Spatial coefficient of variation of arterial spin labeling MRI for detecting hemodynamic disturbances measured with
Arterial spin labeling
Cerebral hemodynamics
Moyamoya disease
Oxygen extraction fraction
Perfusion imaging
Spatial coefficient of variation
Journal
Neuroradiology
ISSN: 1432-1920
Titre abrégé: Neuroradiology
Pays: Germany
ID NLM: 1302751
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
02
06
2021
accepted:
30
08
2021
pubmed:
10
9
2021
medline:
12
3
2022
entrez:
9
9
2021
Statut:
ppublish
Résumé
The aim of this study was to investigate whether the spatial coefficient of variation of arterial spin labeling (ASL-CoV) acquired in clinical settings can be used to estimate the hemodynamic disturbances measured with We evaluated 68 adult patients with moyamoya disease who underwent ASL (postlabeling delay (PLD) = 1525 ms and 2525 ms) and PET. Regional values were measured using the middle cerebral artery territorial atlas divided into proximal, middle, and distal regions based on the arterial transit time, and correlations of ASL-CoV with cerebral blood flow, cerebral blood volume, mean transit time, and OEF, as well as the relationship between increased OEF and ASL-CoV, were evaluated. Regardless of the choice of region and PLD, ASL-CoV was significantly correlated with PET-measured parameters, including OEF (|ρ|= 0.30-0.80, P < 0.001). Regions with an increased OEF showed a significantly higher ASL-CoV than regions with a nonincreased OEF (P ≤ 0.03) regardless of the choice of region and PLD. The accuracy of identification of an increased OEF was highest when using a PLD of 1525 ms and the middle region (area under the curve = 0.750; using a cutoff value of 31.27, sensitivity = 97.4%, specificity = 41.7%, negative predictive value = 92.6%, and positive predictive value = 67.9%). ASL-CoV may help identify patients with increased OEF.
Identifiants
pubmed: 34499192
doi: 10.1007/s00234-021-02802-y
pii: 10.1007/s00234-021-02802-y
doi:
Substances chimiques
Spin Labels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
675-684Subventions
Organisme : Japan Society for the Promotion of Science
ID : 24592115
Organisme : The Japanese Society of Neuroradiology
ID : a research grant (2015-2017)
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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