Diabetes concomitant to aortic stenosis is associated with increased expression of NF-κB and more pronounced valve calcification.
Aged
Aortic Valve
/ metabolism
Aortic Valve Stenosis
/ complications
Bone Morphogenetic Protein 2
/ metabolism
Calcinosis
/ etiology
Case-Control Studies
Cells, Cultured
Diabetes Mellitus, Type 2
/ complications
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique, Indirect
Humans
Male
Middle Aged
NF-kappa B
/ metabolism
Real-Time Polymerase Chain Reaction
Aortic stenosis
Bone morphogenetic protein 2
Coagulation factors
Diabetes mellitus
Inflammation
NF-κB
Oxidative stress
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
03
02
2021
accepted:
26
05
2021
pubmed:
9
9
2021
medline:
26
3
2022
entrez:
8
9
2021
Statut:
ppublish
Résumé
Type 2 diabetes has been demonstrated to predispose to aortic valve calcification. We investigated whether type 2 diabetes concomitant to aortic stenosis (AS) enhances valvular inflammation and coagulation activation via upregulated expression of NF-κB, with subsequent increased expression of bone morphogenetic protein 2 (BMP-2). In this case-control study, 50 individuals with severe isolated AS and concomitant type 2 diabetes were compared with a control group of 100 individuals without diabetes. The median (IQR) duration of diabetes since diagnosis was 11 (7-18) years, and 36 (72%) individuals had HbA Diabetic compared with non-diabetic individuals displayed enhanced valvular expression of NF-κB, BMP-2, FII and FXa (all p ≤ 0.001). Moreover, the expression of NF-κB and BMP-2 positively correlated with amounts of valvular FII and FXa. Only in diabetic participants, valvular NF-κB expression was strongly associated with serum levels of HbA Type 2 diabetes enhances in loco inflammation and coagulation activation within stenotic valve leaflets. Increased valvular expression of NF-κB in diabetic individuals is associated not only with serum HbA
Identifiants
pubmed: 34494136
doi: 10.1007/s00125-021-05545-w
pii: 10.1007/s00125-021-05545-w
pmc: PMC8494674
doi:
Substances chimiques
BMP2 protein, human
0
Bone Morphogenetic Protein 2
0
NF-kappa B
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2562-2574Informations de copyright
© 2021. The Author(s).
Références
J Am Heart Assoc. 2017 May 5;6(5):
pubmed: 28476875
J Am Coll Cardiol. 2006 Feb 21;47(4):850-5
pubmed: 16487855
Diabetes Care. 2014 Jan;37 Suppl 1:S81-90
pubmed: 24357215
Semin Immunopathol. 2012 Jan;34(1):133-49
pubmed: 21971685
Circ Cardiovasc Imaging. 2018 Mar;11(3):e007146
pubmed: 29555836
PLoS One. 2014 Dec 09;9(12):e114429
pubmed: 25490770
Circ Res. 2011 May 27;108(11):1392-412
pubmed: 21617136
J Fluoresc. 2015 Nov;25(6):1721-6
pubmed: 26410776
Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):187-93
pubmed: 17975118
Thromb Haemost. 2011 Feb;105(2):254-60
pubmed: 21057695
J Mol Cell Cardiol. 2014 Jul;72:146-56
pubmed: 24631773
J Am Coll Cardiol. 2015 Aug 4;66(5):561-77
pubmed: 26227196
Circulation. 2018 Aug 7;138(6):590-599
pubmed: 29487139
Diab Vasc Dis Res. 2019 Jul;16(4):310-323
pubmed: 30623669
Thromb Haemost. 2015 Aug;114(2):217-27
pubmed: 25809537
Cardiovasc Diabetol. 2020 Jun 17;19(1):92
pubmed: 32552684
Ann Thorac Surg. 2018 Apr;105(4):1137-1143
pubmed: 29394992
Am J Cardiol. 2001 Sep 15;88(6):693-5
pubmed: 11564402
Trends Mol Med. 2008 Oct;14(10):429-40
pubmed: 18774340
Circulation. 2021 Feb 2;143(5):e72-e227
pubmed: 33332150
Exp Clin Endocrinol Diabetes. 2007 Feb;115(2):105-7
pubmed: 17318769
Int J Cardiol. 2018 Jul 1;262:66-70
pubmed: 29605469
Inflammation. 2012 Jun;35(3):834-40
pubmed: 21935671
J Am Heart Assoc. 2020 Jul 7;9(13):e015261
pubmed: 32552251
Mol Med. 2015 Oct 27;21 Suppl 1:S32-40
pubmed: 26605646
J Cell Mol Med. 2020 Jun;24(11):6350-6361
pubmed: 32307869
Eur J Echocardiogr. 2009 Aug;10(6):723-5
pubmed: 19406839
J Am Soc Echocardiogr. 2017 Apr;30(4):372-392
pubmed: 28385280
Thromb Haemost. 2015 Nov;114(5):994-1003
pubmed: 26202300
Polymers (Basel). 2020 Nov 25;12(12):
pubmed: 33255639
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):638-655
pubmed: 31893948
Diabetologia. 2001 Feb;44(2):129-46
pubmed: 11270668
Circulation. 2006 May 2;113(17):2113-9
pubmed: 16636166
J Am Coll Cardiol. 2016 Jun 7;67(22):2565-74
pubmed: 27050187
Int J Cardiol. 2017 Oct 1;244:248-253
pubmed: 28684044
Int J Cardiol. 2009 Jun 12;135(1):4-13
pubmed: 19386374
Expert Rev Mol Med. 2009 Mar 12;11:e9
pubmed: 19278572
Vascul Pharmacol. 2020 Jul;130:106679
pubmed: 32387621
J Am Coll Cardiol. 1993 Apr;21(5):1220-5
pubmed: 8459080