Relationships among tau burden, atrophy, age, and naming in the aphasic variant of Alzheimer's disease.
Age Factors
Aged
Alzheimer Disease
/ pathology
Aphasia, Primary Progressive
/ diagnostic imaging
Atrophy
/ pathology
Brain
/ pathology
Brain Cortical Thickness
Female
Humans
Language Tests
/ statistics & numerical data
Male
Positron-Emission Tomography
Temporal Lobe
/ pathology
tau Proteins
/ metabolism
AV-1451
atrophy
cortical thickness
magnetic resonance imaging
naming
positron emission tomography
primary progressive aphasia
tau positron emission tomography
volumetric magnetic resonance imaging
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
12
07
2021
received:
02
12
2020
accepted:
14
07
2021
pubmed:
9
9
2021
medline:
5
2
2022
entrez:
8
9
2021
Statut:
ppublish
Résumé
Examination of pathologic, anatomic, and cognitive relationships has been limited in primary progressive aphasia (PPA) with underlying Alzheimer's disease (AD) neuropathology. Spatial relationships between tau positron emission tomography (PET), cortical thickness, age, and naming on the Boston Naming Test (BNT) in PPA with biomarker evidence of AD (PPA-AD) were examined. Higher tau PET burden was associated with atrophy and younger age. There was a significant left-lateralized relationship between lower BNT and more atrophy, and between lower BNT and increased tau burden. Variance in naming was primarily shared between tau and atrophy (51%), but naming was uniquely explained more by atrophy (32%) than tau (16%). Higher left anterior temporal tau burden was associated with greater 1-year rate of decline in naming. PPA-AD has a similar relationship between abnormal biomarkers as first described in amnestic AD, with differing spatial extent, reflecting the left-lateralized nature of the language network.
Identifiants
pubmed: 34494711
doi: 10.1002/alz.12445
pmc: PMC8648928
mid: NIHMS1730515
doi:
Substances chimiques
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1788-1797Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC008552
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056258
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG020506
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075075
Pays : United States
Informations de copyright
© 2021 the Alzheimer's Association.
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