A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.
schizophrenia
structure
subcortical shape
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
13
07
2021
received:
17
06
2020
accepted:
14
07
2021
pubmed:
10
9
2021
medline:
29
3
2022
entrez:
9
9
2021
Statut:
ppublish
Résumé
Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
Identifiants
pubmed: 34498337
doi: 10.1002/hbm.25625
pmc: PMC8675416
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
352-372Subventions
Organisme : NIH HHS
ID : T32 MH073526
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NIH HHS
ID : MH098130
Pays : United States
Organisme : CSRD VA
ID : I01 CX000497
Pays : United States
Organisme : NIH HHS
ID : R01EB015611
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIH HHS
ID : R21 MH097196
Pays : United States
Organisme : Wellcome Trust
ID : 072894/2/03/Z
Pays : United Kingdom
Organisme : NIH HHS
ID : R37MH43375
Pays : United States
Organisme : NIH HHS
ID : P50 MH071616
Pays : United States
Organisme : NIH HHS
ID : T32 AG058507
Pays : United States
Organisme : NIH HHS
ID : 1RC1MH089257
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB015611
Pays : United States
Organisme : NIH HHS
ID : MH064045
Pays : United States
Organisme : NIH HHS
ID : R01 HD050735
Pays : United States
Organisme : NIH HHS
ID : U54EB020403
Pays : United States
Organisme : NIH HHS
ID : P41RR14075
Pays : United States
Organisme : NIH HHS
ID : UL1 TR000153
Pays : United States
Organisme : NIH HHS
ID : R01 DA053028
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIH HHS
ID : U24 RR021992
Pays : United States
Organisme : NIH HHS
ID : U24RR021992
Pays : United States
Organisme : NIH HHS
ID : U01 MH097435
Pays : United States
Organisme : NIH HHS
ID : U24 RR021382A
Pays : United States
Organisme : NIH HHS
ID : MO1 RR025758
Pays : United States
Organisme : Science Foundation Ireland
ID : 12/IP/1359
Pays : Ireland
Organisme : NIBIB NIH HHS
ID : R01 EB020062
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH123163
Pays : United States
Organisme : NIH HHS
ID : MH 60722
Pays : United States
Organisme : Science Foundation Ireland
ID : 08/IN.1/B1916
Pays : Ireland
Organisme : NCATS NIH HHS
ID : UL1 TR000153
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Organisme : NIH HHS
ID : MH085096
Pays : United States
Organisme : Medical Research Council
ID : G0500092
Pays : United Kingdom
Organisme : NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIH HHS
ID : R21MH097196
Pays : United States
Organisme : NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIH HHS
ID : S10 OD023696
Pays : United States
Organisme : NIH HHS
ID : R01EB005846
Pays : United States
Organisme : NIH HHS
ID : TR000153
Pays : United States
Organisme : NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIH HHS
ID : R01 MH056584
Pays : United States
Organisme : NIH HHS
ID : MH019112
Pays : United States
Organisme : NIH HHS
ID : U24 RR025736
Pays : United States
Organisme : NIH HHS
ID : R01MH074797
Pays : United States
Organisme : NIH HHS
ID : R01 MH084803
Pays : United States
Organisme : NIH HHS
ID : R01 EB020062
Pays : United States
Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Brain Imaging Behav. 2014 Jun;8(2):153-82
pubmed: 24399358
Genes Brain Behav. 2014 Nov;13(8):821-30
pubmed: 25199620
Neuroimage Clin. 2017 Nov 08;17:563-569
pubmed: 29201642
Can J Psychiatry. 2007 Mar;52(3):158-66
pubmed: 17479523
Brain. 2007 Mar;130(Pt 3):678-92
pubmed: 17303593
Neuroimage. 2004 Jun;22(2):831-40
pubmed: 15193612
Schizophr Res. 2004 Dec 15;72(1):41-51
pubmed: 15531406
Schizophr Res. 2015 Dec;169(1-3):453-457
pubmed: 26475214
Neuroimage. 2010 Oct 1;52(4):1181-9
pubmed: 20573561
Neuroimage. 2008 Oct 1;42(4):1430-8
pubmed: 18675553
Psychiatry Res. 2014 Aug 30;223(2):75-83
pubmed: 24957866
J Neurosci. 2007 Dec 12;27(50):13835-42
pubmed: 18077695
Neuroimage. 2008 Jan 1;39(1):32-9
pubmed: 17942324
Am J Psychiatry. 1992 Jul;149(7):890-7
pubmed: 1609867
Biol Psychiatry. 2008 Dec 15;64(12):1060-8
pubmed: 18814865
Psychol Med. 2014 Sep;44(12):2489-501
pubmed: 24443827
Clin Neurosci. 1995;3(2):89-97
pubmed: 7583624
Hum Brain Mapp. 2022 Jan;43(1):341-351
pubmed: 32198905
Indian J Psychol Med. 2013 Jan;35(1):34-8
pubmed: 23833340
Hum Brain Mapp. 2015 Apr;36(4):1458-69
pubmed: 25504933
Front Hum Neurosci. 2016 Jul 29;10:373
pubmed: 27524962
Brain. 1999 Apr;122 ( Pt 4):593-624
pubmed: 10219775
Psychol Med. 2015 May;45(7):1343-61
pubmed: 25650668
Am J Psychiatry. 1995 May;152(5):738-48
pubmed: 7726314
Neuroimage. 2004;23 Suppl 1:S56-68
pubmed: 15501101
Hippocampus. 1995;5(6):511-33
pubmed: 8646279
Tidsskr Nor Laegeforen. 2013 Apr 23;133(8):850-3
pubmed: 23612107
Trends Neurosci. 2019 Mar;42(3):205-220
pubmed: 30621912
Biol Psychiatry. 1999 Sep 1;46(5):627-49
pubmed: 10472416
Biol Psychiatry. 2015 Jan 15;77(2):137-46
pubmed: 24976379
Neuroimage Clin. 2017 Feb 13;14:441-449
pubmed: 28275544
Neuroimage. 2018 Feb 15;167:104-120
pubmed: 29155184
Synapse. 2013 May;67(5):224-34
pubmed: 23335099
Arch Gen Psychiatry. 1997 Oct;54(10):943-52
pubmed: 9337775
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3863-8
pubmed: 16537458
Schizophr Res. 2009 Mar;108(1-3):104-13
pubmed: 19157788
Psychol Med. 2014 Jun;44(8):1591-604
pubmed: 24067252
Schizophr Res. 2017 Feb;180:28-35
pubmed: 27567291
Biol Psychiatry. 2008 Jul 15;64(2):111-20
pubmed: 18295189
J Clin Psychiatry. 2003 Jun;64(6):663-7
pubmed: 12823080
Front Syst Neurosci. 2012 Mar 30;6:20
pubmed: 22479239
Biol Psychiatry. 2019 Oct 1;86(7):545-556
pubmed: 31443932
Dialogues Clin Neurosci. 2007;9(2):141-51
pubmed: 17726913
Arch Gen Psychiatry. 1989 Dec;46(12):1145-50
pubmed: 2589928
Schizophr Res. 2011 Dec;133(1-3):68-76
pubmed: 21981933
Curr Behav Neurosci Rep. 2016 Jun;3(2):165-175
pubmed: 27766192
BMC Med Res Methodol. 2002 Aug 09;2:10
pubmed: 12171604
Int Rev Psychiatry. 2007 Aug;19(4):397-406
pubmed: 17671872
Curr Neuropharmacol. 2015;13(4):422-34
pubmed: 26412062
Neuroimage Clin. 2016 Feb 23;11:276-286
pubmed: 26977397
Mol Psychiatry. 2016 Apr;21(4):585
pubmed: 26283641
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Aug;5(8):808-818
pubmed: 32600898
Neuroimage. 2020 Sep;218:116956
pubmed: 32470572
Am J Psychiatry. 2001 Nov;158(11):1809-17
pubmed: 11691686
JAMA Psychiatry. 2017 Oct 1;74(10):1065-1075
pubmed: 28746715
Biol Psychiatry. 2002 May 15;51(10):827-37
pubmed: 12007457
Hum Brain Mapp. 2022 Jan;43(1):352-372
pubmed: 34498337
Schizophr Res. 2017 Feb;180:21-27
pubmed: 27613507
Schizophr Res. 1999 Nov 30;40(2):87-99
pubmed: 10593448
Schizophr Bull. 2013 Sep;39(5):1129-38
pubmed: 23042112
Psychiatry Res. 2013 Jan 30;211(1):1-10
pubmed: 23142194
Hum Psychopharmacol. 2016 Jan;31(1):64-9
pubmed: 26270489
Psychopharmacology (Berl). 2010 Jan;208(1):131-41
pubmed: 19936716
Neuroimage. 2008 Jul 1;41(3):735-46
pubmed: 18455931
Neuroimage Clin. 2018 Jul 10;20:169-176
pubmed: 30094166
Schizophr Res. 1997 Dec 19;28(2-3):143-56
pubmed: 9468349
Hum Brain Mapp. 2012 Sep;33(9):2081-91
pubmed: 22241649
Schizophr Res. 2015 Dec;169(1-3):76-82
pubmed: 26386898
J Comp Neurol. 1997 May 12;381(3):335-52
pubmed: 9133572
Biol Psychiatry. 1999 May 1;45(9):1099-119
pubmed: 10331102
Neuroimage. 2011 Jun 15;56(4):1993-2010
pubmed: 21440071
Nat Genet. 2019 Nov;51(11):1624-1636
pubmed: 31636452
Lancet. 1998 Nov 21;352(9141):1669-73
pubmed: 9853440
J Neurol Neurosurg Psychiatry. 1998 Oct;65(4):446-53
pubmed: 9771764
PLoS One. 2019 May 9;14(5):e0216554
pubmed: 31071157
Neuropsychopharmacology. 2005 Sep;30(9):1649-61
pubmed: 15756305
Stat Med. 1990 Jul;9(7):811-8
pubmed: 2218183
Am J Psychiatry. 2020 Jul 1;177(7):589-600
pubmed: 32046535
Psychol Med. 2013 Jul;43(7):1353-63
pubmed: 23186886
Biol Psychiatry. 2001 Nov 15;50(10):729-42
pubmed: 11720691
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Eur Arch Psychiatry Clin Neurosci. 2011 Nov;261 Suppl 2:S150-4
pubmed: 21866371
Biol Psychiatry. 2000 Jun 1;47(11):944-53
pubmed: 10838062
Nat Neurosci. 2001 Dec;4(12):1253-8
pubmed: 11694885
Curr Top Behav Neurosci. 2010;4:243-81
pubmed: 21312403
Am J Psychiatry. 2004 May;161(5):896-902
pubmed: 15121656
Schizophr Res. 2001 Apr 15;49(1-2):1-52
pubmed: 11343862
Neuroimage. 2007 Feb 1;34(3):1149-59
pubmed: 17185000
Proc IEEE Int Symp Biomed Imaging. 2015 Apr;2015:1402-1406
pubmed: 26413211
Hum Brain Mapp. 2013 Oct;34(10):2635-54
pubmed: 22611030
Schizophr Bull. 2016 May;42(3):588-99
pubmed: 26547223
Arch Gen Psychiatry. 1993 Mar;50(3):169-77
pubmed: 7679891
Neuroimage. 2020 Mar;208:116450
pubmed: 31821869
J Neurosci. 2003 Feb 1;23(3):994-1005
pubmed: 12574429
Arch Gen Psychiatry. 2011 Feb;68(2):128-37
pubmed: 21300943
Hippocampus. 2009 Jun;19(6):541-8
pubmed: 19405129
Arch Gen Psychiatry. 2000 Apr;57(4):349-56
pubmed: 10768696
Eur Arch Psychiatry Clin Neurosci. 2013 Sep;263(6):469-73
pubmed: 23161338
Front Psychiatry. 2012 Nov 12;3:96
pubmed: 23162479
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Nat Commun. 2016 Dec 15;7:13738
pubmed: 27976715
Schizophr Res. 2007 Jan;89(1-3):59-71
pubmed: 17071057
Addict Biol. 2020 Nov;25(6):e12830
pubmed: 31746534
J Comp Neurol. 1995 Dec 25;363(4):615-641
pubmed: 8847421
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11406-11
pubmed: 9736749
Arch Gen Psychiatry. 2010 Feb;67(2):133-43
pubmed: 20124113
Schizophr Bull. 2011 Sep;37 Suppl 2:S33-40
pubmed: 21860045
Hum Brain Mapp. 2009 Apr;30(4):1236-45
pubmed: 18570200
Neuropsychol Rev. 2009 Sep;19(3):385-98
pubmed: 19728098
EBioMedicine. 2018 Oct;36:429-435
pubmed: 30241918
Dialogues Clin Neurosci. 2010;12(3):317-32
pubmed: 20954428
Mol Cell Neurosci. 2006 Aug;32(4):356-65
pubmed: 16844384
Am J Psychiatry. 2005 Dec;162(12):2233-45
pubmed: 16330585
Front Syst Neurosci. 2013 Aug 30;7:45
pubmed: 24009563
Schizophr Res. 2016 Jun;173(3):182-191
pubmed: 25623601
Mol Psychiatry. 2016 Oct;21(10):1460-6
pubmed: 26782053
Neuroimage Clin. 2019;22:101781
pubmed: 30991613
Am J Psychiatry. 2002 Dec;159(12):2000-6
pubmed: 12450948
Neuroimage. 2007 Oct 15;38(1):43-56
pubmed: 17825583
Psychiatry Res. 1997 Feb 7;68(2-3):99-109
pubmed: 9104757
Br J Psychiatry. 1998 Feb;172:110-20
pubmed: 9519062
Dev Cogn Neurosci. 2020 Aug;44:100782
pubmed: 32716847
Front Behav Neurosci. 2010 Feb 12;4:4
pubmed: 20179788
Arch Gen Psychiatry. 1993 Mar;50(3):178-87
pubmed: 7679892
J Neurosci Res. 2017 Jan 2;95(1-2):371-379
pubmed: 27870421
Neuroimage. 2001 Sep;14(3):531-45
pubmed: 11506528
Am J Psychiatry. 2016 Mar 1;173(3):232-43
pubmed: 26621570
J Psychiatr Res. 2012 Oct;46(10):1249-56
pubmed: 22790253
J Neurophysiol. 2011 Sep;106(3):1068-77
pubmed: 21676936
Schizophr Res. 2011 Apr;127(1-3):46-57
pubmed: 21300524
Transl Psychiatry. 2020 Mar 20;10(1):100
pubmed: 32198361
Biol Psychiatry. 2001 Jul 15;50(2):84-97
pubmed: 11526999
Schizophr Bull. 2019 Mar 7;45(2):484-494
pubmed: 29939349
Am J Med Genet B Neuropsychiatr Genet. 2019 Mar;180(2):138-149
pubmed: 30468562
Schizophr Res. 1988 Jan-Feb;1(1):47-53
pubmed: 3154506
Med Image Comput Comput Assist Interv. 2008;11(Pt 2):914-21
pubmed: 18982692
Psychol Bull. 1992 Jul;112(1):155-9
pubmed: 19565683
Cereb Cortex. 2020 Apr 14;30(4):2281-2294
pubmed: 31819950