Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer's Disease.
Alzheimer’s disease
acetylcholinesterase
butyrylcholinesterase
docking study
isoquinoline alkaloids
monoaminooxidase
neuroprotective activity
prolyl oligopeptidase
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Aug 2021
29 Aug 2021
Historique:
received:
12
07
2021
revised:
22
08
2021
accepted:
27
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is only symptomatic and available drugs are not able to modify AD progression. Considering the increase in life expectancy worldwide, AD rates are predicted to increase enormously, and thus the search for new AD drugs is urgently needed. Due to their complex nitrogen-containing structures, alkaloids are considered to be promising candidates for use in the treatment of AD. Since the introduction of galanthamine as an antidementia drug in 2001, Amaryllidaceae alkaloids (AAs) and further isoquinoline alkaloids (IAs) have been one of the most studied groups of alkaloids. In the last few years, several compounds of new structure types have been isolated and evaluated for their biological activity connected with AD. The present review aims to comprehensively summarize recent progress on AAs and IAs since 2010 up to June 2021 as potential drugs for the treatment of AD.
Identifiants
pubmed: 34500673
pii: molecules26175240
doi: 10.3390/molecules26175240
pmc: PMC8434202
pii:
doi:
Substances chimiques
Amaryllidaceae Alkaloids
0
Prolyl Oligopeptidases
EC 3.4.21.26
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grantová Agentura, Univerzita Karlova
ID : GA UK 328121; SVV UK 260 548
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : reg. No. CZ.02.1.01/0.0/0.0/18_069/0010046
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