Enteric Nervous System in Neonatal Necrotizing Enterocolitis.
Necrotizing enterocolitis
enteric nervous system
gut dysbiosis
intestinal inflammation
neonates
premature
Journal
Current pediatric reviews
ISSN: 1875-6336
Titre abrégé: Curr Pediatr Rev
Pays: United Arab Emirates
ID NLM: 101240290
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
12
2020
revised:
26
02
2021
accepted:
08
06
2021
pubmed:
11
9
2021
medline:
18
3
2022
entrez:
10
9
2021
Statut:
ppublish
Résumé
The pathophysiology of necrotizing enterocolitis (NEC) is not clear, but increasing information suggests that the risk and severity of NEC may be influenced by abnormalities in the enteric nervous system (ENS). The purpose of this review was to scope and examine the research related to ENS-associated abnormalities that have either been identified in NEC or have been noted in other inflammatory bowel disorders (IBDs) with histopathological abnormalities similar to NEC. The aim was to summarize the research findings, identify research gaps in existing literature, and disseminate them to key knowledge end-users to collaborate and address the same in future studies. Articles that met the objectives of the study were identified through an extensive literature search in the databases PubMed, EMBASE, and Scopus. The sources identified through the literature search revealed that: (1) ENS may be involved in NEC development and post-NEC complications, (2) NEC development is associated with changes in the ENS, and (3) NEC-associated changes could be modulated by the ENS. The findings from this review identify the enteric nervous as a target in the development and progression of NEC. Thus, factors that can protect the ENS can potentially prevent and treat NEC and post-NEC complications. This review serves to summarize the existing literature and highlights a need for further research on the involvement of ENS in NEC.
Sections du résumé
BACKGROUND
BACKGROUND
The pathophysiology of necrotizing enterocolitis (NEC) is not clear, but increasing information suggests that the risk and severity of NEC may be influenced by abnormalities in the enteric nervous system (ENS).
OBJECTIVE
OBJECTIVE
The purpose of this review was to scope and examine the research related to ENS-associated abnormalities that have either been identified in NEC or have been noted in other inflammatory bowel disorders (IBDs) with histopathological abnormalities similar to NEC. The aim was to summarize the research findings, identify research gaps in existing literature, and disseminate them to key knowledge end-users to collaborate and address the same in future studies.
METHODS
METHODS
Articles that met the objectives of the study were identified through an extensive literature search in the databases PubMed, EMBASE, and Scopus.
RESULTS
RESULTS
The sources identified through the literature search revealed that: (1) ENS may be involved in NEC development and post-NEC complications, (2) NEC development is associated with changes in the ENS, and (3) NEC-associated changes could be modulated by the ENS.
CONCLUSION
CONCLUSIONS
The findings from this review identify the enteric nervous as a target in the development and progression of NEC. Thus, factors that can protect the ENS can potentially prevent and treat NEC and post-NEC complications. This review serves to summarize the existing literature and highlights a need for further research on the involvement of ENS in NEC.
Identifiants
pubmed: 34503418
pii: CPR-EPUB-117784
doi: 10.2174/1573396317666210908162745
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-24Subventions
Organisme : National Institutes of Health, NIH
ID : R01DK080684
Organisme : VA Research and Development Merit Review Award
ID : BX000136-08
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.