Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice.

Adaptor Proteins, Signal Transducing / genetics Animals Antibodies, Monoclonal Bone Marrow / pathology Cytokines Female Gene Knockout Techniques Hematopoietic Stem Cells Inflammation / chemically induced Male Mice Mice, Knockout Myelopoiesis
aging genetic animal models osteoimmunology osteopetrosis

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 Aug 2021
Historique:
received: 02 08 2021
revised: 18 08 2021
accepted: 20 08 2021
entrez: 10 9 2021
pubmed: 11 9 2021
medline: 28 10 2021
Statut: epublish

Résumé

Romosozumab, a humanized monoclonal antibody specific for sclerostin (SOST), has been approved for treatment of postmenopausal women with osteoporosis at a high risk for fracture. Previous work in sclerostin global knockout (

Identifiants

DOI: 10.3390/ijms22179111 PMID: 34502021 PMC: PMC8431516
pubmed: 34502021
pii: ijms22179111
doi: 10.3390/ijms22179111
pmc: PMC8431516
pii:
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Antibodies, Monoclonal 0
Cytokines 0
Sost protein, mouse 0
romosozumab 3VHF2ZD92J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R15 HL121786
Pays : United States
Organisme : NHLBI NIH HHS
ID : R15HL121786
Pays : United States
Organisme : Cancer Research Coordinating Committee
ID : CRR-13-201415

Références

Nat Cell Biol. 2016 Jun;18(6):607-18
pubmed: 27111842
J Exp Med. 2000 Nov 6;192(9):1273-80
pubmed: 11067876
Front Immunol. 2016 Nov 14;7:502
pubmed: 27895645
Acta Haematol Pol. 1994;25(3):253-60
pubmed: 7992598
Sci Rep. 2018 May 29;8(1):8308
pubmed: 29844356
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
J Biol Chem. 2011 Jun 3;286(22):19489-500
pubmed: 21471202
Bone. 2018 Feb;107:93-103
pubmed: 29129759
Blood. 2019 Jan 3;133(1):40-50
pubmed: 30401705
Blood. 2015 Apr 23;125(17):2621-9
pubmed: 25762174
J Biol Chem. 2003 May 23;278(21):19534-40
pubmed: 12642582
Dev Cell. 2018 Mar 12;44(5):634-641.e4
pubmed: 29456137
J Immunol. 2014 Jan 1;192(1):27-33
pubmed: 24363432
J Bone Miner Res. 2008 Jun;23(6):860-9
pubmed: 18269310
Nat Med. 1996 Sep;2(9):1011-6
pubmed: 8782459
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1195-200
pubmed: 9448308
Haematologica. 2020 Jan;105(1):38-46
pubmed: 31806690
Nature. 2019 May;569(7755):222-228
pubmed: 30971824
J Cell Physiol. 2014 May;229(5):640-50
pubmed: 24446199
Nat Immunol. 2006 Oct;7(10):1037-47
pubmed: 16951686
Int J Hematol. 2017 Jul;106(1):45-54
pubmed: 28534115
Sci Transl Med. 2016 Mar 16;8(330):330ra35
pubmed: 27089204
Adv Hematol. 2010;2010:508739
pubmed: 20368776
Lancet. 1974 Apr 20;1(7860):701-3
pubmed: 4132422
J Lab Clin Med. 1983 Feb;101(2):295-307
pubmed: 6822764
J Autoimmun. 2016 Dec;75:58-67
pubmed: 27453063
Exp Hematol. 2016 Jun;44(6):451-7
pubmed: 27016274
Hum Mol Genet. 2001 Mar 1;10(5):537-43
pubmed: 11181578
Nature. 2014 Apr 10;508(7495):269-73
pubmed: 24590072
J Blood Med. 2010;1:13-9
pubmed: 22282679
J Biol Chem. 2005 May 20;280(20):19883-7
pubmed: 15778503
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Am J Clin Pathol. 1983 Sep;80(3):322-6
pubmed: 6881096
Immunol Rev. 2018 Jan;281(1):8-27
pubmed: 29247995
Arthritis Res Ther. 2013;15(5):R125
pubmed: 24432364
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3234-8
pubmed: 7536928
J Immunol. 2010 Apr 15;184(8):4470-8
pubmed: 20220089
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
Front Med. 2019 Jun;13(3):314-329
pubmed: 30066061
Dev Comp Immunol. 2016 May;58:30-9
pubmed: 26577994
Curr Osteoporos Rep. 2020 Feb;18(1):32-37
pubmed: 31970653
J Clin Invest. 1987 Feb;79(2):319-26
pubmed: 3543052
Antioxid Redox Signal. 2018 Jul 10;29(2):191-204
pubmed: 29113449
Drugs. 2019 Mar;79(4):471-476
pubmed: 30805895
Cell. 2005 Jul 1;121(7):967-70
pubmed: 15989946
Cell Stem Cell. 2015 Jul 2;17(1):35-46
pubmed: 26095048
Blood Cells. 1978;4(1-2):7-25
pubmed: 747780
J Emerg Med. 1991;9 Suppl 1:71-4
pubmed: 1955687
Nature. 2003 May 22;423(6938):409-14
pubmed: 12717450
Radiat Res. 1961 Feb;14:213-22
pubmed: 13776896
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Nat Med. 2016 Aug;22(8):945-51
pubmed: 27428900
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14541-6
pubmed: 11724967
J Cell Physiol. 2018 Feb;233(2):1156-1167
pubmed: 28460416
Nature. 1998 Jun 11;393(6685):595-9
pubmed: 9634238
Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9194-9
pubmed: 15967997
Sci Transl Med. 2013 Nov 13;5(211):211ra158
pubmed: 24225945
Trends Immunol. 2015 Dec;36(12):815-824
pubmed: 26611154
Dev Biol. 2010 Jun 15;342(2):169-79
pubmed: 20359476
Rare Dis. 2015 Aug 11;3(1):e1073430
pubmed: 26459672
Blood. 1995 Feb 15;85(4):989-96
pubmed: 7849320
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E478-86
pubmed: 25605937
Nature. 1996 Aug 15;382(6592):635-8
pubmed: 8757135
Oncol Lett. 2015 Oct;10(4):2390-2394
pubmed: 26622857
Exp Hematol. 2013 Jan;41(1):3-16
pubmed: 23022129
Health Sci Rep. 2018 May 02;1(5):e50
pubmed: 30623074
Blood. 1999 May 15;93(10):3294-301
pubmed: 10233881
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Int J Hematol. 2018 Feb;107(2):166-172
pubmed: 29022201
Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17031-6
pubmed: 19805069
J Bone Miner Res. 2018 Oct;33(10):1748-1759
pubmed: 29750826
J Bone Miner Res. 2010 Jul;25(7):1468-86
pubmed: 20533309
Blood. 2008 Jan 15;111(2):492-503
pubmed: 17914027
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Nature. 2016 Apr 21;532(7599):323-8
pubmed: 27074509
Clin Rheumatol. 2020 Nov;39(11):3261-3276
pubmed: 32385757
Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6
pubmed: 29276143
Genome Biol. 2013 Apr 25;14(4):R36
pubmed: 23618408
Int J Hematol. 2014 Nov;100(5):429-36
pubmed: 25227185
Science. 2007 Nov 23;318(5854):1296-9
pubmed: 18033883
Sci Rep. 2018 Feb 22;8(1):3492
pubmed: 29472591
J Bone Miner Res. 2012 Jul;27(7):1451-61
pubmed: 22434688
J Immunol. 2011 Nov 1;187(9):4835-43
pubmed: 21930960
J Med Genet. 2002 Feb;39(2):91-7
pubmed: 11836356
PLoS One. 2011;6(12):e28669
pubmed: 22194881
Nat Immunol. 2006 Oct;7(10):1048-56
pubmed: 16951689
Curr Osteoporos Rep. 2019 Apr;17(2):49-58
pubmed: 30835038
J Med Imaging Radiat Oncol. 2012 Oct;56(5):538-44
pubmed: 23043573
Bone. 2017 Mar;96:63-75
pubmed: 27789417
Endocrinology. 1995 Jun;136(6):2752-9
pubmed: 7750500
JBMR Plus. 2017 Dec 29;2(1):47-54
pubmed: 30283889
Adipocyte. 2017 Jul 3;6(3):193-204
pubmed: 28872979
J Nutr Metab. 2013;2013:486186
pubmed: 23509616
J Bone Miner Res. 2017 Apr;32(4):802-813
pubmed: 27796050
Bone. 1995 Aug;17(2 Suppl):71S-75S
pubmed: 8579902
Curr Osteoporos Rep. 2018 Apr;16(2):95-104
pubmed: 29492879
Cell Rep. 2018 Dec 11;25(11):2992-3005.e5
pubmed: 30540934
An Acad Bras Cienc. 2017 Jan-Mar;89(1):285-299
pubmed: 28423084
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W305-11
pubmed: 19465376
Blood. 2012 Oct 25;120(17):3425-35
pubmed: 22859604
Immunity. 2006 Dec;25(6):977-88
pubmed: 17174120
Int J Mol Sci. 2018 Aug 10;19(8):
pubmed: 30103411

Auteurs

Cristine Donham (C)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Quantitative and Systems Biology Graduate Program, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Betsabel Chicana (B)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Quantitative and Systems Biology Graduate Program, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Alexander G Robling (AG)

Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Roudebush VA Medical Center, Indianapolis, IN 46202, USA.

Asmaa Mohamed (A)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Sonny Elizaldi (S)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Michael Chi (M)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Brian Freeman (B)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Alberto Millan (A)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Quantitative and Systems Biology Graduate Program, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Deepa K Murugesh (DK)

Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

Nicholas R Hum (NR)

Quantitative and Systems Biology Graduate Program, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
ORCID: 0000-0003-1605-3193

Aimy Sebastian (A)

Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
ORCID: 0000-0002-7822-7040

Gabriela G Loots (GG)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Quantitative and Systems Biology Graduate Program, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
ORCID: 0000-0001-9546-5561

Jennifer O Manilay (JO)

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Quantitative and Systems Biology Graduate Program, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Eucaryotes › Animaux › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Sclerostin Depletion Induces Inflammation in...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Leucopoïèse › Myélopoïèse › Sclerostin Depletion Induces Inflammation in...