrid, Spain.
ORCID: 0000-0002-6014-3498

Faisal I Rezwan (FI)

Department of Computer Science, Aberystwyth University, Aberystwyth, UK.
ORCID: 0000-0001-9921-222X

Riccardo E Marioni (RE)

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.

Tian Lin (T)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
ORCID: 0000-0002-5981-1911

Yvonne Awaloff (Y)

Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.

Marine Germain (M)

INSERM UMR_S 1219, Bordeaux Population Health Center, University of Bordeaux, Bordeaux, France.

Dylan Aïssi (D)

Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
ORCID: 0000-0002-5858-6468

Ramona Zwamborn (R)

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

Kristel van Eijk (K)

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

Annelot Dekker (A)

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

Jenny van Dongen (J)

Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
ORCID: 0000-0003-2063-8741

Jouke-Jan Hottenga (JJ)

Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
ORCID: 0000-0002-5668-2368

Gonneke Willemsen (G)

Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Cheng-Jian Xu (CJ)

University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute Groningen, Groningen, the Netherlands.
CiiM and TWINCORE, Hannover Medical School and Helmholtz Centre for Infection Research, Hannover, Germany.

Guillermo Barturen (G)

Pfizer-University of Granada-Andalusian Government Center for Genomics and Oncological Research, Granada, Spain.
ORCID: 0000-0003-2103-1028

Francesc Català-Moll (F)

Chromatin and Disease Group, Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, Barcelona, Spain.

Martin Kerick (M)

Instituto de Parasitología y Biomedicina López Neyra, CSIC, Granada, Spain.
ORCID: 0000-0002-6298-4514

Carol Wang (C)

School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia.
ORCID: 0000-0002-4301-3974

Phillip Melton (P)

Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia.
School of Global Population Health, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia.
School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, Australia.
ORCID: 0000-0003-4026-2964

Hannah R Elliott (HR)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-1500-3533

Jean Shin (J)

The Hospital for Sick Children, University of Toronto, Toronto, Canada.
ORCID: 0000-0001-7353-5178

Manon Bernard (M)

The Hospital for Sick Children, University of Toronto, Toronto, Canada.

Idil Yet (I)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Department of Bioinformatics, Institute of Health Sciences, Hacettepe University, Ankara, Turkey.
ORCID: 0000-0002-1227-0716

Melissa Smart (M)

Institute for Social and Economic Research, University of Essex, Colchester, UK.

Tyler Gorrie-Stone (T)

School of Life Sciences, University of Essex, Colchester, UK.
ORCID: 0000-0002-1817-1495

Chris Shaw (C)

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Department of Neurology, King's College Hospital, London, UK.

Ammar Al Chalabi (A)

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Department of Neurology, King's College Hospital, London, UK.
United Kingdom Dementia Research Institute, King's College London, London, UK.
ORCID: 0000-0002-4924-7712

Susan M Ring (SM)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0003-3103-9330

Göran Pershagen (G)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Erik Melén (E)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-8248-0663

Jordi Jiménez-Conde (J)

Neurology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.

Jaume Roquer (J)

Neurology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.
ORCID: 0000-0001-5992-2606

Deborah A Lawlor (DA)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-6793-2262

John Wright (J)

Bradford Institute for Health Research, Bradford, UK.

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Brisbane, Australia.
ORCID: 0000-0003-4069-8020

Grant W Montgomery (GW)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
ORCID: 0000-0002-4140-8139

Terrie E Moffitt (TE)

Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC, USA.
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Richie Poulton (R)

Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
ORCID: 0000-0002-1052-4583

Tõnu Esko (T)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.

Lili Milani (L)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-5323-3102

Andres Metspalu (A)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-3718-796X

John R B Perry (JRB)

MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-6483-3771

Ken K Ong (KK)

MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-4689-7530

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-1422-2993

Giuseppe Matullo (G)

Department of Medical Sciences, University of Turin, Turin, Italy.
Italian Institute for Genomic Medicine, Turin, Italy.

Carlotta Sacerdote (C)

Italian Institute for Genomic Medicine, Turin, Italy.
Piemonte Centre for Cancer Prevention, Turin, Italy.

Salvatore Panico (S)

Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy.

Avshalom Caspi (A)

Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC, USA.
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Louise Arseneault (L)

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
ORCID: 0000-0002-2938-2191

France Gagnon (F)

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Miina Ollikainen (M)

Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0003-3661-7400

Jaakko Kaprio (J)

Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-3716-2455

Janine F Felix (JF)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
ORCID: 0000-0002-9801-5774

Fernando Rivadeneira (F)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0001-9435-9441

Henning Tiemeier (H)

Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands.
Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, MA, USA.
ORCID: 0000-0002-4395-1397

Marinus H van IJzendoorn (MH)

Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Department of Clinical, Educational and Health Psychology, Division on Psychology and Language Sciences, Faculty of Brain Sciences, University College London, London, UK.
ORCID: 0000-0003-1144-454X

André G Uitterlinden (AG)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0002-7276-3387

Vincent W V Jaddoe (VWV)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
ORCID: 0000-0003-2939-0041

Chris Haley (C)

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Andrew M McIntosh (AM)

Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-0198-4588

Kathryn L Evans (KL)

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-7884-5877

Alison Murray (A)

Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
ORCID: 0000-0003-4915-4847

Katri Räikkönen (K)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Jari Lahti (J)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-4310-5297

Ellen A Nohr (EA)

Research Unit for Gynaecology and Obstetrics, Institute of Clinical research, University of Southern Denmark, Odense, Denmark.
Centre of Women's, Family and Child Health, University of South-Eastern Norway, Kongsberg, Norway.

Thorkild I A Sørensen (TIA)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Public Health (Section of Epidemiology), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-4821-430X

Torben Hansen (T)

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0001-8748-3831

Camilla S Morgen (CS)

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Elisabeth B Binder (EB)

Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
ORCID: 0000-0001-7088-6618

Susanne Lucae (S)

Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.

Juan Ramon Gonzalez (JR)

ISGlobal, Barcelona Global Health Institute, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Madrid, Spain.
ORCID: 0000-0003-3267-2146

Mariona Bustamante (M)

ISGlobal, Barcelona Global Health Institute, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Madrid, Spain.
Center for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
ORCID: 0000-0003-0127-2860

Jordi Sunyer (J)

ISGlobal, Barcelona Global Health Institute, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
CIBER Epidemiología y Salud Pública, Madrid, Spain.
Hospital del Mar Medical Research Institute, Barcelona, Spain.

John W Holloway (JW)

Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
ORCID: 0000-0001-9998-0464

Wilfried Karmaus (W)

Division of Epidemiology, Biostatistics, and Environmental Health Sciences, School of Public Health, University of Memphis, Memphis, TN, USA.

Hongmei Zhang (H)

Division of Epidemiology, Biostatistics, and Environmental Health Sciences, School of Public Health, University of Memphis, Memphis, TN, USA.

Ian J Deary (IJ)

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.

Naomi R Wray (NR)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
Queensland Brain Institute, University of Queensland, Brisbane, Australia.
ORCID: 0000-0001-7421-3357

John M Starr (JM)

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.

Marian Beekman (M)

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
ORCID: 0000-0003-0585-6206

Diana van Heemst (D)

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.

P Eline Slagboom (PE)

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
ORCID: 0000-0002-2875-4723

Pierre-Emmanuel Morange (PE)

C2VN, Aix-Marseille University, INSERM, INRAE, Marseille, France.
ORCID: 0000-0002-9065-722X

David-Alexandre Trégouët (DA)

INSERM UMR_S 1219, Bordeaux Population Health Center, University of Bordeaux, Bordeaux, France.

Jan H Veldink (JH)

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
ORCID: 0000-0001-5572-9657

Gareth E Davies (GE)

Avera Institute for Human Genetics, Sioux Falls, SD, USA.

Eco J C de Geus (EJC)

Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Dorret I Boomsma (DI)

Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
ORCID: 0000-0002-7099-7972

Judith M Vonk (JM)

University of Groningen, University Medical Center Groningen, Department of Epidemiology, GRIAC Research Institute Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-7531-4547

Bert Brunekreef (B)

Institute for Risk Assessment Sciences, Universiteit Utrecht, Utrecht, the Netherlands.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.

Gerard H Koppelman (GH)

University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-8567-3252

Marta E Alarcón-Riquelme (ME)

Pfizer-University of Granada-Andalusian Government Center for Genomics and Oncological Research, Granada, Spain.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-7632-4154

Rae-Chi Huang (RC)

Telethon Kids Institute, University of Western Australia, Perth, Australia.
ORCID: 0000-0002-8464-6639

Craig E Pennell (CE)

School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia.
ORCID: 0000-0002-0937-6165

Joyce van Meurs (J)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

M Arfan Ikram (MA)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
ORCID: 0000-0003-0372-8585

Alun D Hughes (AD)

UCL Institute of Cardiovascular Science, London, UK.
ORCID: 0000-0001-5432-5271

Therese Tillin (T)

UCL Institute of Cardiovascular Science, London, UK.

Nish Chaturvedi (N)

UCL Institute of Cardiovascular Science, London, UK.

Zdenka Pausova (Z)

The Hospital for Sick Children, University of Toronto, Toronto, Canada.
ORCID: 0000-0002-7784-1380

Tomas Paus (T)

Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada.
ORCID: 0000-0003-1495-9338

Timothy D Spector (TD)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
ORCID: 0000-0002-9795-0365

Meena Kumari (M)

Institute for Social and Economic Research, University of Essex, Colchester, UK.

Leonard C Schalkwyk (LC)

School of Life Sciences, University of Essex, Colchester, UK.
ORCID: 0000-0001-7030-5756

Peter M Visscher (PM)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
Queensland Brain Institute, University of Queensland, Brisbane, Australia.
ORCID: 0000-0002-2143-8760

George Davey Smith (G)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-1407-8314

Christoph Bock (C)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Institute of Artificial Intelligence and Decision Support, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0001-6091-3088

Tom R Gaunt (TR)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0003-0924-3247

Jordana T Bell (JT)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
ORCID: 0000-0002-3858-5986

Bastiaan T Heijmans (BT)

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
ORCID: 0000-0001-5918-0534

Jonathan Mill (J)

University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.
ORCID: 0000-0003-1115-3224

Caroline L Relton (CL)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Cartographie chromosomique › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Caractère quantitatif héréditaire › Genomic and phenotypic insights from an atlas...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Genomic and phenotypic insights from an atlas...