IGF-1 and IGFBP-3 in Inflammatory Cachexia.
GH
IGF-1
IGFBP-3
cachexia
cytokines
glucocorticoids
inflammation
muscle wasting
nitric oxide
sepsis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Aug 2021
31 Aug 2021
Historique:
received:
10
07
2021
revised:
05
08
2021
accepted:
28
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Inflammation induces a wide response of the neuroendocrine system, which leads to modifications in all the endocrine axes. The hypothalamic-growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis is deeply affected by inflammation, its response being characterized by GH resistance and a decrease in circulating levels of IGF-1. The endocrine and metabolic responses to inflammation allow the organism to survive. However, in chronic inflammatory conditions, the inhibition of the hypothalamic-GH-IGF-1 axis contributes to the catabolic process, with skeletal muscle atrophy and cachexia. Here, we review the changes in pituitary GH secretion, IGF-1, and IGF-1 binding protein-3 (IGFBP-3), as well as the mechanism that mediated those responses. The contribution of GH and IGF-1 to muscle wasting during inflammation has also been analyzed.
Identifiants
pubmed: 34502376
pii: ijms22179469
doi: 10.3390/ijms22179469
pmc: PMC8430490
pii:
doi:
Substances chimiques
IGF1 protein, human
0
IGFBP3 protein, human
0
Insulin
0
Insulin-Like Growth Factor Binding Protein 3
0
Human Growth Hormone
12629-01-5
Insulin-Like Growth Factor I
67763-96-6
Growth Hormone
9002-72-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Comunidad de Madrid, spain
ID : IND2017/BIO7701
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