The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells.
Animals
Antioxidants
/ pharmacology
Antiviral Agents
/ pharmacology
Apoptosis
/ drug effects
Basigin
/ metabolism
Cytokines
/ metabolism
Epithelial Cells
Heparan Sulfate Proteoglycans
/ metabolism
Humans
Inflammation
Interferons
/ metabolism
Oxidative Stress
/ drug effects
Peptides
/ pharmacology
SARS-CoV-2
/ drug effects
Spike Glycoprotein, Coronavirus
/ metabolism
Virus Attachment
/ drug effects
Virus Internalization
/ drug effects
Virus Replication
/ drug effects
4F
ApoA-I mimetic peptides
COVID-19
SARS-CoV-2
antioxidants
antivirals
apoptosis
inflammation
therapeutics
Journal
Virulence
ISSN: 2150-5608
Titre abrégé: Virulence
Pays: United States
ID NLM: 101531386
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
8
9
2021
pubmed:
9
9
2021
medline:
16
9
2021
Statut:
ppublish
Résumé
An oral antiviral against SARS-CoV-2 that also attenuates inflammatory instigators of severe COVID-19 is not available to date. Herein, we show that the apoA-I mimetic peptide 4 F inhibits Spike mediated viral entry and has antiviral activity against SARS-CoV-2 in human lung epithelial Calu3 and Vero-E6 cells. In SARS-CoV-2 infected Calu3 cells, 4 F upregulated inducers of the interferon pathway such as MX-1 and Heme oxygenase 1 (HO-1) and downregulated mitochondrial reactive oxygen species (mito-ROS) and CD147, a host protein that mediates viral entry. 4 F also reduced associated cellular apoptosis and secretion of IL-6 in both SARS-CoV-2 infected Vero-E6 and Calu3 cells. Thus, 4 F attenuates
Identifiants
pubmed: 34494942
doi: 10.1080/21505594.2021.1964329
pmc: PMC8437485
doi:
Substances chimiques
Antioxidants
0
Antiviral Agents
0
Cytokines
0
Heparan Sulfate Proteoglycans
0
Peptides
0
Spike Glycoprotein, Coronavirus
0
apolipoprotein A-I mimetic peptide 4F
0
spike protein, SARS-CoV-2
0
Basigin
136894-56-9
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2214-2227Subventions
Organisme : NIA NIH HHS
ID : R01 AG059502
Pays : United States
Organisme : NINR NIH HHS
ID : R21 NR010361
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI108272
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM055052
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI028697
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG059462
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071776
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG025501
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI036178
Pays : United States
Organisme : NIA NIH HHS
ID : R43 AG059501
Pays : United States
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