The Multifaceted Role of Serotonin in Intestinal Homeostasis.
inflammatory bowel disease
intestine
microbiome
tryptophan
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Aug 2021
31 Aug 2021
Historique:
received:
03
08
2021
revised:
26
08
2021
accepted:
27
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
26
10
2021
Statut:
epublish
Résumé
The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.
Identifiants
pubmed: 34502396
pii: ijms22179487
doi: 10.3390/ijms22179487
pmc: PMC8431144
pii:
doi:
Substances chimiques
Serotonin
333DO1RDJY
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cell Mol Gastroenterol Hepatol. 2019;7(4):709-728
pubmed: 30716420
Am J Physiol Gastrointest Liver Physiol. 2002 May;282(5):G877-93
pubmed: 11960784
J Immunol. 2006 Nov 1;177(9):6422-32
pubmed: 17056574
J Neurogastroenterol Motil. 2017 Apr 30;23(2):151-163
pubmed: 28274109
J Clin Med. 2021 Jul 31;10(15):
pubmed: 34362210
Inflamm Bowel Dis. 2014 Oct;20(10):1702-7
pubmed: 25153503
Blood. 2013 Feb 7;121(6):1008-15
pubmed: 23243271
Cell Host Microbe. 2018 Jun 13;23(6):716-724
pubmed: 29902437
Cytokine. 2013 Mar;61(3):778-84
pubmed: 23410504
Gastroenterology. 2012 Apr;142(4):844-854.e4
pubmed: 22226658
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703
pubmed: 19234110
Gastroenterology. 2018 Mar;154(4):1140-1171.e1
pubmed: 29274869
Pharmaceuticals (Basel). 2018 Jun 25;11(3):
pubmed: 29941795
Int J Med Sci. 2019 Sep 7;16(9):1260-1270
pubmed: 31588192
Int J Immunopharmacol. 1994 Jul;16(7):561-7
pubmed: 7928004
Neurogastroenterol Motil. 2009 Dec;21(12):1239-49
pubmed: 19650771
Am J Pathol. 2011 Feb;178(2):662-71
pubmed: 21281798
PLoS One. 2017 Jul 6;12(7):e0180745
pubmed: 28683093
Free Radic Biol Med. 2014 Apr;69:377-89
pubmed: 24524998
Int Immunol. 2005 May;17(5):599-606
pubmed: 15802305
Int Immunopharmacol. 2011 Jan;11(1):67-73
pubmed: 20971187
PLoS One. 2013;8(1):e54840
pubmed: 23372779
PLoS Comput Biol. 2018 Jan 16;14(1):e1005939
pubmed: 29338008
J Clin Pathol. 1981 Mar;34(3):292-302
pubmed: 6453137
Brain Behav Immun. 2015 Aug;48:165-73
pubmed: 25866195
Sci Rep. 2019 Feb 14;9(1):2138
pubmed: 30765765
J Neurosci. 2011 Jun 15;31(24):8998-9009
pubmed: 21677183
Gastroenterology. 2009 Nov;137(5):1562-6
pubmed: 19789088
Neurosci Lett. 2002 Jul 5;326(3):163-6
pubmed: 12095647
FEMS Microbiol Lett. 1995 Sep 1;131(2):219-25
pubmed: 7557333
J Pharmacol Exp Ther. 2003 Jul;306(1):355-62
pubmed: 12682218
Gut. 1998 Jan;42(1):42-6
pubmed: 9505884
J Immunol. 2004 May 15;172(10):6011-9
pubmed: 15128784
Am J Clin Nutr. 1979 Jan;32(1):173-8
pubmed: 367144
Neurogastroenterol Motil. 2010 Jul;22(7):826-34, e229
pubmed: 20219086
J Parasitol. 1986 Aug;72(4):545-9
pubmed: 3783348
Gastroenterology. 2016 Nov;151(5):933-944.e3
pubmed: 27480173
J Neurosci. 2009 Aug 5;29(31):9683-99
pubmed: 19657021
Cell Mol Biol (Noisy-le-grand). 2018 Oct 30;64(13):89-96
pubmed: 30403602
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8772-7
pubmed: 20421464
Nat Immunol. 2004 Jan;5(1):104-12
pubmed: 14691478
Nat Med. 2015 Feb;21(2):166-72
pubmed: 25485911
Nat Rev Immunol. 2009 Dec;9(12):883-9
pubmed: 19935807
J Immunol. 2013 May 1;190(9):4795-804
pubmed: 23554310
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6458-6463
pubmed: 29866843
PLoS One. 2009 Jul 31;4(7):e6453
pubmed: 19649285
J Neuroimmunol. 2019 Jul 15;332:99-111
pubmed: 30999218
J Gastroenterol Hepatol. 2016 Aug;31(8):1443-52
pubmed: 26676714
Trends Neurosci. 2016 Sep;39(9):614-624
pubmed: 27450201
Int J Tryptophan Res. 2009 Mar 23;2:45-60
pubmed: 20651948
Eur J Clin Invest. 2009 May;39(5):375-83
pubmed: 19302562
Cell. 2003 Dec 26;115(7):851-62
pubmed: 14697203
Psychopharmacology (Berl). 2019 May;236(5):1671-1685
pubmed: 30155748
J Physiol. 2013 Dec 1;591(23):5939-57
pubmed: 24127620
Neurotoxicology. 2004 Jan;25(1-2):139-48
pubmed: 14697888
Gastroenterology. 2013 Jun;144(7):1466-77, 1477.e1-9
pubmed: 23395646
Gastroenterology. 2012 Aug;143(2):408-17.e2
pubmed: 22609381
J Cell Sci. 2015 Aug 1;128(15):2866-80
pubmed: 26092936
J Neuroimmunol. 2006 Dec;181(1-2):68-81
pubmed: 17011639
Aliment Pharmacol Ther. 2017 Sep;46(6):569-580
pubmed: 28737264
J Immunol. 1993 Aug 1;151(3):1175-83
pubmed: 8393041
Am J Physiol Regul Integr Comp Physiol. 2003 May;284(5):R1269-76
pubmed: 12676748
Pharmacogenet Genomics. 2009 Nov;19(11):907-9
pubmed: 19741567
Mol Interv. 2010 Aug;10(4):231-41
pubmed: 20729489
Nat Rev Microbiol. 2019 Aug;17(8):497-511
pubmed: 31249397
J Psychiatr Res. 2008 Dec;43(2):164-74
pubmed: 18456279
J Cell Physiol. 2017 Sep;232(9):2359-2372
pubmed: 27512962
Adv Exp Med Biol. 2017;1033:35-46
pubmed: 29101650
Brain Behav Immun. 1998 Dec;12(4):249-71
pubmed: 10080856
Gut. 2014 Jun;63(6):928-37
pubmed: 23749550
Mucosal Immunol. 2018 Jul;11(4):1024-1038
pubmed: 29626198
Cell Immunol. 1990 Apr 15;127(1):199-214
pubmed: 2138518
Endocr Rev. 2019 Aug 1;40(4):1092-1107
pubmed: 30901029
Gut Pathog. 2020 Jan 4;12:1
pubmed: 31911822
Biochimie. 2019 Jun;161:56-64
pubmed: 29909048
Eur J Pharmacol. 2015 Jan 5;746:293-300
pubmed: 25460023
Cell Microbiol. 2006 Apr;8(4):646-60
pubmed: 16548890
Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G803-11
pubmed: 16728728
ACS Chem Neurosci. 2017 May 17;8(5):920-931
pubmed: 28288510
Dig Dis Sci. 2002 Jan;47(1):216-24
pubmed: 11837726
PLoS One. 2008;3(10):e3301
pubmed: 18923670
Cell Host Microbe. 2014 Oct 8;16(4):495-503
pubmed: 25263219
Handb Exp Pharmacol. 2017;239:319-342
pubmed: 28035530
Clin Gastroenterol Hepatol. 2007 Jun;5(6):714-20
pubmed: 17481962
Br J Pharmacol. 2003 May;139(2):457-63
pubmed: 12770951
Prikl Biokhim Mikrobiol. 2009 Sep-Oct;45(5):550-4
pubmed: 19845286
Blood. 2006 Feb 1;107(3):1010-7
pubmed: 16223770
Am J Pathol. 2006 Sep;169(3):861-76
pubmed: 16936262
Inflamm Bowel Dis. 2017 Apr;23(4):534-550
pubmed: 28267046
J Can Assoc Gastroenterol. 2019 Aug;2(3):132-140
pubmed: 31294376
Neurogastroenterol Motil. 2005 Aug;17(4):565-74
pubmed: 16078946
Gastroenterology. 2013 Jan;144(1):145-54
pubmed: 23041323
Am J Physiol Gastrointest Liver Physiol. 2020 Dec 1;319(6):G761-G768
pubmed: 32967429
Neuroscience. 1985 Sep;16(1):223-40
pubmed: 2940472
Acta Physiol Scand. 2004 Sep;182(1):53-62
pubmed: 15329057
FASEB J. 2005 Jul;19(9):1187-9
pubmed: 15870169
J Allergy Clin Immunol. 2011 Oct;128(4):864-871.e2
pubmed: 21636115
FASEB J. 2015 Apr;29(4):1395-403
pubmed: 25550456
Proc Soc Exp Biol Med. 1977 Apr;154(4):496-9
pubmed: 300878
J Interferon Res. 1988 Dec;8(6):705-16
pubmed: 3148005
Nat Microbiol. 2019 Dec;4(12):2064-2073
pubmed: 31477894
Blood. 2007 Apr 15;109(8):3139-46
pubmed: 17158224
Crit Rev Food Sci Nutr. 2019;59(1):72-88
pubmed: 28799778
Front Cell Infect Microbiol. 2018 Feb 06;8:13
pubmed: 29468141
Am J Gastroenterol. 2007 Feb;102(2):324-30
pubmed: 17100977
Neuroscience. 2016 Dec 17;339:463-477
pubmed: 27742460
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G207-16
pubmed: 12646422
Mol Aspects Med. 1983;6(2):101-97
pubmed: 6371429
J Clin Med. 2019 Nov 14;8(11):
pubmed: 31739460
Front Pharmacol. 2016 Mar 22;7:68
pubmed: 27047383
Front Immunol. 2020 Feb 11;11:186
pubmed: 32117308
Trans Am Clin Climatol Assoc. 2012;123:268-80; discussion 280
pubmed: 23303993
Inflamm Bowel Dis. 2014 Sep;20(9):1516-29
pubmed: 25072499
Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G9-19
pubmed: 21436313
Auton Neurosci. 2010 Feb 16;153(1-2):47-57
pubmed: 19729349
Histochem Cell Biol. 1999 Oct;112(4):257-63
pubmed: 10550609
Microb Pathog. 2017 May;106:171-181
pubmed: 26875998
Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G685-95
pubmed: 19095763
Cell. 2015 Apr 9;161(2):264-76
pubmed: 25860609
Gastroenterology. 2009 Dec;137(6):2074-83
pubmed: 19747920
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1943-8
pubmed: 18234854
ACS Chem Neurosci. 2013 Jan 16;4(1):48-63
pubmed: 23336044
J Intern Med. 1997 Nov;242(5):413-9
pubmed: 9408072
ISME J. 2016 Feb;10(2):460-77
pubmed: 26218241
Gastroenterology. 2007 Jan;132(1):397-414
pubmed: 17241888
BMB Rep. 2018 Apr;51(4):188-193
pubmed: 29335070
Nat Med. 2010 Jul;16(7):804-8
pubmed: 20581837
J Bone Miner Res. 2012 Jun;27(6):1357-67
pubmed: 22407806
Gastroenterology. 2009 Nov;137(5):1649-60
pubmed: 19706294
Aliment Pharmacol Ther. 2000 Jun;14(6):775-82
pubmed: 10848662
Front Immunol. 2019 Mar 11;10:277
pubmed: 30915065
Cell Immunol. 1995 Jun;163(1):1-9
pubmed: 7758118
Dig Dis Sci. 2015 Jan;60(1):101-8
pubmed: 25146842
Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L272-80
pubmed: 20495077
Gastroenterol Clin North Am. 2021 Sep;50(3):655-669
pubmed: 34304793
PLoS One. 2013 Oct 02;8(10):e75426
pubmed: 24098382
Gastroenterology. 2004 Jun;126(7):1657-64
pubmed: 15188158
J Immunol. 2013 Mar 1;190(5):2301-10
pubmed: 23355731
Front Biosci (Landmark Ed). 2019 Jan 1;24:514-526
pubmed: 30468670
Clin Gastroenterol Hepatol. 2005 Apr;3(4):349-57
pubmed: 15822040
J Allergy Clin Immunol. 2007 Feb;119(2):498-9
pubmed: 17291861
J Pharmacol Exp Ther. 2008 Apr;325(1):47-55
pubmed: 18192499
Hum Exp Toxicol. 2010 Apr;29(4):321-8
pubmed: 20154102
Ann Med. 1989 Feb;21(1):23-30
pubmed: 2538134
Drug Metab Dispos. 2009 Sep;37(9):1871-7
pubmed: 19487253
Biophys J. 1996 Oct;71(4):1952-60
pubmed: 8889169
Clin Exp Immunol. 2010 Jul 1;161(1):19-27
pubmed: 20408856
J Neuroinflammation. 2010 Jul 08;7:37
pubmed: 20615234
Gastroenterol Clin North Am. 2021 Sep;50(3):505-522
pubmed: 34304785
Pathogens. 2019 Aug 13;8(3):
pubmed: 31412603
Nature. 1989 Jun 29;339(6227):706-9
pubmed: 2472553