A roadmap for the Human Developmental Cell Atlas.
Adult
Animals
Atlases as Topic
Cell Culture Techniques
Cell Movement
Cell Survival
Cell Tracking
Cells
/ cytology
Data Visualization
Developmental Biology
/ methods
Embryo, Mammalian
/ cytology
Female
Fetus
/ cytology
Humans
Imaging, Three-Dimensional
Information Dissemination
Male
Models, Animal
Organogenesis
/ genetics
Organoids
/ cytology
Stem Cells
/ cytology
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
08
09
2020
accepted:
07
05
2021
entrez:
9
9
2021
pubmed:
10
9
2021
medline:
1
10
2021
Statut:
ppublish
Résumé
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.
Identifiants
pubmed: 34497388
doi: 10.1038/s41586-021-03620-1
pii: 10.1038/s41586-021-03620-1
pmc: PMC10337595
mid: NIHMS1907109
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
196-205Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R35 NS097305
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH114825
Pays : United States
Investigateurs
Pascal Barbry
(P)
Omer Bayraktar
(O)
Sam Behjati
(S)
Andreas Bosio
(A)
Bruno Canque
(B)
Frédéric Chalmel
(F)
Yorick Gitton
(Y)
Deborah Henderson
(D)
Anne Jorgensen
(A)
Steven Lisgo
(S)
Jinyue Liu
(J)
Emma Lundberg
(E)
Jean-Léon Maitre
(JL)
Séverine Mazaud-Guittot
(S)
Elizabeth Robertson
(E)
Antoine Rolland
(A)
Raphael Scharfmann
(R)
Michèle Souyri
(M)
Erik Sundström
(E)
Stéphane Zaffran
(S)
Matthias Zilbauer
(M)
Informations de copyright
© 2021. Springer Nature Limited.
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